Trend in incidence and change in age at onset of lung cancer in Wujiang District from 2012 to 2021
ZHANG Rongyan1, GU Siyi1, YANG Mei1, SHEN Jianxin1, CUI Junpeng2, LU Yan2
1. Wujiang District Center for Disease Control and Prevention, Suzhou, Jiangsu 215200, China; 2. Suzhou Center for Disease Control and Prevention, Suzhou, Jiangsu 215000, China
Abstract：Objective To investigate the trend in incidence and change in age at onset of lung cancer in in Wujiang District, Suzhou City, Jiangsu Province from 2012 to 2021, so as to provide a basis for strengthening targeted prevention and control of lung cancer. Methods Data of lung cancer incidence from 2012 to 2021 were collected through the Wujiang District Tumor Follow-up Registration Information System. The crude incidence, truncated incidence for 35 to 64 years, and cumulative incidence for 0 to 74 years were calculated. Chinese population-standardized incidence, Chinese population-standardized average age at onset, and Chinese population-standardized incidence proportion were calculated using the age structure of the standard population from the Fifth National Population Census in 2000. The trend in incidence of lung cancer from 2012 to 2021 was evaluated using average annual percent change (AAPC). The trend in the Chinese population-standardized average age at onset of lung cancer from 2012 to 2021 was evaluated using a linear regression model. Results From 2012 to 2021, the crude incidence, the Chinese population-standardized incidence and truncated incidence for 35 to 64 years of lung cancer in Wujiang District were 84.57/105, 37.28/105 and 52.10/105, respectively, all showing upward trends (AAPC=2.489%, 2.034% and 4.654%, all P<0.05). The cumulative incidence for 0 to 74 years was 4.48%, showing no significant trend (P>0.05). The Chinese population-standardized incidence was higher in males than in females (48.16/105 vs. 26.81/105). The Chinese population-standardized incidence of lung cancer in females showed an upward trend (AAPC=8.174%, P<0.05), while the trend in males was not statistically significant (P>0.05). The crude incidence of lung cancer showed upward trends in the total population and females aged 0-<45 years (AAPC=18.287% and 25.343%, both P<0.05) and those aged 45-<55 age group (AAPC=8.003% and 17.629%, both P<0.05). The Chinese population-standardized average age at onset of lung cancer in total population and females decreased from 67.58 and 65.48 years in 2012 to 60.15 and 54.88 years in 2021, with an average annual reduction of 0.611 and 0.964 years, respectively (both P<0.05). The Chinese population-standardized incidence proportion showed upward trends for the total population and females under 65 years (AAPC=3.879% and 4.639%, both P<0.05). No statistically significant trends were observed in the Chinese population-standardized average age at onset or incidence proportion in males (both P>0.05). Conclusions From 2012 to 2021, the incidence of lung cancer in Wujiang District showed an increasing trend and a trend toward younger onset age. Young and middle-aged females had emerged as a key target population for lung cancer prevention and control.
张荣艳, 顾思义, 杨梅, 沈建新, 崔俊鹏, 陆艳. 2012—2021年吴江区肺癌发病趋势及年龄变化分析[J]. 预防医学, 2025, 37(10): 1029-1034.
ZHANG Rongyan, GU Siyi, YANG Mei, SHEN Jianxin, CUI Junpeng, LU Yan. Trend in incidence and change in age at onset of lung cancer in Wujiang District from 2012 to 2021. Preventive Medicine, 2025, 37(10): 1029-1034.
