麻风病治愈患者结直肠癌及癌前病变的影响因素研究

doi:10.19485/j.cnki.issn2096-5087.2022.12.013

预防医学

2022, Vol. 34

Issue (12): 1257-1261 DOI: 10.19485/j.cnki.issn2096-5087.2022.12.013

疾病控制

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麻风病治愈患者结直肠癌及癌前病变的影响因素研究

张晓海, 施惠娟, 张洪涛, 钟华, 姚敏, 谭又吉

浙江省皮肤病防治研究所,浙江德清 313200

Factors affecting colorectal cancer and precancerous lesions among cured leprosy patients

ZHANG Xiaohai, SHI Huijuan, ZHANG Hongtao, ZHONG Hua, YAO Min, TAN Youji

Zhejiang Provincial Institute of Dermatology Prevention and Control, Deqing, Zhejiang 313200, China

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摘要目的分析麻风病治愈患者结直肠癌及癌前病变的影响因素,为麻风病治愈患者预防结直肠癌提供依据。方法于2019—2020年选择浙江省各麻风村（院）麻风病治愈患者为研究对象,通过问卷调查收集人口学信息、肠息肉家族史、肠息肉病史、吸烟、饮酒、饮食行为和近3年排便情况等资料;进行肛指检查、电子结肠镜检查和组织病理学检查,诊断结直肠癌及癌前病变;采用多因素logistic回归模型分析麻风病治愈患者结直肠癌及癌前病变的影响因素。结果调查麻风病治愈患者100例,男性72例,女性28例;年龄（67.23±3.42）岁;麻风残疾为0级13例,1级16例,2级71例。检出结直肠癌5例,检出率为5.00%;癌前病变26例,检出率为26.00%。多因素logistic回归分析结果显示,≥65岁（OR=7.128,95%CI：5.019~10.123）、残疾（OR=4.591,95%CI：2.942~7.163）、有肠息肉病史（OR=4.031,95%CI：3.052~5.325）、常吃霉变食物（OR=4.433,95%CI：2.920~6.729）、不常吃蔬菜（OR=4.411,95%CI：3.204~6.071）、血便（OR=4.341,95%CI：2.771~6.799）、黏液便（OR=4.577,95%CI：2.771~7.559）、有抑郁情绪（OR=3.935,95%CI：3.026~5.117）与麻风病治愈患者发生结直肠癌及癌前病变存在统计学关联。结论高龄、残疾、有肠息肉病史、常吃霉变食物、不常吃蔬菜、血便、黏液便、抑郁情绪可能增加麻风病治愈患者结直肠癌及癌前病变风险。

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	谭又吉

关键词 ：麻风病治愈患者, 结直肠癌, 癌前病变, 影响因素

Abstract：Objective To investigate the influencing factors of colorectal cancer and precancerous lesions among cured leprosy patients, so as to provide insights into prevention of colorectal cancer among cured leprosy patients. Methods All cured leprosy patients were recruited from each leprosy village (hospital) in Zhejiang Province from 2019 to 2020. Participants' demographic features, family and medical history of intestinal polyps, smoking, alcohol consumption, dietary behaviors and defecation during the recent three years were collected using questionnaire surveys. Colorectal cancer and precancerous lesions were diagnosed using rectal examination, electronic colonoscopy and histopathological examinations, and factors affecting the development of colorectal cancer and precancerous lesions were identified with a multivariable logistic regression model among cured leprosy patients. Results Totally 100 cured leprosy cases were enrolled, including 72 men and 28 women, and with a mean age of (67.23±3.42) years. There were 13 cases with grade 0 leprosy disability, 16 cases with grade 1 leprosy disability and 71 cases with grade 2 leprosy disability. The detection of colorectal cancer and precancerous lesions was 5.00% and 26.00%, respectively. Multivariable logistic regression analysis showed that age of 65 years and older (OR=7.128, 95%CI: 5.019-10.123), disability (OR=4.591, 95%CI: 2.942-7.163), a medical history of intestinal polyps (OR=4.031, 95%CI: 3.052-5.325), eating moldy food frequently (OR=4.433, 95%CI: 2.920-6.729), seldom eating vegetables (OR=4.411, 95%CI: 3.204-6.071), bloody stools (OR=4.341, 95%CI: 2.771-6.799), mucous stools (OR=4.577, 95%CI: 2.771-7.559) and presence of depression (OR=3.935, 95%CI: 3.026-5.117) were statistically associated with the development of colorectal cancer and precancerous lesions among cured leprosy patients. Conclusion Advanced age, disability, history of intestinal polyps, frequent intake of moldy food, infrequent consumption of vegetables, bloody stools, mucous stools, and depression may increase the risk of colorectal cancer and precancerous lesions among cured leprosy patients.

Key words： cured leprosy patient colorectal cancer precancerous lesion influencing factor

收稿日期: 2022-08-05 修回日期: 2022-11-04 出版日期: 2022-12-10

中图分类号:

R275.2

基金资助:浙江省医药卫生科学研究项目（2019KY367）

通信作者: 谭又吉,E-mail：38198834@qq.com

作者简介: 张晓海,本科,副主任医师,主要从事消化内科临床工作

引用本文:

张晓海, 施惠娟, 张洪涛, 钟华, 姚敏, 谭又吉. 麻风病治愈患者结直肠癌及癌前病变的影响因素研究[J]. 预防医学, 2022, 34(12): 1257-1261.
ZHANG Xiaohai, SHI Huijuan, ZHANG Hongtao, ZHONG Hua, YAO Min, TAN Youji. Factors affecting colorectal cancer and precancerous lesions among cured leprosy patients. Preventive Medicine, 2022, 34(12): 1257-1261.

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