Effects of overweight and obesity or central obesity comorbid with hyperuricemia on dyslipidemia among the elderly
WU Mengyi, HU Jinsong, HUANG Shuang, HUANG Yuanxiu
Changsha Center for Disease Control and Prevention (Changsha Municipal Bureau of Comprehensive Health Supervision and Law Enforcement), Changsha, Hunan 410004, China
Abstract：Objective To analyze the effects of overweight and obesity or central obesity comorbid with hyperuricemia on dyslipidemia among the elderly, so as to provide evidence for early identification, high-risk population screening and precise intervention of dyslipidemia among the elderly. Methods Based on the National Basic Public Health Service Program, the elderly aged ≥65 years in Changsha City were selected as study participants. Data on gender, age, body mass index, waist circumference, total cholesterol, triglycerides and serum uric acid were collected through the Hunan Provincial Primary Health Information System. A multivariable logistic regression model was used to analyze the effects of overweight and obesity or central obesity comorbid with hyperuricemia on dyslipidemia among the elderly. The Excel sheet compiled by Andersson et al. was used to calculate the relative excess risk due to interaction (RERI), the attributable proportion due to interaction (AP) and the synergy index (SI). Results A total of 1 755 participants were included, including 833 males (47.46%) and 922 females (52.54%). The median age was 73.00 (interquartile range, 9.00) years. A total of 597 participants had overweight and obesity (34.02%), 583 had central obesity (33.22%), and 323 had hyperuricemia (18.40%). Dyslipidemia was detected in 663 participants, with a detection rate of 37.78%. Multivariable logistic regression analysis showed that overweight and obesity (OR=2.734, 95%CI: 2.207-3.386), central obesity (OR=2.665, 95%CI: 2.152-3.301), hyperuricemia (OR=2.459, 95%CI: 1.910-3.165), overweight and obesity combined with hyperuricemia (OR=5.417, 95%CI: 3.741-7.843) and central obesity combined with hyperuricemia (OR=5.307, 95%CI: 3.633-7.751) were statistically associated with a higher risk of dyslipidemia among the elderly. Interaction analysis showed that there was an additive interaction between overweight and obesity and hyperuricemia on dyslipidemia among the elderly (RERI=1.568, 95%CI: 0.371-2.765; AP=0.289, 95%CI: 0.068-0.510; SI=1.550, 95%CI: 1.135-2.116), and an additive interaction between central obesity and hyperuricemia on dyslipidemia among the elderly (RERI=1.303, 95%CI: 0.115-2.491; AP=0.246, 95%CI: 0.022-0.470; SI=1.434, 95%CI: 1.045-1.968). Conclusion Interaction effects of overweight and obesity or central obesity comorbid with hyperuricemia on dyslipidemia among the elderly were observed and may increase the risk of dyslipidemia.
吴梦怡, 胡劲松, 黄霜, 黄渊秀. 超重肥胖或中心性肥胖与高尿酸血症共病对老年人血脂异常的影响[J]. 预防医学, 2026, 38(10): 973-976,983.
WU Mengyi, HU Jinsong, HUANG Shuang, HUANG Yuanxiu. Effects of overweight and obesity or central obesity comorbid with hyperuricemia on dyslipidemia among the elderly. Preventive Medicine, 2026, 38(10): 973-976,983.
