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预防医学  2023, Vol. 35 Issue (3): 215-217,223    DOI: 10.19485/j.cnki.issn2096-5087.2023.03.007
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肝X受体在阿尔茨海默病发病机制中的研究进展
刘贺琼1,2, 马超颖1,2, 郭会彩1,2 综述, 王磊3, 刘诣1,2 审校
1.河北医科大学公共卫生学院,河北 石家庄 050017;
2.河北省环境与人群健康重点实验室,河北 石家庄 050017;
3.河北医科大学,河北 石家庄 050017
The role of LXRs in the pathogenesis of Alzheimer's disease: a review
LIU Heqiong1,2, MA Chaoying1,2, GUO Huicai1,2, WANG Lei3, LIU Yi1,2
1. School of Public Health, Hebei Medical University, Shijiazhuang, Hebei 050017, China;
2. Hebei Key Laboratory of Environment and Human Health, Shijiazhuang, Hebei 050017, China;
3. Hebei Medical University, Shijiazhuang, Hebei 050017, China
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摘要 阿尔茨海默病(AD)是一种以β淀粉样蛋白沉积为特征的神经退行性疾病。肝X受体(LXRs)是核受体转录因子超家族的一员,在大脑中广泛表达,可能参与AD的发生发展。本文检索2010—2022年LXRs与AD发病相关的国内外研究文献,围绕LXRs在AD发病机制中参与调控胆固醇代谢、炎症反应和突触形成的研究进展进行综述,为AD防制提供理论依据。
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刘贺琼
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郭会彩
王磊
刘诣
关键词 肝X受体阿尔茨海默病胆固醇代谢炎症反应突触形成    
Abstract:Alzheimer's disease (AD) is a neurodegenerative disease characterized by deposition of β-amyloid (Aβ). Liver X receptors (LXRs), a member of the nuclear receptor transcription factor superfamily, are widely expressed in brain, which may be involved in the development and progression of AD. Based on the international and national publications pertaining to the association between LXRs and AD from 2010 to 2022, this review summarizes the advances on the involvement of LXRs in the regulation of cholesterol metabolism, inflammatory response and synapse formation in the pathogenesis of AD was reviewed, so as to provide insights into the prevention and treatment of AD.
Key wordsliver X receptor    Alzheimer's disease    cholesterol metabolism    inflammatory response    synapse formation
收稿日期: 2022-09-01      修回日期: 2023-01-17      出版日期: 2023-03-10
中图分类号:  R749.16  
基金资助:国家自然科学基金(82073681); 河北省自然科学基金(B2020206008,H2020206584); 河北省省级科技计划资助(19274801D); 河北省教育厅重点项目(ZD2019044)
作者简介: 刘贺琼,硕士研究生在读
通信作者: 刘诣,E-mail:liuyi78@hebmu.edu.cn   
引用本文:   
刘贺琼, 马超颖, 郭会彩, 王磊, 刘诣. 肝X受体在阿尔茨海默病发病机制中的研究进展[J]. 预防医学, 2023, 35(3): 215-217,223.
LIU Heqiong, MA Chaoying, GUO Huicai, WANG Lei, LIU Yi. The role of LXRs in the pathogenesis of Alzheimer's disease: a review. Preventive Medicine, 2023, 35(3): 215-217,223.
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http://www.zjyfyxzz.com/CN/10.19485/j.cnki.issn2096-5087.2023.03.007      或      http://www.zjyfyxzz.com/CN/Y2023/V35/I3/215
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