Research progress on brick-tea type fluorosis in Tibet Plateau
YANG Yi, ZHANG Ru, LI Yonghua
Key Laboratory of Land Surface Pattern and Simulation, Institute of Geographical Sciences and Natural Resources Research, Chinese Academy of Sciences, Beijing 100101, China
Abstract:Tibet Plateau is one of the most prevalent areas of brick-tea type fluorosis in China. Effective management of brick-tea type fluorosis is a key point and a difficulty in endemic disease prevention and treatment in Tibet. Brick-tea type fluorosis is a human health concern that occurs under specific natural environments and social humanistic conditions in Tibet. Recently, the prevalence of brick-tea type fluorosis has been effectively reduced in the Tibet Plateau; however, there are still challenges for the overall brick-tea type fluorosis control, and the endemic status remains more severe than other regions endemic for brick-tea type fluorosis in China. Previous studies have shown that intake of high-fluoride brick-tea, dietary habits of drinking tea and specific natural environments are strongly associated with brick-tea type fluorosis in the Tibet Plateau. This review summarizes the advances in the epidemiological characteristics and influencing factors of brick-tea type fluorosis, so as to provide insights into the development of the long-term control strategy for brick-tea type fluorosis in the Tibet Plateau.
杨依, 张茹, 李永华. 西藏高原饮茶型氟中毒研究进展[J]. 预防医学, 2022, 34(2): 156-160.
YANG Yi, ZHANG Ru, LI Yonghua. Research progress on brick-tea type fluorosis in Tibet Plateau. Preventive Medicine, 2022, 34(2): 156-160.
[1] 龚弘强,何凤珍,赵生成,等.西藏饮茶型氟中毒流行现状调查分析[J].中华地方病学杂志,2018,37(11):889-892. GONG H Q,HE F Z,ZHAO S C,et al.Investigation on the epidemic status of drinking brick-tea type fluorosis in Tibet[J].Chin J Endemiol,2018,37(11):889-892. [2] 李强,赵志军,杨佩珍,等.青海省部分地区饮茶型氟中毒流行现况调查[J].中国公共卫生,2020,36(6):956-958. LI Q,ZHAO Z J,YANG P Z,et al.Prevalence of tea-drinking type fluorosis in some regions of Qinghai province[J].Chin J Public Health,2020,36(6):956-958. [3] 郭敏,尼玛仓决,赵生成,等.西藏自治区地方病防治“十二五”规划终期评估报告[J].中国地方病防治杂志,2016,31(12):1333-1337. [4] LIU X,GAO Y,SUN Y,et al.Prevalence of brick tea-type fluorosis in the Tibet Autonomous Region[J].J Epidemiol,2016,26(2):57-63. [5] VISWANATHAN G,RAJA P B,THIRUMOORTHY K,et al.Pathways of factors exacerbating dental fluorosis risk at high altitude regions-A review[J/OL].Environ Technol Innov,2020,20[2021-12-08].https://doi.org/10.1016/j.eti.2020.101115. [6] 任兴葡,郝得隆,龚弘强,等.温度、煮沸时间和方式对砖茶氟离子溶出影响的实验研究[J].中国地方病防治杂志,2021,36(1):3-6. REN X P,HAO D L,GONG H Q,et al.Experimental study on the influence of temperature,boiling time and method on the dissolution of fluoride ion in brick tea[J].Chin J Control Endemic Dis,2021,36(1):3-6. [7] 曾仁利. 西藏中部农村生产与生活的生态文化研究—以西藏自治区扎囊县扎西林村为例[D].成都:西南民族大学,2018. ZENG R L.Research on the ecological culture of production and living in rural areas in central Tibet-illustrated with Zhaxin Lin Village in Zhanang County Tibet Autonomous Region[D]. Chengdu:Southwest Minzu University,2018. [8] 孙殿军,高彦辉,刘辉,等.做好地方病消除工作,为我国实现全部脱贫目标助力[J].