Comparison of the value of a body shape index and body roundness index in predicting non-alcoholic fatty liver disease among non-obese population
WU Zijing1,2, LI Jixin2, QIU Linjie2, REN Yan2, LI Meijie2, ZOU Chacha1,2, ZHANG Jin2
1. Graduate School of Beijing University of Chinese Medicine, Beijing 100029, China; 2. Xiyuan Hospital of China Academy of Chinese Medical Sciences, Beijing 100091, China
Abstract：Objective To compare the value of a body shape index (ABSI) and body roundness index (BRI) in predicting non-alcoholic fatty liver disease (NAFLD) among non-obese population, so as to provide a reference for the early identification of populations at high risk of NAFLD. Methods Adults with a body mass index (BMI) of less than 28 kg/m2 who underwent health check-ups in Xiyuan Hospital of China Academy of Chinese Medical Sciences from 2022 to 2024 were selected as the study subjects. Demographic information, disease history, height, weight, waist circumference, blood pressure, and blood lipid indicators were collected, and ABSI and BRI were calculated. NAFLD was diagnosed using abdominal ultrasound. A multivariable logistic regression model was employed to analyze the relationships between ABSI, BRI and NAFLD among non-obese population. A generalized additive model combined with the penalized spline method was used to fit smooth curves to identify nonlinear relationships, and threshold effects were utilized to determine inflection points. The values of ABSI and BRI in predicting NAFLD among non-obese population were used the receiver operating characteristic (ROC) curve. Results A total of 1 195 individuals were surveyed, including 345 males (28.87%) and 850 females (71.13%). A total of 348 cases of NAFLD were detected among the non-obese population, with a detection rate of 29.12%. The adjusted ABSI (sABSI) in the NAFLD group and non-NAFLD group were 7.95±0.33 and 8.08±0.34, while the BRI were 3.35±0.79 and 4.15±0.64, respectively, with statistically significant differences between the two groups (both P<0.05). Multivariable logistic regression analysis showed that, after adjusting for demographic information, disease history, blood pressure, and blood lipid indicators, both sABSI (OR=1.932, 95%CI: 1.184-3.158) and BRI (OR=1.594, 95%CI: 1.071-2.360) were significantly associated with NAFLD among non-obese population. Nonlinear positive correlations were observed between sABSI, BRI, and NAFLD among non-obese population. When sABSI≤8.46 and BRI≥2.72, both indices were positively associated with NAFLD. The area under the ROC curve for ABSI and BRI in predicting NAFLD risk among non-obese population were 0.619 and 0.782, respectively, with optimal cut-off values of 0.082 and 3.656, respectively. Conclusions ABSI and BRI show a non-linear relationship with NAFLD among non-obese population. BRI demonstrates relatively better performance in predicting NAFLD risk among this population and can serve as an auxiliary indicator for the early identification of NAFLD among non-obese population.
吴梓敬, 李纪新, 邱林杰, 任燕, 李美洁, 邹姹姹, 张晋. 身体形态指数和身体圆度指数预测非肥胖人群非酒精性脂肪性肝病的效果比较[J]. 预防医学, 2025, 37(12): 1222-1227.
WU Zijing, LI Jixin, QIU Linjie, REN Yan, LI Meijie, ZOU Chacha, ZHANG Jin. Comparison of the value of a body shape index and body roundness index in predicting non-alcoholic fatty liver disease among non-obese population. Preventive Medicine, 2025, 37(12): 1222-1227.
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