Abstract:Objective To investigate the influencing factors for delay in healthcare-seeking, definitive diagnosis and identification in patients with pulmonary tuberculosis (PTB) in Minhang District, Shanghai Municipality, so as to provide the basis for effectively reducing delay in PTB patients. Methods Data of PTB patients in Minhang District from 2017 to 2022 were collected from the Infectious Disease Reporting Information System of Chinese Disease Prevention and Control Information System. The prevalence rates of delay in healthcare-seeking, definitive diagnosis and identification were analyzed, and factors affecting delay in healthcare-seeking, definitive diagnosis and identification were identified using multivariable logistic regression models. Results A total of 4 214 PTB patients were reported in Minhang District from 2017 to 2022, including 2 802 males and 1 412 females, with a male-to-female ratio of 1.98∶1. The majority of patients were aged 25 to <45 years (1 664 cases, 39.49%). The prevalence rates of delay in healthcare-seeking, definitive diagnosis and identification were 36.81%, 30.21% and 38.09%, respectively. Delay in healthcare-seeking was associated with the year (2018, OR=0.708; 2019, OR=0.549; 2020, OR=0.670; 2021, OR=0.682), gender (female, OR=1.199), occupation (worker, OR=1.379; housekeeping service/housework/unemployed, OR=1.481), case identification route (symptom-based consultation, OR=11.159), and level of the first-diagnosed hospital (city-level, OR=1.528). Delay in definitive diagnosis was associated with age (45 to <65 years, OR=1.476), occupation (commercial service, OR=0.687; housekeeping service/housework/unemployed, OR=0.672), household registration (non-local, OR=0.820), case identification route (symptom-based consultation, OR=0.616), pathogen test result (negative/not tested, OR=1.903), and the level of the first-diagnosed hospital (city-level, OR=0.311). Delay in identification was associated with the year (2018, OR=0.785; 2019, OR=0.647; 2020, OR=0.790; 2021, OR=0.710), occupation (commercial service, OR=0.687), household registration (non-local, OR=0.848) and level of the first-diagnosed hospital (city-level, OR=0.560). Conclusions Year, gender, occupation, case identification route and level of the first-diagnosed hospital are influencing factors for delay in healthcare-seeking in PTB patients. Age, occupation, household registration, case identification route, pathogen test result and level of the first-diagnosed hospital are influencing factors for delay in definitive diagnosis. Year, occupation, household registration and level of the first-diagnosed hospital are influencing factors for delay in identification.
[1] World Health Organization.Global tuberculosis report 2023[R].Geneva:WHO,2023. [2] 王微. 基于结核病的流行趋势与防控[J].世界最新医学信息文摘,2019,19(70):215-238. WANG W.Epidemic trend and prevention and control of tuberculosis based on tuberculosis[J].World Latest Med Inf(Electron Version),2019,19(70):215-238.(in Chinese) [3] 全国第五次结核病流行病学抽样调查技术指导组,全国第五次结核病流行病学抽样调查办公室.2010年全国第五次结核病流行病学抽样调查报告[J].中国防痨杂志,2012,34(8):485-508. Technical Guidance Group of the Fifth National TB Epidemiological Survey,The Office of the Fifth National TB Epidemiological Survey.The fifth national tuberculosis epidemiological survey in 2010[J].Chin J Antituberc,2012,34(8):485-508.(in Chinese) [4] 傅丽娟,汪业胜,朱文龙,等.湖州市2008—2018年肺结核患者就诊延迟情况及影响因素[J].