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预防医学  2022, Vol. 34 Issue (8): 799-802    DOI: 10.19485/j.cnki.issn2096-5087.2022.08.009
  综述 本期目录 | 过刊浏览 | 高级检索 |
双酚类化合物暴露及健康影响研究进展
胡炀1, 王晓峰2, 陈志健2, 徐沛维2 综述, 楼晓明2 审校
1.宁波大学医学院,浙江 宁波 315000;
2.浙江省疾病预防控制中心,浙江 杭州 310051
Exposure to and health effects of bisphenols: a review
HU Yang1, WANG Xiaofeng2, CHEN Zhijian2, XU Peiwei2, LOU Xiaoming2
1. School of Medicine, Ningbo University, Ningbo, Zhejiang 315000, China;
2. Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou, Zhejiang 310051, China
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摘要 双酚类化合物(BPs)主要用于生产制造聚碳酸酯和环氧树脂,是自然环境中常见的内分泌干扰物。人体主要通过摄入和皮肤接触途径暴露,现有研究在人的尿液、血清和乳汁中检出BPs,孕妇和儿童的暴露水平较高。本文查阅国内外2009年以来关于BPs的研究文献,对BPs在人群尿液、血清和乳汁的暴露情况,以及在神经内分泌功能、氧化应激和表观遗传学等方面的损伤机制进行综述,为降低BPs暴露和健康风险提供依据。
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胡炀
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陈志健
徐沛维
楼晓明
关键词 双酚类化合物内分泌干扰物人群暴露健康影响    
Abstract:Bisphenols (BPs), which are mainly used in the production of polycarbonates and epoxy resins, are common endocrine disruptors (EDCs) in natural environments. Human mainly exposes to BPs via ingestion and skin. Previous studies have deteted BPs in human urine, serum, and milk samples, and children and pregnant women have a high level of exposure to to BPs. Based on international and national publications pertaining to BPs since 2009, this review describes the exposure to BPs in human urine, serum, and milk and summarizes neuroendocrine dysfunctions, oxidative stress injury and epigenetics changes caused by BPs, so as to provide insights into reducing the exposure to and health risk of BPs.
Key wordsbisphenols    endocrine disruptor    human exposure    health effect
收稿日期: 2022-02-21      修回日期: 2022-06-13      出版日期: 2022-08-10
中图分类号:  R114  
作者简介: 胡炀,硕士研究生在读
通信作者: 楼晓明,E-mail:xmlou@cdc.zj.cn   
引用本文:   
胡炀, 王晓峰, 陈志健, 徐沛维, 楼晓明. 双酚类化合物暴露及健康影响研究进展[J]. 预防医学, 2022, 34(8): 799-802.
HU Yang, WANG Xiaofeng, CHEN Zhijian, XU Peiwei, LOU Xiaoming. Exposure to and health effects of bisphenols: a review. Preventive Medicine, 2022, 34(8): 799-802.
链接本文:  
http://www.zjyfyxzz.com/CN/10.19485/j.cnki.issn2096-5087.2022.08.009      或      http://www.zjyfyxzz.com/CN/Y2022/V34/I8/799
[1] MURATA M,KANG J H.Bisphenol A(BPA)and cell signaling pathways[J].Biotechnol Adv,2018,36(1):311-327.
[2] CHEN D,KANNAN K,TAN H,et al.Bisphenol analogues other than BPA:environmental occurrence,human exposure,and toxicity-a review[J].Environ Sci Technol,2016,50(11):5438-5453.
[3] YAMAZAKI E,YAMASHITA N,TANIYASU S,et al.Bisphenol A and other bisphenol analogues including BPS and BPF in surface water samples from Japan,China,Korea and India[J].Ecotoxicol Environ Saf,2015,122:565-572.
[4] RUDEL R A,CAMANN D E,SPENGLER J D,et al.Phthalates,alkylphenols,pesticides,polybrominated diphenyl ethers,and other endocrine-disrupting compounds in indoor air and dust[J].Environ Sci Technol,2003,37(20):4543-4553.
