Association between chronic hepatitis B virus infection anddiabetes among adults
WANG Hao*, CHEN Lingli, XIE Kaixu, WANG Chunmei, CAO Yuan, SHEN Dun, ZHANG Xiaoyi, ZHU Shuiqing, HU Ruying, BIAN Zheng, GUO Yu, YU Min, CHEN Zhengming, LI Liming
* Department of Non-communicable Diseases Control and Prevention, Zhejiang Provincial Center for Diseases Control and Prevention, Zhejiang, Hangzhou 310051, China
Abstract：Objective To explore the association between chronic hepatitis B virus infection and diabetes among adults. Methods The baseline data of China Kadoorie Biobank ( CKB ) study from Tongxiang of Zhejiang Province was used for analysis. Community residents were investigated in the study from August 2004 to May 2008, including questionnaire survey, physical measurement and biological sample test. Univariate and multivariate logistic regression models were used to estimate the association of chronic hepatitis B virus infection with diabetes. Results Totally 52 888 participants were included in the final analysis. The overall prevalence of HBsAg-positive was 3.55% ( N=1 877 ). The overall prevalence of diabetes was 5.17% ( N=2 733 ). The prevalence of HBsAg-positive in diabetic patients was 3.51% ( N=96 ). Both univariate and multivariate logistic regression models indicated that there was no association between chronic hepatitis B virus infection and diabetes（ P>0.05 ）. Conclusion No significant association has been found between chronic hepatitis B virus infection and diabetes among adults.
[1] International Diabetes Federation. The IDF Diabetes Atlas, 8th Edition [EB/OL].(2019-10-10)[2020-09-28]. https://diabetesatlas.org/across-the-globe.html. [2] 李立明,饶克勤,孔灵芝,等. 中国居民2002年营养与健康状况调查[J]. 中华流行病学杂志,2005,26(7):478-484. [3] RAMACHANDRAN A,MA R C,SNEHALATHA C.Diabetes in Asia[J].Lancet,2010,375(9712):408-418. [4] WANG L,GAO P,ZHANG M,et al.Prevalence and ethnic pattern of diabetes and prediabetes in China in 2013[J]. JAMA,2017,317(24):2515-2523. [5] SCHWEITZER A,HORN J,MIKOLAJCZYK R T,et al.Estimations of worldwide prevalence of chronic hepatitis B virus infection: a systematic review of data published between 1965 and 2013[J].Lancet,2015,386(10003):1546-1555. [6] LIANG X F,BI S L,YANG W Z,et al.Epidemiological serosurvey of hepatitis B in China--declining HBV prevalence due to hepatitis B vaccination[J].Vaccine,2009,27(47):6550-6557. [7] The Polaris Observatory Collaborators.Global prevalence, treatment, and prevention of hepatitis B virus infection in 2016: a modelling study[J].Lancet Gastroenterol Hepatol,2018,3(6):383-403. [8] CUSTRO N,CARROCCIO A,GANCI A,et al.Glycemic homeostasis in chronic viral hepatitis and liver cirrhosis[J]. Diabetes Metab,2001,27(4):476-481. [9] LI-NG M,TROPP S,DANOFF A,et al.Association between chronic hepatitis B virus infection and diabetes among Asian Americans and Pacific Islanders[J].Dig Liver Dis,2007,39(6):549-556. [10] JAN C F,CHEN C J,CHIU Y H,et al.A population-based study investigating the association between metabolic syndrome and hepatitis B/C infection(Keelung Community-based Integrated Screening study No. 10 )[J].Int J Obes (Lond),2006,30(5):794-799. [11] CHEN H F,LI C Y,CHEN P,et al.Seroprevalence of hepatitis B and C in type 2 diabetic patients[J].J Chin Med Assoc,2006,69(4):146-152. [12] HONG Y S,CHANG Y,RYU S,et al.Hepatitis B and C virus infection and diabetes mellitus:a cohort study[J]. Sci Rep,2017,7(1):4606. [13] HUANG Z S,HUANG T S,WU T H,et al.Asymptomatic chronic hepatitis B virus infection do3s not increase the risk of diabetes mellitus: a ten-year observation[J].J Gastroenterol Hepatol,2010,25(8):1420-1425. [14] CHEN Z,LEE L,CHEN J,et al.Cohort profile: the Kadoorie Study of Chronic Disease in China(KSCDC)[J].In J Epidemiol,2005,34(6):1243-1249. [15] CHEN Z,CHEN J,COLLINS R,et al.China Kadoorie Biobank of 0.5 million people: survey Methods, baseline characteristics and long-term follow-up[J].In J Epidemiol,2011,40(6):1652-1666. [16] 李立明,吕筠,郭彧,等.中国慢性病前瞻性研究:研究方法和调查对象的基线特征[J].中华流行病学杂志,2012,33(3):249-255. [17] 中华医学会糖尿病学分会.中国2型糖尿病防治指南(2010年版)[M].北京:北京大学医学出版社,2011:5. [18] 王昕,吕筠,郭彧,等. 中国慢性病前瞻性研究:10个项目地区成年人群吸烟行为特征差异分析[J]. 中华流行病学杂志,2015,36(11):1200-1204. [19] 吕筠,郭彧,卞铮,等.中国慢性病前瞻性研究:10个项目地区人群饮酒行为特征差异的分析[J]. 中华流行病学杂志,2014,35(8):875-881. [20] AINSWORTH B E,HASKELL W L,HERRMANN S D,et al.2011 Compendium of Physical Activities:a second update of codes and MET values[J].Med Sci Sports Exerc,2011,43(8):1575-1581. [21] DU H D,BENNETT D,LI L M,et al.Physical activity and sedentary leisure time and their associations with BMI,waist circumference,and percentage body fat in 0.5 million adults:the China Kadoorie Biobank study[J]. Am J Clin Nutr,2013,97(3):487-496. [22] 樊萌语,吕筠,郭彧,等.中国慢性病前瞻性研究:10个项目地区成人体力活动和休闲静坐时间特征差异的分析[J].中华流行病学杂志,2015,36(8):779-785. [23] 中华人民共和国卫生部疾病控制司.中国成人超重和肥胖症预防控制指南[M].北京:人民卫生出版社,2006. [24] BRAGG F,TANG K,GUO Y,et al.Associations of general and central adiposity with incident diabetes in Chinese men and women[J].Diabetes care,2018,41(3):494-502. [25] 贺媛,曾强,赵小兰.中国成人肥胖、中心性肥胖与高血压和糖尿病的相关性研究[J].解放军医学杂志,2015,40(10):803-808. [26] HUANG J F,DAI C Y,HWANG S J,et al.Hepatitis C viremia increases the association with type 2 diabetes mellitus in a hepatitis B and C endemic area: an epidemiological link with virological implication[J]. Am J Gastroenterol,2007,102(6):1237-1243. [27] WANG C S,WANG S T,YAO W J,et al.Community-based study of hepatitis C virus infection and type 2 diabetes: an association affected by age and hepatitis severity status[J].Am J Epidemiol,2003,158(12):1154-1160. [28] LAO T T,TSE K Y,CHAN L Y,et al.HBsAg carrier status and the association between gestational diabetes with increased serum ferritin concentration in Chinese women[J].Diabetes Care,2003,26(11):3011-3016. [29] 孙芳芳,匡洪宇.慢性乙型肝炎与糖尿病的研究进展[J].医学综述,2012,18(11):1729-1731. [30] JARCUSKA P,DRAZILOVA S,FEDACKO J,et al.Association between hepatitis B and metabolic syndrome:current state of the art[J].World J Gastroenterol,2016,22(1):155-164.
