Abstract：Objective To investigate the trend in incidence and change in age at onset of malignant tumor in cancer registration areas of Jiangsu Province from 2009 to 2021, so as to provide the evidence for formulating cancer prevention and control strategies and optimizing the allocation of healthcare resources. Methods Incidence data of malignant tumor cases from 2009 to 2021 were collected from the aggregated database of 16 qualified cancer registries of Jiangsu Province. The crude incidence, age-specific incidence, average age at onset, proportion of age-specific incidence, and proportion of incidence in cases aged ≥60 years were calculated by genders and urban/rural areas, and age-standardized using the Segi's world standard population. The trend in incidence of malignant tumor from 2009 to 2021 was evaluated using average annual percent change (AAPC). The trend in average age at onset of malignant tumor from 2009 to 2021 was evaluated using the linear regression model. Results From 2009 to 2021, a total of 703 185 cases of malignant tumor were reported in Jiangsu Province, comprising 400 970 males and 302 215 females. The crude incidence of malignant tumor increased from 268.26/105 in 2009 to 380.97/105 in 2021 (AAPC=2.880%, P<0.05). From 2009 to 2021, the world population-standardized incidence of malignant tumor showed upward trends in the total population, females, and urban and rural areas (AAPC=0.635%, 2.332%, 0.795%, and 0.385%, all P<0.05), while a downward trend was observed in males (AAPC=-0.608%, P<0.05). From 2009 to 2021, the crude incidence of malignant tumor in the groups aged 0-<30 years, 30-<40 years, 40-<50 years, 60-<70 years, and ≥80 years showed upward trends (AAPC=3.160%, 4.462%, 1.295%, 0.569%, and 1.496%, all P<0.05), a downward trend was found in the group aged 50-<60 years (AAPC=-0.860%, P<0.05), while no statistically significant trend was observed in the group aged 70-<80 years (P>0.05). The world population-standardized average age at onset showed downward trends in the total population, females, and urban areas, with average annual decreases of 0.085, 0.223, and 0.136 years, respectively (all P<0.05). Conversely, an upward trend was observed in males, with an average annual increase of 0.081 years (P<0.05). No statistically significant trend was found in rural areas (P>0.05). Compared with 2009, the proportion of malignant tumor incidence cases increased in all age groups between 20-<50 years in 2021. Additionally, the proportion of malignant tumor cases aged over 60 years showed a downward trend from 2009 to 2021 (AAPC=-0.322%, P<0.05). Conclusions From 2009 to 2021, the overall incidence of malignant tumor in registration areas of Jiangsu Province showed an upward trend, with the age at onset tending to become younger. There were differences in the incidence trends across genders and urban/rural areas.
韩仁强, 缪伟刚, 俞浩, 陶然, 周金意. 2009—2021年江苏省肿瘤登记地区恶性肿瘤发病趋势及年龄变化分析[J]. 预防医学, 2025, 37(10): 979-984,990.
HAN Renqiang, MIAO Weigang, YU Hao, TAO Ran, ZHOU Jinyi. Trend in incidence and change in age at onset of malignant tumor in cancer registration areas of Jiangsu Province from 2009 to 2021. Preventive Medicine, 2025, 37(10): 979-984,990.
[1] HAN B F,ZHENG R S,ZENG H M,et al.Cancer incidence and mortality in China,2022[J].J Natl Cancer Cent,2024,4(1):47-53. [2] 陈茹,魏文强.《2022年中国癌症发病和死亡报告》解读[J].中国实用外科杂志,2025,45(2):174-180. CHEN R,WEI W Q.Interpretation of Cancer Incidence and Mortality in China,2022[J].Chin J Pract Surg,2025,45(2):174-180.(in Chinese) [3] 韩仁强,缪伟刚,俞浩,等.2020年江苏省恶性肿瘤发病和死亡现状分析[J].江苏预防医学,2024,35(5):568-574. HAN R Q,MIAO W G,YU H,et al.Incidence and mortality analysis of cancers in Jiangsu Province in 2020[J].Jiangsu J Prev Med,2024,35(5):568-574.(in Chinese) [4] 赫捷,魏文强.2022中国肿瘤登记年报[M].