Abstract：Objective To analyze the influencing factors for anterior tibial artery atherosclerosis among patients with hyperuricemia, so as to provide insights into the prevention of anterior tibial artery atherosclerosis. Methods Patients aged 18 years and older with hyperuricemia in Dazhou Integrated TCM & Western Medicine Hospital were enrolled as research subjects from 2020 to 2023. Demographic information and blood biochemistry indicators were collected through electronic medical records. Anterior tibial artery atherosclerosis was evaluated by color Doppler ultrasound. Factors affecting anterior tibial artery atherosclerosis among patients with hyperuricemia were analyzed by a multivariable logistic regression model. Results A total of 1 105 patients with hyperuricemia were surveyed, including 862 males (78.01%) and 243 females (21.99%). There were 918 cases (83.08%) at the ages of 60 years and older, and 457 cases (41.36%) with a course of disease at 10 years and longer. The median level of blood uric acid was 480.79 (interquartile range, 98.28) μmol/L. There were 314 cases (28.42%) with anterior tibial artery atherosclerosis. Multivariable logistic regression analysis showed that body mass index (≥24.0 kg/m2, OR=1.597, 95%CI: 1.185-2.151), long-term smoking history (yes, OR=1.709, 95%CI: 1.153-2.534), diabetes mellitus (yes, OR=1.517, 95%CI: 1.162-1.981), serum uric acid (≥480.79 μmol/L, OR=1.667, 95%CI: 1.131-2.457), serum creatinine (≥97 μmol/L, OR=1.685, 95%CI: 1.155-2.460), fasting blood glucose (≥6.1 mmol/L, OR=1.528, 95%CI: 1.106-2.112), fibrinogen (>4 g/L, OR=1.589, 95%CI: 1.091-2.315) and triglycerides (≥1.7 mmol/L, OR=1.879, 95%CI: 1.226-2.881) were influencing factors for anterior tibial artery atherosclerosis among patients with hyperuricemia. Conclusion Anterior tibial artery atherosclerosis among patients with hyperuricemia is associated with long-term smoking, diabetes mellitus, serum uric acid, serum creatinine, fasting blood glucose, fibrinogen and triglycerides high level.
[1] 林淑芃. 《中国高尿酸血症与痛风诊疗指南(2019)》解读[J].临床内科杂志,2020,37(6):460-462. LIN S F.Interpretation of the 2019 Chinese Guideline for the Diagnosis and Treatment of Hyperuricemia and Gout[J].J Clin Intern Med,2020,37(6):460-462.(in Chinese) [2] KIMURA Y,TSUKUI D,KONO H.Uric acid in inflammation and the pathogenesis of atherosclerosis[J].Int J Mol Sci,2021,22(22):1-19. [3] 周正雅,柴玉琼,袁晶,等.成人血尿酸水平与冠状动脉粥样硬化性心脏病的关联分析[J].公共卫生与预防医学,2023,34(1):141-143. ZHOU Z Y,CHAI Y Q,YUAN J,et al.Relationship between uric acid and coronary atherosclerotic heart disease in adults[J].J Pub Health Prev Med,2023,34(1):141-143.(in Chinese) [4] 徐东,殷婷,谢旭品,等.血尿酸联合单核细胞趋化因子1对下肢动脉硬化闭塞患者的诊断价值[J].心脑血管病防治,2020,20(6):622-624,628. XU D,YIN T,XIE X P,et al.Diagnostic value of serum uric acid combined with monocyte chemotactic protein-1 in patients with lower extremity arterial occlusion[J].Cardio-Cerebrovasc Dis Prev Treat,2020,20(6):622-624,628.