Abstract：Objective To investigate the vitamin D levels in children aged 1 year in Shaoxing City, Zhejiang Province, so as to provide the basis for prevention and treatment of vitamin D deficiency in children and promoting their health. Methods The 1-year-old children who underwent health examinations at the Department of Child Health Care of Shaoxing Maternal and Child Health Care Hospital from September 2023 to August 2024 were selected. Basic information of the children was collected through the medical record information system, and their length and weight were measured. The length, weight and nutritional status were evaluated according to the Technical Specifications for the Management of Nutritional Diseases in Children. Serum 25-hydroxyvitamin D [25- (OH) D] levels were measured using electrochemiluminescence assay, and vitamin D levels were assessed based on the fifth edition of Child Health Care. The vitamin D levels were analyzed among the children with different genders, testing months, and growth status. Results A total of 2 245 children were recruited, including 1 189 boys (52.96%) and 1 056 girls (47.04%). The median serum 25- (OH) D level was 39.98 (interquartile range, 16.63) ng/mL. Vitamin D insufficiency was observed in 279 children, with an insufficiency rate of 12.43%. The median serum 25- (OH) D level in boys was 39.26 (interquartile range, 17.75) ng/mL, which was lower than that in girls at 41.39 (17.75) ng/mL (P<0.05). The vitamin D insufficiency rate was 13.04% in boys and 11.74% in girls, with no statistically significant difference (P>0.05). The lowest vitamin D insufficiency rate was observed in August at 4.95%, while the highest rate was in September at 23.89%, showing the statistically significant difference across testing months (P<0.05). The children with above-average length ratings, higher weight ratings and obesity had higher vitamin D insufficiency rates, at 17.29%, 20.86% and 20.88%, respectively. The vitamin D insufficiency rate increased with higher weight and nutritional status ratings (both P<0.05), but no significant change was observed with higher length ratings (P>0.05). Conclusions The vitamin D insufficiency rate among 1-year-old children in Shaoxing City was 12.43%, with variations observed in different testing months, weight and nutritional status. Targeted prevention and intervention measures should be implemented to address these differences.
余红, 刘丹, 章逸莉, 陈晓霞. 绍兴市1岁儿童维生素D水平分析[J]. 预防医学, 2025, 37(4): 417-420.
YU Hong, LIU Dan, ZHANG Yili, CHEN Xiaoxia. Analysis of vitamin D levels among 1-year-old children in Shaoxing City. Preventive Medicine, 2025, 37(4): 417-420.
[1] GOMES F,BLACK R E,SMITH E,et al.Micronutrient supplements in pregnancy:an urgent priority[J].Lancet Glob Health,2022,10(9):1-12. [2] 安娜,赵宜乐,张古英,等.2010—2020年中国健康儿童维生素D水平的Meta分析[J].中国儿童保健杂志,2021,29(10):1109-1114. AN N,ZHAO Y L,ZHANG G Y,et al.Meta-analysis of vitamin D level in healthy Chinese children over the past 10 years[J].Chin J Child Health Care,2021,29(10):1109-1114.(in Chinese) [3] ZHOU A,SELVANAYAGAM J B,HYPPÖNEN E,et al.Non-linear mendelian randomization analyses support a role for vitamin D deficiency in cardiovascular disease risk[J].Eur Heart J,2022,43(18):1731-1739. [4] STOICA A B,MARGINEAN C.The impact of vitamin D deficiency on infants' health[J].Nutrients,2023,15(20):1-15. [5] 赵艳,秦锐,马向华.江苏省0~5岁儿童维生素D营养状况研究[J].中国儿童保健杂志,2020,28(11):1214-1218. ZHAO Y,QIN R,MA X H.Vitamin D status among 0-5 years old children in Jiangsu Province of China[J].Chin J Child Health Care,2020,28(11):1214-1218.(in Chinese) [6] 黄蕾,南楠,刘爱萍,等.甘肃省0~6岁儿童血清25-羟基维生素D水平[J].中国学校卫生,2021,42(12):1803-1805. HUANG L,NAN N,LIU A P,et al.Analysis of serum 25-hydroxyvitamin D levels in children aged 0-6 years in Gansu Province[J].Chin J Sch Health,2021,42(12):1803-1805.(in Chinese) [7] 中华人民共和国国家卫生健康委员会.卫生部办公厅关于印发新生儿访视等儿童保健技术规范的通知[EB/OL].[2024-12-26].http://www.nhc.gov.cn/fys/s3585/201205/da02602bd8b44828abeb3c08358b6794.shtml. [8] 陈荣华,赵正言,刘湘云.儿童保健学[M].5版.南京:江苏凤凰科学技术出版社,2017. CHEN R H,ZHAO Z Y,LIU X Y.Child health care[M].5th edition.Nanjing:Jiangsu Phoenix Science and Technology Press,2017.(in Chinese) [9] 陈赛,陈仁君.儿童25-羟基维生素D水平调查分析[J].中国卫生检验杂志,2021,31(19):2416-2423. CHEN S,CHEN R J.Investigation and analysis of children's 25-hydroxy vitamin D level[J].Chin J Health Lab Tec,2021,31(19):2416-2423.(in Chinese) [10] 谢杰施,陈怡菲,王殊,等.北京地区周岁内婴幼儿维生素D营养状况调查分析[J].标记免疫分析与临床,2024,31(1):16-21,47. XIE J S,CHEN Y F,WANG S,et al.An analysis of vitamin D nutritional status of infants up to one year old in Beijing Region[J].Labeled Immunoassays & Clin Med,2024,31(1):16-21,47.(in Chinese) [11] 余红,程洪,陈晓霞.绍兴地区0~14岁儿童维生素D营养状况评价[J].中国优生与遗传杂志,2021,29(7):1024-1026. YU H,CHENG H,CHEN X X.Evaluation of vitamin D status of children aged 0-14 in Shaoxing[J].Chin J Birth Health & Hered,2021,29(7):1024-1026.(in Chinese) [12] 颜丙辉,李燕,吴琼,等.济南地区1 180例0~6岁儿童维生素D水平观察及其影响因素分析[J].山东医药,2021,61(9):27-30. YAN B H,LI Y,WU Q,et al.Observation of vitamin D level and analysis of its influencing factors in 1 180 children aged 0-6 years in Jinan area[J].Shandong Med J,2021,61(9):27-30.(in Chinese) [13] 杜晓旭,包萨如拉,冯帆,等.维生素D水平与代谢相关脂肪性肝病发生风险的相关性[J].慢性病学杂志,2024,25(6):801-806. DU X X,BAO S R L,FENG F,et al.Correlation between vitamin D levels and the risk of metabolic related fatty liver disease[J].Chron Pathematol J,2024,25(6):801-806.(in Chinese)
