Trend in incidence of colorectal cancer in Xiaoshan District from 2010 to 2024
LI Yurong, WANG Dongfei, GAO Yuanyuan, JIANG Yuanyuan, LIN Junying, XIAO Duanduan
Xiaoshan District Center for Disease Control and Prevention (Xiaoshan District Institute of Public Health Supervision), Hangzhou, Zhejiang 311203, China
Abstract：Objective To analyze the incidence trend of colorectal cancer in Xiaoshan District, Hangzhou City from 2010 to 2024, and predict the incidence of colorectal cancer from 2025 to 2027, so as to provide the evidence for improving the prevention and control strategies of colorectal cancer. Methods Colorectal cancer incidence data from 2010 to 2024 in Xiaoshan District were collected through the Hangzhou Municipal Chronic Disease Monitoring Management System. The crude incidence of colorectal cancer was calculated, and standardized using the data from the Sixth National Population Census in 2010 (Chinese standardized rate) and the Segi's world standard population (world standardized rate). The trend of colorectal cancer incidence from 2010 to 2024 was analyzed using the average annual percent change (AAPC). An exponential smoothing state space model with trigonometric seasonality, box-cox transformation, ARMA errors, trend and seasonal components (TBATS) was established to forecast the crude incidence of colorectal cancer from 2025 to 2027. Results There were 10 726 new cases of colorectal cancer in Xiaoshan District from 2010 to 2024. The crude incidence, Chinese standardized rate, and world standardized rate of colorectal cancer were 59.25/105, 38.62/105 and 29.50/105, respectively. The crude incidence, Chinese standardized rate, and world standardized rate of colorectal cancer in males were 70.56/105, 44.44/105 and 35.58/105, respectively, while those in females were 48.37/105, 32.69/105 and 23.70/105, respectively. The Chinese standardized rate of colorectal cancer was significantly higher in males than in females (P<0.05). The crude incidence of colorectal cancer in males, females and the whole population showed upward trends from 2010 to 2024 (AAPC=4.916%, 3.795% and 4.442%, all P<0.05). The crude incidence of colorectal cancer in the groups of 0-<35, 35-<50, 50-<75 and ≥75 years were 1.75/105, 19.86/105, 112.28/105 and 272.99/105, respectively, showing an increasing trend with age (P<0.05). From 2010 to 2024, the crude incidence of colorectal cancer in the ≥75 years group showed an increasing trend (AAPC=4.470%, P<0.05), while no significant trend was observed in other age groups (all P>0.05). TBATS model demonstrated good fitting (predictive) performance, indicating a year-by-year increase in the crude incidence of colorectal cancer across the whole population from 2025 to 2027, with an estimated rate reaching 70.45/105 in 2027. Conclusions The crude incidence of colorectal cancer in Xiaoshan District showed an increasing trend from 2010 to 2024, and it is predicted to continue to increase from 2025 to 2027. Males and the elderly are the key populations for colorectal cancer prevention and control.
李玉荣, 王冬飞, 高媛媛, 蒋园园, 林君英, 肖段段. 2010—2024年萧山区结直肠癌发病趋势分析[J]. 预防医学, 2025, 37(9): 927-931,936.
LI Yurong, WANG Dongfei, GAO Yuanyuan, JIANG Yuanyuan, LIN Junying, XIAO Duanduan. Trend in incidence of colorectal cancer in Xiaoshan District from 2010 to 2024. Preventive Medicine, 2025, 37(9): 927-931,936.