中华疾病控制杂志,2021,25(2):235-239. FU L J,WANG Y S,ZHU W L,et al.Consultation delay and influencing factors among pulmonary tuberculosis patients in Huzhou City from 2008 to 2018[J].Chin J Dis Control Prev,2021,25(2):235-239.(in Chinese) [5] 赵承杰,何雪姣.136例初治肺结核患者就诊延迟的影响因素分析[J].预防医学,2017,29(12):1235-1237. ZHAO C J,HE X J.Influencing factors of patient delay among 136 cases of newly diagnosed pulmonary tuberculosis patients[J].China Prev Med J,2017,29(12):1235-1237.(in Chinese) [6] 中华人民共和国卫生部结核病控制项目办公室.世界银行贷款中国结核病控制项目工作手册2版[M].北京:中华人民共和国卫生部结核病控制项目办公室,1995. Tuberculosis Control Project Office of the Ministry of Health of the People's Republic of China.Manual for the World Bank Loan China Tuberculosis Control Project(2nd ed)[M].Beijing:Tuberculosis Control Project Office of the Ministry of Health of the People's Republic of China,1995.(in Chinese) [7] 宋媛媛,李涛,夏辉,等.1997—2023年全国肺结核报告发病流行病学特征[J].中国防痨杂志,2024,46(10):1198-1208. SONG Y Y,LI T,XIA H,et al.Analysis of the epidemiological characteristics of national reported pulmonary tuberculosis incidence,1997-2023[J].Chin J Antituberc,2024,46(10):1198-1208.(in Chinese) [8] 杨超,王晶,唐桂林.2012—2021年北京市通州区流动人口肺结核患者就诊延迟的变化趋势及影响因素分析[J].疾病监测,2023,38(9):1033-1038. YANG C,WANG J,TANG G L.Analysis on trend of medical care seeking delay in pulmonary tuberculosis patients in floating population and influencing factors in Tongzhou District of Beijing,2012-2021[J].Dis Surveill,2023,38(9):1033-1038.(in Chinese) [9] 刘旷怡,徐巧,葛木村,等.2008—2021年咸宁市肺结核病患者就诊延迟及影响因素分析[J].公共卫生与预防医学,2023,34(3):74-78. LIU K Y,XU Q,GE M C,et al.Treatment delay and influencing factors of tuberculosis patients in Xianning from 2008 to 2021[J].J Pub Health Prev Med,2023,34(3):74-78.(in Chinese) [10] 周芳静,冯慧莹,方兰君,等.2016—2020年广东省活动性肺结核患者发现延迟的变化趋势及影响因素分析[J].中国防痨杂志,2023,45(1):85-95. ZHOU F J,FENG H Y,FANG L J,et al.Analysis on the trend and influencing factors of detection delay in patients with active tuberculosis in Guangdong Province from 2016 to 2020[J].Chin J Antituberc,2023,45(1):85-95.(in Chinese) [11] 刘健雄,杜雨华,沈鸿程,等.2008—2018年广州市结核病患者诊断延误影响因素分析[J].中国防痨杂志,2021,43(1):80-86. LIU J X,DU Y H,SHEN H C,et al.Influencing factors of pulmonary tuberculosis diagnosis delay in Guangzhou,2008-2018[J].Chin J Antituberc,2021,43(1):80-86.(in Chinese) [12] 李德洋,苏德奇,张为胜,等.乌鲁木齐市肺结核患者就诊、确诊、发现延迟的影响因素分析[J].预防医学,2020,32(11):1150-1154. LI D Y,SU D Q,ZHANG W S,et al.Influencing factors of pulmonary tuberculosis patient,diagnosis,and detection delay in Urumqi City[J].China Prev Med J,2020,32(11):1150-1154.(in Chinese) [13] CHEN X,DU L,WU R H,et al.Tuberculosis-related stigma and its determinants in Dalian,Northeast China:a cross-sectional study[J/OL].BMC Public Health,2021,21(1)[2024-11-12].https://doi.org/10.1186/s12889-020-10055-2. [14] WONDAWEK T M,ALI M M.Delay in treatment seeking and associated factors among suspected pulmonary tuberculosis patients in public health facilities of Adama town,Eastern Ethiopia[J/OL].BMC Public Health,2019,19(1)[2024-11-12].https://doi.org/10.1186/s12889-019-7886-7. [15] ANIMUT Y,GODNO A B,NIGATU S G,et al.Delay in seeking treatment and associated factors among pulmonary tuberculosis patients attending public health facilities in the Metekel Zone,Benishangul Gumuz Region,Western Ethiopia[J/OL].Front Public Health,2024,12[2024-11-12].https://doi.org/10.3389/fpubh.2024.1356770. [16] BATBAYAR B,KARIYA T,BOLDOO T,et al.Patient delay and health system delay of patients with newly diagnosed pulmonary tuberculosis in Mongolia,2016-2017[J].Nagoya J Med Sci,2022,84(2):339-351.