(in Chinese) [5] 中华医学会内分泌学分会.中国高尿酸血症与痛风诊疗指南(2019)[J].中华内分泌代谢杂志,2020,36(1):1-13. Chinese Society of Endocrinology,Chinese Medical Association.Guideline for the diagnosis and management of hyperuricemia and gout in China(2019)[J].Chin J Endocrinol Metab,2020,36(1):1-13.(in Chinese) [6] HOMMA S,HIROSE N,ISHIDA H,et al.Carotid plaque and intima-media thickness assessed by b-mode ultrasonography in subjects ranging from young adults to centenarians[J].Stroke,2001,32(4):830-835. [7] 冯可欣,郑启健,吕康,等.血脂及血尿酸对颈动脉粥样硬化发生风险的交互作用研究[J].中国脑血管病杂志,2022,19(10):667-676. FENG K X,ZHENG Q J,LYU K,et al.Interaction of blood lipid and serum uric acid on the risk of carotid atherosclerosis[J].Chin J Cerebrovasc Dis,2022,19(10):667-676.(in Chinese) [8] 方堃,丁岩,霍康.超重/肥胖与血浆致动脉粥样硬化指数及其交互作用对45岁及以上人群2型糖尿病患病风险的影响[J].郑州大学学报(医学版),2023,58(4):489-493. FANG K,DING Y,HUO K.Interaction between overweight/obesity and atherogenic index of plasma on risk of type 2 diabetes mellitus for population with age ≥45 years[J].J Zhengzhou Univ(Med Sci),2023,58(4):489-493.(in Chinese) [9] 杨烁,于波.吸烟与他汀类药物疗效在冠状动脉粥样硬化中的相互影响[J].心血管康复医学杂志,2021,30(3):366-370. YANG S,YU B.Interaction between smoking and statins in coronary atherosclerosis[J].Chin J Cardiovasc Rehabil Med,2021,30(3):366-370.(in Chinese) [10] 姚翡,郁秋荣,龚叶,等.2型糖尿病并发高尿酸血症患者血尿酸与粒淋比、γ-谷氨酰转肽酶的相关性及HUA发生的因素[J].河北医科大学学报,2022,43(10):1147-1152. YAO F,YU Q R,GONG Y,et al.Correlation between serum uric acid,neutrophil-to-lymphocyte ratio and γ-glutamyl transpeptidase in patients with type 2 diabetes mellitus complicated with hyperuricemia and the influencing factors of hyperuricemia[J].J Hebei Med Univ,2022,43(10):1147-1152.(in Chinese) [11] LEE T S,LU T M,CHEN C H,et al.Hyperuricemia induces endothelial dysfunction and accelerates atherosclerosis by disturbing the asymmetric dimethylarginine/dimethylarginine dimethylaminotransferase 2 pathway[J].Redox Biol,2021,46:1-9. [12] 王少慧,刘鉴文,曾志伟.老年2型糖尿病合并高尿酸血症患者糖化血红蛋白、胱抑素C水平及其与血尿酸、血肌酐相关性分析[J].中国现代医药杂志,2021,23(2):73-75. WANG S H,LIU J W,ZENG Z W.Correlation analysis of glycated hemoglobin,cystatin C levels,and their relationship with serum uric acid and serum creatinine in elderly patients with type 2 diabetes mellitus complicated by hyperuricemia[J].MMJC,2021,23(2):73-75.(in Chinese) [13] 刘淑党,林静娜,邱慧娜,等.2型糖尿病患者血尿酸水平与发生动脉粥样硬化性心血管疾病事件风险的影响研究[J].中国糖尿病杂志,2022,30(4):241-245. LIU S D,LIN J N,QIU H N,et al.Effect of serum uric acid level on the risk of ASCVD in patients with type 2 diabetes mellitus[J].Chin J Diabetes,2022,30(4):241-245.(in Chinese) [14] 范为群,罗文良,邵布勒,等.直接胆红素和血脂对颈动脉粥样硬化及颈动脉斑块发生风险的交互作用[J].预防医学,2020,32(6):563-568. FAN W Q,LUO W L,SHAO B L,et al.The interaction between direct bilirubin and blood lipids on carotid atherosclerosis and carotid plaque[J].China Prev Med J,2020,32(6):563-568.(in Chinese)
