Factors affecting concurrent sarcopenia among patients with cardiovascular diseases
MA Runze1, SHI Fang2, LI Hongquan2, LÜ Mengzhu2, Nuerbiyamu Aiheti1, TIAN Xiaoli2, CHEN Simin1, YAN Shikang1, Kaidiriyan Kuribanjiang1, YANG Lei1,4
1. School of Public Health, Xinjiang Medical University, Urumqi, Xinjiang 830054, China; 2. The Sixth Division Hospital of Xinjiang Production and Construction Corps, Wujiaqu, Xinjiang 831300, China; 3. Xinjiang Second Medical College, Karamay, Xinjiang 834000, China; 4. State Key Laboratory of Causes and Prevention of High Incidence in Central Asia, Urumqi, Xinjiang 830011, China
Abstract：Objective To investigate the factors affecting concurrent sarcopenia among patients with cardiovascular diseases, so as to provide insights into early identification and prevention of cardiovascular diseases complicated with sarcopenia. Methods A total of 250 inpatients with cardiovascular diseases in the Sixth Division Hospital of Xinjiang Production and Construction Corps were recruited and divided into the sarcopenia and non-sarcopenia groups according to the diagnostic criteria of sarcopenia. Subjects' basic characteristics, body mass index, blood biochemical indicators and human body composition parameters were collected using questionnaire surveys, and factors affecting concurrent sarcopenia among patients with cardiovascular diseases using a multivariable logistic regression model. Results Among the 250 patients with cardiovascular diseases, there were 149 males (59.60%) and 101 females (40.40%). The overall prevalence of sarcopenia was 8.40% among the study subjects. The mean age and body mass index were (75.19±9.74) and (20.77±2.19) kg/m2 in the sarcopenia group and (65.24±11.50) years and (25.85±2.87) kg/m2 in the non-sarcopenia group. Multivariable logistic regression analysis identified age (OR=1.115, 95%CI: 1.030-1.207) and body mass index (OR=0.582, 95%CI: 0.445-0.761) were as factors affecting concurrent sarcopenia among patients with cardiovascular diseases. Conclusion Advanced age and low body mass index may increase the risk of concurrent sarcopenia among patients with cardiovascular diseases.
[1] CHEN L K,WOO J,ASSANTACHAI P,et al.Asian Working Group for Sarcopenia:2019 consensus update on sarcopenia diagnosis and treatment[J]. J Am Med Dir Assoc,2020,21(3):300-307. [2] 路晓芳,黄丽红,秦迪,等.肌肉减少症与心血管疾病关系的研究进展[J]. 中国实验诊断学,2022,26(5):769-772. [3] ZUO X R,LI X H,TANG K,et al.Sarcopenia and cardiovascular diseases:a systematic review and meta-analysis[J]. J Cachexia Sarcopenia Muscle,2023,14(3):1183-1198. [4] 屈红蕾,海荣,王静,等.少肌症与心血管疾病相关性研究进展[J]. 内蒙古医科大学学报,2019,41(6):667-669. [5] 王家欣,方业贤,佘林聪,等.肌少症与心血管疾病相关性的研究现状[J]. 中国心血管病研究,2023,21(1):61-66. [6] IUNG B.NYHA functional class in secondary mitral regurgitation:an old classification to evaluate an innovative technique[J]. JACC Cardiovasc Interv,2020,13(20):2329-2330. [7] HARADA H,KAI H,SHIBATA R,et al.New diagnostic index for sarcopenia in patients with cardiovascular diseases[J/OL]. PLoS One,2017,12(5)[2023-10-19]. https://doi.org/10.1371/journal.pone.0178123. [8] YALCIN A,ARAS S,ATMIS V,et al.Sarcopenia prevalence and factors associated with sarcopenia in older people living in a nursing home in Ankara Turkey[J]. Geriatr Gerontol Int,2016,16(8):903-910. [9] VON HEAHLING S,EBNER N,DOS SANTOS M R,et al. Muscle wasting and cachexia in heart failure: mechanisms and therapies[J]. Nat Rev Cardiol,2017,14(6):323-341. [10] SASAKI K I.The prevalence of sarcopenia and subtypes in cardiovascular diseases,and a new diagnostic approach[J]. J Cardiol,2020,76(3):266-272. [11] 汪亚男,宋红玲,顾艳荭,等. 老年2型糖尿病患者合并肌少症影响因素分析[J]. 预防医学,2019,31(6):582-585. [12] GAO K,CAO L F,MA W Z,et al.Association between sarcopenia and cardiovascular disease among middle-aged and older adults:findings from the China health and retirement longitudinal study[J]. EClinicalMedicine,2022,44:1-11. [13] 王俊苹,卢肇骏,寇硕,等. 基于CHARLS的中国老年人体质指数与死亡风险研究[J]. 预防医学,2022,34(4):346-349. [14] WANNAMETHEE S G,ATKINS J L.Muscle loss and obesity:the health implications of sarcopenia and sarcopenic obesity[J]. Proc Nutr Soc,2015,74(4):405-412. [15] ZAMBONI M,RUBELE S,ROSSI A P.Sarcopenia and obesity[J]. Curr Opin Clin Nutr Metab Care,2019,22(1):13-19.
