Abstract:Objective To evaluate enteral nutrition treatment on nutritional status of patients with esophageal cancer during radiotherapy in Chinese population. Methods We searched domestic and foreign relevant databases(PubMed,Medline,Cochrane Library,Wanfang Data,Chinese Journal Database,VMIS) by key words(esophageal cancer,chemoradiotherapy,enteral nutrition),meeting the conditions of the clinical randomized controlled trials,and evaluated the quality of each document. We used meta-analysis method to analysis the published literatures about clinical randomized controlled trials,which were enteral nutrition treatment on nutritional status of patients with esophageal cancer during radiotherapy in Chinese population.RevMan5.1 statistical analysis software were used. Results Seven separate clinical randomized controlled trials including 503 cases were included into the meta-analysis. The following five indexes of nutritional status in enteral nutrition treatment (ENT) group were superior to routine treatment(RT) group(P<0.05):body weight,Body Mass Index(BMI),hemoglobin,serum albumin,serum prealbumin. The MD Values and 95%CI( confidence interval)were 5.54(3.61-7.46),2.20(2.02-2.39),12.46(5.86-19.05),4.04(2.48-5.61),49.53(20.93-78.13).The funnel plot showed no significant publication bias in each indexes. Conclusion Enteral nutrition treatment can improve the nutritional status of patients with esophageal cancer during radiotherapy compare only with routine treatment.
邱恩毅, 赵喜越, 金璋, 林权冰. 肠内营养治疗对改善中国食管癌放疗患者营养状况的Meta分析[J]. 预防医学, 2018, 30(2): 153-157.
QIU En-yi, ZHAO Xi-yue, JIN Zhang, LIN Quan-bing. Enteral nutrition treatment on nutritional status of patients with esophageal cancer during radiotherapy in Chinese population:a meta-analysis. Preventive Medicine, 2018, 30(2): 153-157.
[1] CHEN W,ZHENG R,BAADE P D,et al. Cancer statistics in China,2015[J]. CA Cancer J Clin,2016,66(2):115-132. [2] 中国非手术治疗食管癌临床分期专家小组. 非手术治疗食管癌的临床分期标准(草案)[J]. 中华放射肿瘤学杂志,2010,19(3):179-180. [3] FERLAY J,SHIN H R,BRAY F,et al. Estimates of worldwide burden of cancer in 2008:GLOBOCAN 2008[J]. Int J Cancer,2010,127(12):2893-2917. [4] MINSKY B D. INT 0123(Radiation Therapy Oncology Group 94-05) Phase III trial of combined-modality therapy for esophageal cancer:high-dose versus standard-dose radiation therapy[J]. Journal of Clinical Oncology,2002,20(5):1167-1174. [5] CLAVIER J B,ANTONI D,ATLANI D,et al. Baseline nutritional status is prognostic factor after definitive radiochemotherapy for esophageal cancer[J]. Dis Esophagus,2014,27(6):560-567. [6] 徐林友,吴斌,洪伟. 食管癌患者术后早期肠内营养的疗效观察[J]. 中华全科医学,2012,10(2):231,233. [7] ODELLI C,BURGESS D,BATEMAN L,et al. Nutrition support improves patient outcomes,treatment tolerance and admission characteristics in oesophageal cancer[J]. Clin Oncol (R Coll Radiol),2005,17(8):639-645. [8] 拱玉华,郭占文,周建萍,等. 营养支持对64例食管癌患者放射治疗结局的影响[J]. 中国临床营养杂志,2005,13(6):361-363. [9] 杨光凡,王淑君,胡晓翠,等. 103例食管癌患者放疗期间的营养支持分析[J]. 湖南师范大学学报(医学版),2010,7(4):45-47. [10] 丛明华,李淑娈,程国威,等. 营养支持小组对于食管癌同步放化疗患者作用的研究[J]. 中国肿瘤临床,2014,41(18):1158-1162. [11] 马虎,马吉,张钰,等. 积极营养支持在食管癌同期放化疗中的应用[C]. 2014《中国国际肿瘤营养学论坛》暨第二届《全国肿瘤营养与支持治疗学术会议》论文集,2014:150-152. [12] 陈超,李华峰. 肠内营养支持治疗对食管癌放化疗疗效的影响[J]. 浙江中西医结合杂志,2014,24(7):611-612. [13] 赵大奇. 肠内营养支持对食管癌患者放疗后营养状况和免疫功能的影响[J]. 当代医学,2015,21(35):80-81. [14] 高彤,王晓燕,赵丽霞,等. 营养干预对食管癌同步放化疗患者的影响[J]. 检验医学与临床,2015,12(13):1944-1946. [15] 马艳会,周玉华,曹继娟. 食管癌放化疗患者进行营养干预的效果研究[J]. 中国民康医学,2016,28(9):99-101. [16] 吕家华,李涛,谢丛华,等. 食管癌放疗患者肠内营养专家共识[J/CD]. 肿瘤代谢与营养电子杂志,2015,2(4):29-32. [17] 刘辉,黄春萍,王玲莉. 杭州地区居民膳食营养状况调查[J]. 浙江预防医学,2015,27(12):1221-1225. [18] UNAL D,ORHAN O,EROGLU C,et al. Prealbumin is a more sensitive marker than albumin to assess the nutritional status in patients undergoing radiotherapy for head and neck cancer[J]. Contemp Oncol (Pozn),2013,17(3):276-280.