Mediating effect of nighttime sleep duration on pain and frailty among elderly patients with comorbidity of chronic diseases
LI Siqi1, ZENG Yangjing1, WANG Xuejiao2, JU Xinmei1
1. School of International Nursing, Hainan Medical University, Haikou, Hainan 571199, China; 2. The First Affiliated Hospital of Hainan Medical University, Haikou, Hainan 570102, China
Abstract：Objective To examine the mediating effect of nighttime sleep duration on pain and frailty among elderly patients with comorbidity of chronic diseases, so as to provide insights into frailty control among the elderly. Methods Demographic information, pain and nighttime sleep duration of the elderly at ages of 60 years and older were collected from the China Health and Retirement Longitudinal Study 2020. Frailty were evaluated using frailty index. The mediating effect of sleep duration for pain and frailty was analyzed using the Process program compiled by HAYSS and colleagues, and the significance of the mediating role was tested using the Bootstrap test. Results A total of 2 246 elderly patients with comorbidity of chronic diseases were enrolled, including 1 195 males (53.21%) and 1 051 females (46.79%), with a median age of 65.00 (interquartile range, 8.00) years. There were 504 cases with frailty (22.44%), with a median pain score of 0 (interquartile range, 1.00) points, and a mean nighttime sleep duration of (6.44±1.55) hours. Mediating analysis showed that pain affected frailty directly and positively with the effect value of 0.089 (95%CI: 0.066-0.112), and also affected frailty by nighttime sleep duration directly and positively with the effect value of 0.047 (95%CI: 0.036-0.058), with the mediating effect contributed 34.56% of the total effect. Conclusion Pain can directly or indirectly affect frailty among elderly patients with comorbidity of chronic diseases through nighttime sleep duration.
李思琦, 曾洋菁, 王雪娇, 琚新梅. 老年慢性病共病患者夜间睡眠时长在疼痛与衰弱间的中介效应分析[J]. 预防医学, 2024, 36(8): 645-648.
LI Siqi, ZENG Yangjing, WANG Xuejiao, JU Xinmei. Mediating effect of nighttime sleep duration on pain and frailty among elderly patients with comorbidity of chronic diseases. Preventive Medicine, 2024, 36(8): 645-648.
[1] 刘冬阳,黄昕彤,赖晋锋,等.中国中老年人慢性病共病流行趋势研究[J].中国慢性病预防与控制,2024,32(4):244-249. [2] 曹丰,王亚斌,薛万国,等.中国老年疾病临床多中心报告[J].中华老年多器官疾病杂志,2018,17(11):801-808. [3] AYALA J C,GRISMALDO A,SEQUEDA-CASTAÑEDA L G,et al.Oxidative stress in ICU patients: ROS as mortality long-term predictor[J/OL].Antioxidants(Basel),2021,10(12)[2024-07-31].https://doi.org/10.3390/antiox10121912. [4] 赵婷,张艳,吴兰心,等.社区共病老年人居家疾病体验的质性研究[J].中国全科医学,2024,27(25):3143-3149. [5] JIAO X W,WANG R Y,DING X B,et al.LncRNA-84277 is involved in chronic pain-related depressive behaviors through miR-128-3p/SIRT1 axis in central amygdala[J/OL].Front Mol Neurosci,2022,15[2024-07-31].https://doi.org/10.3389/fnmol.2022.920216. [6] LI X,XUE Q Y,YI X T,et al.The interaction of occupational stress, mental health, and cytokine levels on sleep in Xinjiang oil workers: a cross-sectional study[J/OL].Front Psychiatry,2022,13[2024-07-31].https://doi.org/10.3389/fpsyt.2022.924471. [7] 张栗,周省,王蓓佳,等.中老年抑郁症状人群物影响因素研究[J].预防医学,2024,36(2):115-118. [8] 申莉,贾光耀,李佳遇,等.基于中国健康与养老追踪调查的老年人疼痛、睡眠与抑郁关系研究[J].中国预防医学杂志,2023,24(2):156-160. [9] 林静静,杜雨珊,梁明斌,等.中老年人衰弱与生活行为因素的关联研究[J].预防医学,2022,34(3):263-267. [10] SATHYAN S,AYERS E,GAO T,et al.Plasma proteomic profile of frailty[J/OL].Aging Cell,2020,19(9)[2024-07-31].https://doi.org/10.1111/acel.13193. [11] 王世强,郭凯林,吕万刚.体力活动对中国老年人衰弱的影响——基于中国健康与养老追踪调查的实证分析[J].成都体育学院学报,2023,49(5):114-122. [12] STEVENSON J M,PAREKH N,CHUA KC,et al.A multi-centre cohort study on healthcare use due to medication-related harm: the role of frailty and polypharmacy[J/OL].Age Ageing,2022,51(3)[2024-07-31].https://doi.org/10.1093/ageing/afac054. [13] 郭凯林,王世强,李丹,等.我国老年人衰弱的发展轨迹:基于潜变量增长模型的分析[J].中国全科医学,2022,25(6):742-749,755. [14] GOBBENS R J,LUIJKX K G,WIJNEN-SPONSELEE M T,et al. Towards an integral conceptual model of frailty[J].J Nutr Health Aging,2010,14(3):175-181. [15] WU C,SMIT E,XUE Q L,et al.Prevalence and correlates of frailty among community-dwelling Chinese older adults:the China health and retirement longitudinal Study[J].J Gerontol A Biol Sci Med Sci,2017,73(1):102-108. [16] NAKAI Y,MAKIZAKO H,KIYAMA R,et al.Association between chronic pain and physical frailty in community-dwelling older adults[J].Int J Environ Res Public Health,2019,16(8)[2024-07-31].Association between chronic pain and physical frailty in community-dwelling older adults[J].Int J Environ Res Public Health,2019,16(8)[2024-07-31].http://doi.org/10.3390/ijerph16081330. [17] ZHANG Q,YU M,TANG R R,et al.A pathway model of chronic pain and frailty in older Chinese cancer patients:the mediating effect of sleep[J].Geriatr Nurs,2023,50:215-221. [18] 吴丹,胡雅,李丽君,等.老年人衰弱与慢性疼痛关系的研究进展[J].护理研究,2021,35(15):2738-2741. [19] 戚凯丽,李洁,袁叶敏,等.老年人慢性疼痛与多维度衰弱相关研究进展[J].中华疾病控制杂志,2023,27(6):711-716,721. [20] 施博文,熊巨洋.慢性病共病对中国老年人健康相关生命质量的影响研究[J].人口与发展,2024,30(1):120-128. [21] POURMOTABBED A,BOOZARI B,BABAEI A,et al.Sleep and frailty risk: a systematic review and meta-analysis[J].Sleep Breath,2020,24(2):1187-1197. [22] 黄文,汤佳良,陈康康,等.高血压合并糖尿病患者睡眠质量调查[J].预防医学,2024,36(4):296-298,303.