[1] BRAY F,LAVERSANNE M,SUNG H,et al.Global cancer statistics 2022:GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries[J].CA Cancer J Clin,2024,74(3):229-263. [2] 赫捷,魏文强.2019中国肿瘤登记年报[M].北京:人民卫生出版社,2021. HE J,WEI W Q.2019 China cancer registry annual report[M].Beijing:People's Medical Publishing House,2021.(in Chinese) [3] HAN B F,ZHENG R S,ZENG H M,et al.Cancer incidence and mortality in China,2022[J].J Natl Cancer Cent,2024,4(1):47-53. [4] 朱陈,龚巍巍,钟节鸣,等.浙江省重点人群结直肠癌筛查项目设计和实施方案[J].中国肿瘤,2020,29(12):899-903. ZHU C,GONG W W,ZHONG J M,et al.Zhejiang Colorectal Cancer Screening Program:overview and study design[J].China Cancer,2020,29(12):899-903.(in Chinese) [5] 程向东,杜灵彬.2023浙江省肿瘤登记年报[M].北京:清华大学出版社,2024. CHENG X D,DU L B.Zhejiang cancer registry annual report[M].Beijing:Tsinghua University Press,2024.(in Chinese) [6] 李玉荣,汪芬娟,王冬飞,等.2015—2020年萧山区恶性肿瘤发病趋势分析[J].预防医学,2023,35(8):687-691. LI Y R,WANG F J,WANG D F,et al.Trends in incidence of malignant tumors in Xiaoshan District from 2015 to 2020[J].China Prev Med J,2023,35(8):687-691.(in Chinese) [7] DE LIVERA A M,HYNDMAN R J,SNYDER R D.Forecasting time series with complex seasonal patterns using exponential smoothing[J].J Am Stat Assoc,2011,106(496):1513-1527. [8] 寻鲁宁,王冲,沈成凤,等.1990—2019年中国结直肠癌发病趋势分析及预测模型比较[J].中国肿瘤,2023,32(4):279-286. XUN L N,WANG C,SHEN C F,et al.Prediction of colorectal cancer incidence in China with three different models based on trends from 1990 to 2019[J].China Cancer,2023,32(4):279-286.(in Chinese) [9] 胡碧波,傅克本,邵哲.2015—2021年浙江省余姚市结直肠癌发病死亡情况及生存分析[J].疾病监测,2022,37(9):1230-1235. HU B B,FU K B,SHAO Z,et al.Morbidity,mortality and survival of colorectal cancer in Yuyao,Zhejiang,2015-2021[J].Dis Surveill,2022,37(9):1230-1235.(in Chinese) [10] ZHOU J C,ZHENG R S,ZHANG S W,et al.Colorectal cancer burden and trends:comparison between China and major burden countries in the world[J].Chin J Cancer Res,2021,33(1):1-10. [11] 夏昌发,陈万青.中国恶性肿瘤负担归因于人口老龄化的比例及趋势分析[J].中华肿瘤杂志,2022,44(1):79-85. XIA C F,CHEN W Q.Fractions and trends of cancer burden attributable to population ageing in China[J].Chin J Oncol,2022,44(1):79-85.(in Chinese) [12] 毛纯,陈桂芳,盘宇洁,等.1972—2015年广州市城区居民结直肠癌发病率和死亡率趋势分析及预测[J].中华预防医学杂志,2021,55(5):640-645. MAO C,CHEN G F,PAN Y J,et al.Trend analysis and prediction of colorectal cancer morbidity and mortality of residents in urban areas of Guangzhou from 1972 to 2015[J].Chin J Prev Med,2021,55(5):640-645.(in Chinese) [13] 赵琳,蒋龙艳,徐斌,等.南宁市五种主要恶性肿瘤发病率分析[J].预防医学,2025,37(2):135-138. ZHAO L,JIANG L Y,XU B,et al.Incidence characteristics of five major malignant tumors in Nanning City[J].China Prev Med J,2025,37(2):135-138.(in Chinese) [14] 陈单,王亚伟,黄芳,等.2003—2019年上海市嘉定区结直肠癌流行趋势研究[J].中国全科医学,2024,27(10):1261-1266. CHEN D,WANG Y W,HUANG F,et al.Epidemic trend analysis of colorectal cancer in Jiading District,Shanghai from 2003 to 2019[J].Chin Gen Pract,2024,27(10):1261-1266.(in Chinese) [15] ARNOLD M,SIERRA M S,LAVERSANNE M,et al.Global patterns and trends in colorectal cancer incidence and mortality[J].Gut,2017,66(4):683-691. [16] WONG M C S,HUANG J J,LOK V,et al.Differences in incidence and mortality trends of colorectal cancer worldwide based on sex,age,and anatomic location[J].Clin Gastroenterol Hepatol,2021,19(5):955-966. [17] KIM M H,PARK S,YI N Y,et al.Colorectal cancer mortality trends in the era of cancer survivorship in Korea:2000-2020[J].Ann Coloproctol,2022,38(5):343-352. [18] 陈淑淑,龚巍巍,关云琦,等.1990—2019年浙江省结直肠癌疾病负担和危险因素分析[J].预防医学,2024,36(3):203-206. CHEN S S,GONG W W,GUAN Y Q,et al.Disease burden and risk factors of colorectal cancer in Zhejiang Province from 1990 to 2019[J].China Prev Med J,2024,36(3):203-206.(in Chinese) [19] 叶中文,潘少媚,陈国荣,等.2017—2019年珠海市恶性肿瘤发病及死亡情况分析[J].实用癌症杂志,2025,40(4):686-690. YE Z W,PAN S M,CHEN G R,et al.Characteristic analysis of malignant tumor incidence and death in Zhuhai,2017-2019[J].Pract J Cancer,2025,40(4):686-690.(in Chinese)