中华地方病学杂志,2017,36(3):157-161. SUN D J,GAO Y H,LIU H,et al.Work hard on elimination of endemic diseases to assist in achieving the goal of all people out of poverty in China[J].Chin J Endemiol,2017,36(3):157-161. [9] 格桑宗吉,土旦,次珍.2017年西藏那曲市比如县饮茶型氟中毒监测结果分析[J].心理月刊,2018(2):161-162. [10] 格桑卓嘎,汤晓佳,西洛.2016—2018年拉萨市饮茶型氟中毒病情调查分析[J].中华地方病学杂志,2020,39(9):658-662. [11] 中华人民共和国卫生部.氟斑牙诊断:WS/T 208—2011[S].北京:中国标准出版社,2011. Ministry of Health of the people's Republic of China.Diagnostic ofr dental fluorosis:WS/T 208-2011[S].Beijing:Standards Press of China,2011. [12] 中国疾病预防控制中心地方病控制中心.2020年度全国饮茶型地方性氟中毒监测报告[R].哈尔滨:中国疾病预防控制中心地方病控制中心,2021. Center for Endemic Disease Control,Chinese Center for Disease Control and Prevention.Annual national monitoring report on brick-tea type of endemic fluorosis in 2020[R].Harbin:Center for Endemic Disease Control,Chinese Center for Disease Control and Prevention,2021. [13] 范淑玲. “十三五”期间我国地方性氟中毒防制现状[J].环境与职业医学,2020,37(12):1219-1223. FAN S L.Current prevention and control of endemic fluorosis during the Thirteenth Five-Year Plan in China[J].J Environ Occup Med,2020,37(12):1219-1223. [14] 中华人民共和国卫生健康委员会.地方性氟骨症临床诊断标准:WS/T 192—2021[S].2021. National Health Commission of the people's Republic of China.Diagnostic standard for endemic skeletal fluorosis:WS/T 192-2021[S].2021. [15] 刘洋,孙静,李丙云,等.我国4个民族饮茶型氟中毒病情差异研究[J].中华地方病学杂志,2014,33(3):315-319. LIU Y,SUN J,LI B Y,et al.The differences of brick-tea fluorosis of four ethnic in China[J].Chin J Endemiol,2014,33(3):315-319. [16] 高彦辉. 地方病防治专项三年攻坚行动方案(2018—2020年)工作任务解读[J].中华地方病学杂志,2019,38(1):1-3. GAO Y H.Interpretation of the tasks of the special three-year program for prevention and control of endemic diseases (2018-2020)[J].Chin J Endemiol,2019,38(1):1-3. [17] 郭宝峰,李程程,梁丽娜,等.砖茶氟含量调查研究[J].中华地方病学杂志,2019,38(6):467-471. GUO B F,LI C C,LIANG L N,et al.Investigation on fluoride content of brick tea[J].Chin J Endemiol,2019,38(6):467-471. [18] 刘盼盼,郑鹏程,龚自明,等.青砖茶中氟及其浸出特性研究[J].食品科技,2018,43(12):90-94. LIU P P,ZHENG P C,GONG Z M,et al.Study on fluorine contents in Qingzhuan tea and its extracting characteristics[J].Food Sci Technol,2018,43(12):90-94. [19] 张佳丽,姚军,仁青措姆,等.西藏昌都市3~5岁儿童龋病及其影响因素调查分析[J].华西口腔医学杂志,2021,39(1):53-57. [20] 何峰,卫郑霞.糌粑中营养成分的测定[J].现代食品,2016(3):106-109. HE F,WEI Z X.The determination of nutrients in Zanba[J].Mod Food,2016(3):106-109. [21] 吴俊华,李丹丹,杨丹,等.饮茶型氟中毒病区藏族与哈萨克族人群尿氟水平与氟暴露程度相关性研究[J].中华地方病学杂志,2015,34(8):549-552. WU J H,LI D D,YANG D,et al.Correlation between urinary fluoride level and i ntaking of fluoride per day in Tibetan and Kazakh population in brick-tea-borne fluorosis areas[J].Chin J Endemiol,2015,34(8):549-552. [22] 陈发虎,傅伯杰,夏军,等.近70年来中国自然地理与生存环境基础研究的重要进展与展望[J].中国科学:地球科学,2019,49(11):1659-1696. CHEN F H,FU B J,XIA J,et al.Major advances in studies of the physical geography and living environment of China during the past 70 years and future prospects[J].Sci China:Earth Sci,2019,49(11):1659-1696. [23] 何志润. 宁夏清水河流域氟化物(F-)的分布特征及其影响因素研究[D].银川:宁夏大学,2020. HE Z R.Study on the distribution chiaracteristics and influencing factor of Fluoride(F-)in Qingshui River Basin of Ningxia[D].Yinchuan:Ningxia University,2020. [24] 秦毅. 青藏高原主要疾病影响因素分析及人体健康风险评价[D].