北京:人民卫生出版社,2025. HE J,WEI W Q.China cancer registry annual report 2022[M].Beijing:People's Medical Publishing House,2025.(in Chinese) [5] 郑荣寿,陈万青.癌症发病年龄变化分析[J].中华预防医学杂志,2018,52(6):673-674. ZHENG R S,CHEN W Q.An introduction to the analysis of the age changes for cancer incidence[J].Chin J Prev Med,2018,52(6):673-674.(in Chinese) [6] 郑荣寿,顾秀瑛,李雪婷,等.2000—2014年中国肿瘤登记地区癌症发病趋势及年龄变化分析[J].中华预防医学杂志,2018,52(6):593-600. ZHENG R S,GU X Y,LI X T,et al.Analysis on the trend of cancer incidence and age change in cancer registry areas of China,2000 to 2014[J].Chin J Prev Med,2018,52(6):593-600.(in Chinese) [7] 王少明,郑荣寿,韩冰峰,等.2022年中国人群恶性肿瘤发病与死亡年龄特征分析[J].中国肿瘤,2024,33(3):165-174. WANG S M,ZHENG R S,HAN B F,et al.Age distribution of cancer incidence and mortality in China in 2022[J].China Cancer,2024,33(3):165-174.(in Chinese) [8] 应莉娅,朱洪挺,胡浩,等.2013—2019年永康市恶性肿瘤发病趋势分析[J].预防医学,2023,35(11):970-974. YING L Y,ZHU H T,HU H,et al.Trends in incidence of malignant tumors in Yongkang City from 2013 to 2019[J].China Prev Med J,2023,35(11):970-974.(in Chinese) [9] 胡碧波,傅克本,顾永权.2011—2018年余姚市恶性肿瘤发病趋势[J].预防医学,2023,35(1):44-47,52. HU B B,FU K B,GU Y Q.Trends in incidence of malignant tumors in Yuyao City from 2011 to 2018[J].China Prev Med J,2023,35(1):44-47,52.(in Chinese) [10] 韩颖颖,蔡波,林玲,等.2009—2019年江苏省肿瘤登记地区女性乳腺癌发病趋势及年龄变化分析[J].中国肿瘤,2024,33(12):970-976. HAN Y Y,CAI B,LIN L,et al.Trends of incidence and age at onset of female breast cancer in Jiangsu cancer registration areas from 2009 to 2019[J].China Cancer,2024,33(12):970-976.(in Chinese) [11] 杨志杰,王璐,钱云,等.2009—2019年江苏省肿瘤登记地区甲状腺癌发病趋势和年龄变化特征分析[J].中国肿瘤,2024,33(12):991-998. YANG Z J,WANG L,QIAN Y,et al.Trends of incidence and diagnostic age of thyroid cancer in cancer registration areas of Jiangsu Province from 2009 to 2019[J].China Cancer,2024,33(12):991-998.(in Chinese) [12] 邱玉保,于蕾,陈蕾,等.2009—2019年江苏省肿瘤登记地区胃癌发病趋势及年龄特征分析[J].中国肿瘤,2024,33(12):961-969. QIU Y B,YU L,CHEN L,et al.Trends of incidence and age characteristics of gastric cancer in cancer registration areas of Jiangsu Province from 2009 to 2019[J].China Cancer,2024,33(12):961-969.(in Chinese) [13] MIAO W G,FENG Y Y,JIANG B J,et al.Projections of esophageal cancer incidence trend in Jiangsu Province,China:a Bayesian modeling study[J].J Natl Cancer Cent,2024,5(2):149-155. [14] 姜碧佳,韩仁强,缪伟刚,等.2009—2019年江苏省肿瘤登记地区肝癌发病趋势及年龄变化分析[J/OL].中国肿瘤,2025[2025-09-23].https://link.cnki.net/urlid/11.2859.R.20250513.1713.008. JIANG B J,HAN R Q,MIAO W G,et al.Trends of incidence and age composition of liver cancer in cancer registration areas of Jiangsu Province from2009 to 2019[J/OL].China Cancer,2025[2025-09-23].https://link.cnki.net/urlid/11.2859.R.20250513.1713.008.(in Chinese) [15] HE F F,WANG S M,ZHENG R S,et al.Trends of gastric cancer burdens attributable to risk factors in China from 2000 to 2050[J].Lancet Reg Health West Pac,2024,44:1-14. [16] ZHANG M,YANG L,WANG L M,et al.Trends in smoking prevalence in urban and rural China,2007 to 2018:findings from 5 consecutive nationally representative cross-sectional surveys[J].PLoS Med,2022,19(8):1-21. [17] XIE L,LIU G W,LIU Y N,et al.Prevalence of Helicobacter pylori infection in China from 2014-2023:a systematic review and meta-analysis[J].World J Gastroenterol,2024,30(43):4636-4656. [18] YUAN S,XIE S H.Urban-rural disparity in cancer incidence in China,2008-2012:a cross-sectional analysis of data from 36 cancer registers[J].BMJ Open,2021,11(4):1-8. [19] 许昕,赵媛,夏四友,等.中国分县城乡人口老龄化时空差异与机理[J].经济地理,2020,40(4):164-174. XU X,ZHAO Y,XIA S Y,et al.Spatial and temporal characteristics and mechanism of urban and rural population ageing in China[J].Econ Geogr,2020,40(4):164-174.(in Chinese) [20] ZHAO J H,XU L Y,SUN J,et al.Global trends in incidence,death,burden and risk factors of early-onset cancer from 1990 to 2019[J].BMJ Oncol,2023,2(1):1-12.
