[1] CARAMORI G, CASOLARI P, GIUFFRE S, et al. COPD pathology in the small airways[J].Panminerva Med, 2011, 53(1):51-70. [2] CRISAFULLI E,MENENDEZ R,HUERTA A,et al.Systemic inflammatory pattern of patients with community-acquired pneumonia with and without COPD[J].Chest,2013,143(4):1009-1017. [3] BARNES P J. Reduced histone deacetylase in COPD:clinical implications[J]. Chest, 2006, 129(1): 151-155. [4] 中华医学会呼吸病学分会慢性阻塞性肺疾病学组. 慢性阻塞性肺疾病诊治指南(2013年修订版)[J]. 中华结核和呼吸杂志,2013,36(4): 255-264. [5] 慢性阻塞性肺疾病急性加重诊治专家组. 慢性阻塞性肺疾病急性加重(AECOPD)诊治中国专家共识(2014年修订版)[J]. 国际呼吸杂志, 2014, 34(1): 1-11. [6] 田春燕,张继红,李伟国,等.细胞因子与COPD炎症机制研究进展[J].临床肺科杂志,2011,16(2):248-249. [7] FOGARTY A W, BRITTON J R, JONES S, et al. Systemic inflammation and decline in lung function in a general population: a prospective study[J]. Thorax, 2007, 62( 6) : 515- 520. [8] SIN D D, MAN S F. Systemic inflammation and mortality in chronic obstructive pulmonary disease[J]. Can J Physiol Pharmacol, 2007, 85(1) : 141- 147. [9] ITO K,ITO M,ELLIOTT W M,et al. Decreased histone deacetylase activity in chronic obstructive pulmonary disease[J]. N Engl J Med,2005,352(19):1967-1976. [10] HOGG J C,CHU F,UTOKAPARCH S,et al. The nature of small airway obstruction in chronic obstructive pulmonary disease[J].New Engl J Med,2004,350(2):2645-2653. [11] BARNES P J. Histone deacetylase-2 and airway disease[J]. Ther Adv Respir Dis, 2009, 3(5):235-243. [12] 叶瑞海,张鸣华,慈晓,等.慢性阻塞性肺疾病急性加重期患者外周血组蛋白去乙酰化酶2的表达及临床意义[J]. 浙江医学,2013,35(10): 911-913. [13] TOMITA K, BARNES P J, ADOCICK I M.The effect of oxidative stress on histone acetylation and IL-8 release[J]. Biochem Biophys Res Commun, 2003,301(2):572-577. [14] MOODIE F M, MARWICK J A, ANDERSON C S, et al.Oxidatives tress and cigarette smoke alter chromatin remodeling but differentially regulate NF-kappaB activation and proinflammatory cytokine release in alveolar epithelial cells[J].FASEB J, 2004,18(12):1897-1899. [15] ITO M,YAMADA K, VITALIS T Z,et al.Latent adenovirus infection decreases histone deadetylase activity in the lungs of ovalbumin sensitized guinea pigs[J].Am J Respir Crit Care Med, 2004, 169(7):A78.