兰州:西北师范大学,2021. QIN Y.Influencing factor of major diseases and human health risk assessment in Qinghai-Tibet Plateau[D].Lanzhou:Northwest Normal University,2021. [25] 秦毅,李倩倩,苏贵金,等.青藏高原地区主要疾病流行特征及健康评价方法[J].环境化学,2021,40(6):1668-1682. QIN Y,LI Q Q,SU G J,et al.Epidemic characteristics of major diseases in the Qinghai-Tibet Plateau region and health assessment methods[J].Environ Chem,2021,40(6):1668-1682. [26] 曲航,尼玛扎西,韦泽秀,等.西藏土壤硒状况与富硒青稞生产路径[J].中国农业科学,2015,48(18):3645-3653. [27] WANG J,L I H R,YANG L S,et al.Distribution and translocation of selenium from soil to highland barley in the Tibetan Plateau Kashin-Beck disease area[J].Environ Geochem Health,2017,39(1):221-229. [28] 陈荣梅,蒋伟东,蒋备战.硒对氟斑牙发生的拮抗作用及其对Beclin1表达的影响[J].同济大学学报(医学版),2020,41(4):426-430. CHEN R M,JIANG W D,JIANG B Z.The antagonistic effect of selenium on dental fluorosis and the expression of Beclin1 in mice[J].J Tongji Univ(Med Sci),2020,41(4):426-430. [29] 索冬卫,陈炅,张玉华,等.硒对过量氟化物致小鼠成釉细胞DNA损伤的拮抗作用[J].中国地方病防治杂志,2016,31(7):811-813. SUO D W,CHEN J,ZHANG Y H,et al.Antagonistic effect of selenium on DNA damage of mouse ameloblasts induced by excessive fluoride[J].Chin J Control Endemic Dis,2016,31(7):811-813. [30] ZHENG X R,SUN Y,KE L L,et al.Molecular mechanism of brain impairment caused by drinking-acquired fluorosis and selenium intervention[J].Environ Toxicol Pharmacol,2016,43:134-139. [31] 申红梅,刘辉.新中国成立70周年地方病防治历程[J].中国地方病防治杂志,2019,34(4):361-363. SHEN H M,LIU H.The course of endemic disease prevention and control in the 70th anniversary of the founding of the People's Republic of China[J].Chin J Control Endemic Dis,2019,34(4):361-363. [32] 石旭东. 茯砖茶氟含量状况调查及降氟措施研究[J].农产品加工,2020(20):65-67. SHI X D.Investigations on the fluoride content of Fuzhuan tea and the measures to reduce fluoride[J].Farm Prod Process,2020(20):65-67. [33] 刘淑娟,钟兴刚,覃事永,等.茶叶氟含量现状及控氟措施研究进展[J].茶叶通讯,2016,43(3):41-45. LIU S J,ZHONG X G,QIN S Y,et al.Review of current situation of fluorine content in tea and research progress in control measures[J]. J Tea Commun,2016,43(3):41-45. [34] 白静,刘庆斌,李海蓉,等.砖茶中氟、铝溶出特性的实验观察[J].中国地方病防治杂志,2015,30(4):243-344. BAI J,LIU Q B,LI H R,et al.Observation of dissolving characteristic of fluoride and aluminium in brick tea[J].Chin J Control Endemic Dis,2015,30(4):243-344. [35] CHEN G J,XIE M H,WAN P,et al.Digestion under saliva,simulated gastric and small intestinal conditions and fermentation in vitro by human intestinal microbiota of polysaccharides from Fuzhuan brick tea[J].Food Chem,2018,244:331-339. [36] XI J,ZHANG L,PENG C,et al.Flavor augmentations affect fluoride bioavailability from brewed dark tea[J].Food Sci Technol-Lebensm-Wiss Technol,2019,109(12):270-275. [37] KRAVCHENKO J,RANGO T,AKUSHEVICH I,et al.The effect of non-fluoride factors on risk of dental fluorosis:evidence from rural populations of the Main Ethiopian Rift[J].Sci Total Environ,2014,488/489:595-606. [38] LEITE G,SAWAN R,TEÓFILO J M,et al.Exposure to lead exacerbates dental fluorosis[J].Arch Oral Biol,2011(56):695-702. [39] 王文彦,桂传枝,官志忠.氟中毒拮抗物的研究进展[J].职业与健康,2021,37(17):2433-2435. WANG W Y,GUI C Z,GUAN Z Z.Advances in studies on antagonists of fluorine[J].Occup Health,2021,37(17):2433-2435.