[1] 韩仁强,缪伟刚,俞浩,等.2020年江苏省恶性肿瘤发病和死亡现状分析[J].江苏预防医学,2024,35(5):568-574. HAN R Q,MIAO W G,YU H,et al.Incidence and mortality analysis of cancers in Jiangsu Province in 2020[J].Jiangsu J Prev Med,2024,35(5):568-574.(in Chinese) [2] 鲁斌元,丁冠江,胡守财,等.1990—2021年中国呼吸道恶性肿瘤的疾病负担及变化趋势分析[J/OL].中国胸心血管外科临床杂志,2025[2025-09-19].https://link.cnki.net/urlid/51.1492.r.20250409.1359.024. LU B Y,DING G J,HU S C,et al.Disease burden and changing trend of respiratory tract malignancies from1990 to 2021 in China[J/OL].Chin J Clin Thorac Cardiovasc Surg,2025[2025-09-19].https://link.cnki.net/urlid/51.1492.r.20250409.1359.024.(in Chinese) [3] 郑荣寿,陈万青.癌症发病年龄变化分析[J].中华预防医学杂志,2018,52(6):673-674. ZHENG R S,CHEN W Q.An introduction to the analysis of the age changes for cancer incidence[J].Chin J Prev Med,2018,52(6):673-674.(in Chinese) [4] 赫捷,魏文强.2022中国肿瘤登记年报[M].北京:人民卫生出版社,2025. HE J,WEI W Q.China cancer registry annual report 2022[M].Beijing:People's Medical Publishing House,2025.(in Chinese) [5] 朱宝立,周金意,韩仁强.江苏省恶性肿瘤报告(2022)[M].南京:东南大学出版社,2024. ZHU B L,ZHOU J Y,HAN R Q.Jiangsu cancer report(2022)[M].Nanjing:Southeast University Press,2024.(in Chinese) [6] 江雨琛,俞浩,罗鹏飞,等.1990—2019年江苏省肺癌疾病负担及其危险因素变化趋势研究[J].中国肿瘤,2022,31(5):327-334. JIANG Y C,YU H,LUO P F,et al.Trends of burden on lung cancer and related risk factors in Jiangsu Province from 1990 to 2019[J].China Cancer,2022,31(5):327-334.(in Chinese) [7] 李金,黄文,陈奇峰.2014—2019年绍兴市肺癌发病趋势分析[J].预防医学,2021,33(9):889-892. LI J,HUANG W,CHEN Q F.Trend of lung cancer incidence in Shaoxing City from 2014 to 2019[J].China Prev Med J,2021,33(9):889-892.(in Chinese) [8] 项彩英,汪德兵.2011—2022年开化县肺癌发病和死亡趋势分析[J].预防医学,2023,35(10):885-889. XIANG C Y,WANG D B.Trends in incidence and mortality of lung cancer in Kaihua County from 2011 to 2022[J].China Prev Med J,2023,35(10):885-889.(in Chinese) [9] HILL W,LIM E L,WEEDEN C E,et al.Lung adenocarcinoma promotion by air pollutants[J].Nature,2023,616(7955):159-167. [10] 夏昌发,陈万青.中国恶性肿瘤负担归因于人口老龄化的比例及趋势分析[J].中华肿瘤杂志,2022,44(1):79-85. XIA C F,CHEN W Q.Fractions and trends of cancer burden attributable to population ageing in China[J].Chin J Oncol,2022,44(1):79-85.(in Chinese) [11] 白勇,李萍,姜楠.肥胖、外周血血脂指标与非小细胞肺癌的孟德尔随机化研究[J].预防医学,2024,36(6):518-522. BAI Y,LI P,JIANG N.Associations of obesity and peripheral blood lipid indicators with non-small cell lung cancer:a Mendelian randomization study[J].China Prev Med J,2024,36(6):518-522.(in Chinese) [12] 谢栋臣,张莉,何纳,等.上海浦东新区九种筛检癌症发病率与死亡率变化模式及过度诊断分析[J].中华肿瘤防治杂志,2025,32(10):599-607. XIE D C,ZHANG L,HE N,et al.Changing patterns and potential overdiagnosis of major screened cancers in Pudong New Area of Shanghai[J].Chin J Cancer Prev Treat,2025,32(10):599-607.(in Chinese) [13] 徐仙会,陈杨,朱云芳,等.2020年云南省肿瘤登记地区肺癌发病和死亡情况及2012—2020年趋势分析[J].实用肿瘤学杂志,2024,38(6):367-371. XU X H,CHEN Y,ZHU Y F,et al.Incidence and mortality of lung cancer in cancer registration areas of Yunnan Province in 2020 and the trends from 2012 to 2020[J].Pract Oncol J,2024,38(6):367-371.(in Chinese) [14] 丁贤彬,吕晓燕,焦艳,等.2019年重庆市30岁及以上人群归因于被动吸烟的肺癌疾病负担研究[J].实用预防医学,2022,29(8):911-915. DING X B,LYU X Y,JIAO Y,et al.Disease burden of lung cancer attributable to passive smoking among population aged 30 years and above in Chongqing Municipality,2019[J].Pract Prev Med,2022,29(8):911-915.(in Chinese) [15] 孙鑫,覃文进,刘理礼,等.肺癌发病危险因素最新研究进展[J].现代肿瘤医学,2022,30(4):753-756. SUN X,QIN W J,LIU L L,et al.Recent advances of research on risk factors of lung cancer[J].J Mod Oncol,2022,30(4):753-756.(in Chinese) [16] 梁敏,吴宁.女性肺癌的危险因素和筛查现状[J].国际医学放射学杂志,2022,45(5):539-544. LIANG M,WU N.Risk factors and screening of lung cancer in women[J].Int J Med Radiol,2022,45(5):539-544.(in Chinese) [17] 何杰,李静,尹昕然,等.1990—2021年中国肺癌发病趋势及未来预测分析[J].实用心脑肺血管病杂志,2025,33(8):1-5. HE J,LI J,YIN X R,et al.Incidence trend and future prediction of lung cancer in China from 1990 to 2021[J].Pract J Card Cereb Pneumal Vasc Dis,2025,33(8):1-5.(in Chinese) [18] 倪雪,许宁,王强.基于贝叶斯时空模型探究中国女性肺癌发病风险及其影响因素[J].环境卫生学杂志,2022,12(6):407-414. NI X,XU N,WANG Q.Analysis on the incidence risk and their influence factors of female lung cancer in China based on Bayesian spatio-temporal model[J].J Environ Hyg,2022,12(6):407-414.(in Chinese)
