Latent tuberculosis infection among middle school students in Yuhang District
MENG Xiangjie1, TANG Yin1, SHOU Jun1, SUN Mingxi1, ZHANG Yu2
1. Yuhang District Center for Disease Control and Prevention (Yuhang District Institute of Public Health Supervision), Hangzhou, Zhejiang 311113, China; 2. Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou, Zhejiang 310051, China
Abstract:Objective To explore the current situation and influencing factors of latent tuberculosis infection (LTBI) among middle school students in Yuhang District, Hangzhou City, so as to provide evidence for optimizing targeted school tuberculosis prevention and control strategies. Methods The study targeted students in grades 7 through 11 in Yuhang District from 2023 to 2025. LTBI screening was conducted annually from September to November using the tuberculin skin test. Basic data, such as the year of screening and gender, were collected through the Yuhang District Public Health Emergency Intelligent Control System, while information on school type and boarding status was gathered from the schools themselves. A multivariable logistic regression model was used to analyze the influencing factors for LTBI among middle school students. Results A total of 102 092 person-tims middle school students were screened, including 54 015 person-tims of boys (52.91%) and 48 077 person-tims of girls (47.09%). LTBI was detected in 6 913 person-tims, with a detection rate of 6.77%. Multivariable logistic regression analysis showed that screenings conducted in 2024-2025 (2024, OR=1.123, 95%CI: 1.055-1.196; 2025, OR=1.255, 95%CI: 1.181-1.334), girls (OR=1.146, 95%CI: 1.092-1.204), and students in grades 8 through 11 (grade 8, OR=1.707, 95%CI: 1.588-1.836; grade 9, OR=1.634, 95%CI: 1.515-1.762; grade 10, OR=1.713, 95%CI: 1.574-1.864; grade 11, OR=1.691, 95%CI: 1.549-1.846) had a higher risk of LTBI; students in boarding schools (OR=0.619, 95%CI: 0.575-0.666) had a lower risk of LTBI. Conclusion The prevalence of LTBI among middle school students in Yuhang District is relatively high, primarily due to the year of screening, gender, grade level, and boarding school.
[1] World Health Organization,Global tuberculosis report 2025[R/OL].[2026-04-22].https://www.who.int/teams/global-programme-on-tuberculosis-and-lung-health/tb-reports/global-tuberculosis-report-2025. [2] 徐彩红,赵雁林,夏愔愔,等.中国结核病预防性治疗指南[M].北京:人民卫生出版社,2023. [3] 贾雪娇,胡远莲,张东彦,等.一起寄宿学校肺结核聚集性疫情调查分析[J].结核与肺部疾病杂志,2023,4(1):13-19. [4] 中华人民共和国中央人民政府.中国学校结核病防控指南(2020年版)[EB/OL].[2026-04-22].http://www.gov.cn/zhengce/zhengceku/2020-12/05/content_5567137.htm. [5] 明瑶,陈明慧,王芳,等.中国在校生结核分枝杆菌潜伏感染率及预防性治疗意愿的Meta分析[J].中国防痨杂志,2025,47(12):1556-1565. [6] 中华人民共和国国家卫生和计划生育委员会.肺结核诊断:WS 288—2017[S].北京:中国标准出版社,2017. [7] 王文瑾,刘巧,缪昌东,等.2019—2021年泰州市中学新生结核潜伏感染现况及影响因素[J].中华疾病控制杂志,2022,26(11):1264-1270. [8] 肖涛,王巧智,徐祖辉,等.长沙市城区中学生结核病筛查感染情况分析[J].实用预防医学,2022,29(11):1295-1298. [9] 王坤鹏,何晶晶,赵永年,等.2020年新疆生产建设兵团第三师中小学结核分枝杆菌感染筛查情况分析[J].结核与肺部疾病杂志,2022,3(2):148-152. [10] 曾源鸿,陈朝琼,杨煊镔,等.2023年高县学生结核分枝杆菌感染情况调查分析[J].预防医学情报杂志,2024,40(7):761-766. [11] 吴蕴华,苏华林,唐利红,等.分类筛查在上海市闵行区入学新生肺结核筛查中的应用[J].中国初级卫生保健,2020,34(11):63-65. [12] 尹立,张雯.太原市某区4所高中2016年—2018年入学新生结核病筛查结果分析[J].护理研究,2020,34(14):2589-2592. [13] 赵鑫,张亚楠,闫银,等.2020—2022年北京市大学和高中学段新生结核菌素皮肤试验反应特征分析[J].中国防痨杂志,2024,46(1):40-44. [14] KIM H W,MIN J,CHOI J Y,et al.Prevalence of latent tuberculosis infection among participants of the national LTBI screening program in South Korea:a problem of low coverage rate with current LTBI strategy[J/OL].Front Public Health,2022,10[2026-04-22].http://doi.org/10.3389/fpubh.2022.1066269. [15] 申晨,申阿东.结核病发病率的性别差异性研究现状[J].结核病与肺部健康杂志,2017,6(4):381-385. [16] WANG Z,POSEY D L,BROSTROM R J,et al.US postarrival evaluation of immigrant and refugee children with latent tuberculosis infection diagnosed overseas,2007-2019[J].J Pediatr,2022,245:149-157. [17] 吕阳,乐博昕,胡伟宏,等.肺结核密切接触学生结核分枝杆菌潜伏感染的影响因素分析[J].预防医学,2024,36(8):658-662. [18] HANG Z,WU G,YU A,et al.Epidemiological characteristics and influencing factors of tuberculosis aggregation in schools in Wuhan,China during 2017-2022[J/OL].Front Public Health,2024,12[2026-04-22].http://doi.org/10.3389/fpubh.2024.1365983.