Abstract：Objective To evaluate the effect of Metapex for root canal therapy of deciduous teeth.Methods Based on the key words“Metapex paste”and“Root canal therapy of deciduous teeth”, the Chinese database, such as China national knowledge infrastructure，Wanfang database and Weipu database were retrieved. Based on the key words“Metapex”and“deciduous teeth”, the English databases such as PubMed and Medline were retrieved. Collecting random controlled trials about Metapex paste with root canal therapy of deciduous teeth from the beginning of their establishment to August 2017. Do Meta analysis using Rev Man 5.3 software for homogeneous studies, calculating risk ratio（RR）and 95% confidence interval（CI）.Results Twelve studies were included. Meta analysis showed that Metapex was more effective in root canal therapy of deciduous teeth compared with zinc oxide eugenol iodoform paste after 1 year（RR=1.11，95%CI：1.01-1.22）；The clinical effectiveness of Metapex paste was better than calcium hydroxide after 6 months and 1 year（RR6 mouths=1.06，95%CI：1.03-1.09；RR1 year= 0.17，95%CI：1.03-1.10）；There was no obvious difference between Metapex and ZOE after 6 months（RR=1.13，95%CI：1.00-1.27）.Conclusion Metapex paste can improve the success rate on root canal therapy of deciduous teeth , is a more ideal root canal filling material of deciduous teeth .