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预防医学  2016, Vol. 28 Issue (10): 973-976    
  论著 本期目录 | 过刊浏览 | 高级检索 |
2型糖尿病合并非酒精性脂肪肝与血清脂联素的相关性研究
范世宏1,2, 毛玉山3, 麦一峰3
1.宁波大学,浙江宁波 315040;
2.宁波市医疗中心李惠利医院;
3.宁波大学医学院附属医院
A study on the association between type 2 diabetes mellitus (T2DM) combined with non-alcoholic fatty liver disease and serum adiponectin
FAN Shi-hong, MAO Yu-shan, MAI Yi-feng
Ningbo University, Ningbo, Zhejiang, 315040, China
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摘要 目的 研究2型糖尿病(T2DM)合并非酒精性脂肪肝(NAFLD)与血清脂联素(APN)的相关性。方法 选取2011年8月—2013年7月宁波大学医学院附属医院收治的76例初发或病史<3年的T2DM患者,按照是否合并NAFLD分为T2DM+NAFLD和T2DM两组,每组各38例,另选30名正常体检者作为对照组(NC组)。测量三组的体质指数(BMI)、血脂、血糖、肝功能、胰岛素抵抗指数(HOMA-IR)和APN等指标水平并进行比较。结果 T2DM+NAFLD组的BMI、三酰甘油(TG)、胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、谷丙转氨酶(ALT)、空腹胰岛素(FINS)及HOMA-IR等指标水平明显高于T2DM组和NC组,APN水平明显低于其他两组(P<0.05);Pearson相关分析显示,APN与BMI、高密度脂蛋白胆固醇(HDL-C)和HOMA-IR呈负相关,与TC、LDL-C和ALT呈正相关(P均<0.05);多元线性回归分析显示HDL-C、HOMA-IR是APN的独立影响因子(P<0.05)。结论 T2DM合并NAFLD患者存在严重的胰岛素抵抗和糖脂代谢紊乱,APN水平是影响NAFLD发生与发展的关键因子。
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范世宏
毛玉山
麦一峰
关键词 2型糖尿病非酒精性脂肪肝胰岛素抵抗血清脂联素相关性研究    
AbstractObjective To explore the association between type 2 diabetes mellitus (T2DM) combined with non-alcoholic fatty liver disease (NAFLD) and serum adiponectin (APN) and its clinical significance. Methods A total of 76 patients who were initially diagnosed with T2DM or had been diagnosed with T2DM for less than three years and admitted to the endocrine department and its outpatient clinic of the Affiliated Hospital of Medical School of Ningbo University from August 2011 to July 2013 were selected as the subjects, and were assigned to group A or B, each consisting of 38 patients, based on the presence or absence of associated NAFLD. Another 30 healthy subjects receiving physical examination were assigned to the control group (NC group). The indicators including body mass index (BMI), blood lipids, blood glucose, liver function, insulin resistance index (HOMA-IR) and serum APN, were measured and compared among the groups. Results In group A , the indicators including BMI, triglyceride (TG), total cholesterol (TC), low density lipoprotein-cholesterol (LDL-C), alanine aminotransferase (ALT), fasting insulin (FINS) and HOMA-IR were significantly higher than those in group B and NC group, and the APN level was significantly lower than that in group B and NC group (P<0.05). Pearson correlation analysis indicated that APN was negatively correlated with BMI, TG, high density lipoprotein-cholesterol(HDL-C), and HOMA-IR, and positively correlated with TC, LDL-C and ALT(P<0.05).Multiple linear regression analysis suggested that HDL-C and HOMA-IR was the independent influencing factors for APN (P<0.05).Conclusion Severe insulin resistance and glucose and lipid metabolic disorders are present in T2DM patients combined with NAFLD, and adiponectin level is of vital significance for the development and progression of NAFLD.
Key wordsType 2 diabetes mellitus    Non-alcoholic fatty liver disease    Insulin resistance index    Serum adiponectin
收稿日期: 2016-02-17      出版日期: 2017-12-20
ZTFLH:  R587.1  
基金资助:宁波成人糖尿病患病率调查研究(2011C50021)
通信作者: 毛玉山,E-mail: zhys 007@tom.comConclusion   
作者简介: 范世宏,硕士在读,主治医师,主要从事内分泌及代谢病临床工作
引用本文:   
范世宏, 毛玉山, 麦一峰. 2型糖尿病合并非酒精性脂肪肝与血清脂联素的相关性研究[J]. 预防医学, 2016, 28(10): 973-976.
FAN Shi-hong, MAO Yu-shan, MAI Yi-feng. A study on the association between type 2 diabetes mellitus (T2DM) combined with non-alcoholic fatty liver disease and serum adiponectin. Preventive Medicine, 2016, 28(10): 973-976.
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http://www.zjyfyxzz.com/CN/      或      http://www.zjyfyxzz.com/CN/Y2016/V28/I10/973
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