Abstract：ObjectiveTo evaluate the effects of whole cranberry powder (Pacran�� powder) on immune functions of ICR mice invivo.MethodsFemale ICR mice (18-22 g) were randomly divided into control group and low, medium and high dose groups of whole cranberry powder ( 83,166, and 332 mg/kgbw). Whole cranberry powder was treated with by gavage for 30 days continuously. Control mice were treated with distilled water only. Their immune functions were analyzed, including serum hemolysin analysis, antibody-producing cells (APCs), conA-induced splenic lymphocyte transformation, SRBC-induced delayed type hypersensitivity, natural killer cell activity assay, peritoneal macrophages phagocytosed chicken red blood cells (CRBC), carbon clearance test and thymus or spleen /body weight ratio.ResultsAs compared with the controls, whole cranberry powder treatment increased the number of plague forming cells (PFCs) at 83 mg/kgbw group(P<0.05). There were no statistical difference in the total production of antibodies, the activity of conA-induced splenic lymphocyte transformation, the left-hind voix pedis thickness, NK cytoactivity, the phagocytosis index and ratio of peritoneal macrophages, the carbon clearance ability between the groups treated with different concentrations of whole cranberry powder and the control group (P>0.05).ConclusionWhole cranberry powder can enhance mouse the number of plague forming cells (PFCs).
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