Epidemiological investigation on a case of acute flaccid paralysis with detection of vaccine-derived poliovirus
TANG Xuewen1, BAI Yiran2, SU Ying3, GONG Liming1, YAN Rui1, ZHU Yao1, HE Hanqing1,4
1. Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou, Zhejiang 310051, China; 2. Henan Provincial Center for Disease Control and Prevention, Zhengzhou, Henan 450016, China; 3. Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310053, China; 4. Zhejiang Key Lab of Vaccine, Infectious Disease Control and Prevention, Hangzhou, Zhejiang 310051, China
Abstract：In April 2021, type Ⅰ vaccine-derived poliovirus (VDPV) was detected from two fecal samples of a male infant with acute flaccid paralysis (AFP) in Zhejiang Province when he was admitted to the Children's Hospital Affiliated to Fudan University in Shanghai, with 12 and 14 nucleotide mutations in the VP1 region, respectively. The case had a history of immunization with three doses of poliovirus vaccines, and grade Ⅲ proximal muscle strength and grade Ⅱ distal muscle strength of the right lower limb. After symptomatic treatment, the activity of the right lower limb and the muscle strength was significantly restored, thus he was discharged. VDPV was not detected from subsequent (the 8th to 12th) fecal samples of the case and fecal samples of close contacts. No similar cases were found in medical institutions in the county, surrounding areas, neighboring villages or towns. Since the case did not exhibit clinical symptoms of poliomyelitis caused by VDPV, poliomyelitis was excluded, and the case was diagnosed with hemophilia type A based on the epidemiological investigation, laboratory tests, and the history of poliomyelitis vaccination. This event involved cross-provincial (municipal) cooperation and was responsed promptly, preventing further spread of the virus. It suggested that the sensitivity of the AFP case surveillance system should be maintained, environmental monitoring methods should be increased, and the poliomyelitis vaccination should be promoted to prevent the spread of the virus.
唐学雯, 白祎然, 苏颖, 龚黎明, 严睿, 朱瑶, 何寒青. 一例急性弛缓性麻痹病例检出疫苗衍生脊髓灰质炎病毒的流行病学调查[J]. 预防医学, 2025, 37(2): 178-180,188.
TANG Xuewen, BAI Yiran, SU Ying, GONG Liming, YAN Rui, ZHU Yao, HE Hanqing. Epidemiological investigation on a case of acute flaccid paralysis with detection of vaccine-derived poliovirus. Preventive Medicine, 2025, 37(2): 178-180,188.
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