[5] LARSSON K,LINDH C H,JÖNSSON B A,et al.Phthalates,non-phthalate plasticizers and bisphenols in Swedish preschool dust in relation to children's exposure[J].Environ Int,2017,102:114-124.
[6] LIAO C,LIU F,GUO Y,et al.Occurrence of eight bisphenol analogues in indoor dust from the United States and several Asian countries:implications for human exposure[J].Environ Sci Technol,2012,46(16):9138-9145.
[7] CHAKRABORTY P,SAMPATH S,MUKHOPADHYAY M,et al.Baseline investigation on plasticizers,bisphenol A,polycyclic aromatic hydrocarbons and heavy metals in the surface soil of the informal electronic waste recycling workshops and nearby open dumpsites in Indian metropolitan cities[J].Environ Pollut,2019,248:1036-1045.
[8] XU Y,HU A,LI Y,et al.Determination and occurrence of bisphenol A and thirteen structural analogs in soil [J/OL].Chemosphere,2021,277[2022-06-13].https://doi.org/10.1016/j.chemosphere.2021.130232.
[9] CALAFAT A M,WEUVE J,YE X,et al.Exposure to bisphenol A and other phenols in neonatal intensive care unit premature infants[J].Environ Health Perspect,2009,117(4):639-644.
[10] HE Y,MIAO M,HERRINTON L J,et al.Bisphenol A levels in blood and urine in a Chinese population and the personal factors affecting the levels[J].Environ Res,2009,109(5):629-633.
[11] WANG X,WANG X,CHEN Q,et al.Urinary bisphenol A concentration and gestational diabetes mellitus in Chinese women[J].Epidemiology,2017,28(Suppl.1):S41-S47.
[12] LEE J,CHOI K,PARK J,et al.Bisphenol A distribution in serum,urine,placenta,breast milk,and umbilical cord serum in a birth panel of mother-neonate pairs[J].Sci Total Environ,2018,626:1494-1501.
[13] LIU M,JIA S,DONG T,et al.The occurrence of bisphenol plasticizers in paired dust and urine samples and its association with oxidative stress[J].Chemosphere,2019,216:472-478.
[14] PHILIPS E M,SANTOS S,STEEGERS E A P,et al.Maternal bisphenol and phthalate urine concentrations and weight gain during pregnancy [J/OL].Environ Int,2020,135[2022-06-13].https://doi.org/10.1016/j.envint.2019.105342.
[15] KATARIA A,LEVINE D,WERTENTEIL S,et al.Exposure to bisphenols and phthalates and association with oxidant stress,insulin resistance,and endothelial dysfunction in children[J].Pediatr Res,2017,81(6):857-864.
[16] SONG S,DUAN Y,ZHANG T,et al.Serum concentrations of bisphenol A and its alternatives in elderly population living around e-waste recycling facilities in China:associations with fasting blood glucose[J].Ecotoxicol Environ Saf,2019,169:822-828.
[17] ZHANG B,HE Y,ZHU H,et al.Concentrations of bisphenol A and its alternatives in paired maternal-fetal urine,serum and amniotic fluid from an e-waste dismantling area in China [J/OL].Environ Int,2020,136[2022-06-13].https://doi.org/10.1016/j.envint.2019.105407.
[18] LIU J,LI J,WU Y,et al.Bisphenol A metabolites and bisphenol S in paired maternal and cord serum[J].Environ Sci Technol,2017,51(4):2456-2463.
[19] KIM S,LEE J,PARK J,et al.Concentrations of phthalate metabolites in breast milk in Korea:estimating exposure to phthalates and potential risks among breast-fed infants[J].Sci Total Environ,2015,508:13-19.
[20] ZIMMERS S M,BROWNE E P,O'KEEFE P W,et al.Determination of free bisphenol A(BPA)concentrations in breast milk of U.S.women using a sensitive LC/MS/MS method[J].Chemosphere,2014,104:237-243.
[21] NIU Y,WANG B,YANG R,et al.Bisphenol analogues and their chlorinated derivatives in breast milk in China:occurrence and exposure assessment[J].J Agric Food Chem,2021,69(4):1391-1397.
[22] JIN H,XIE J,MAO L,et al.Bisphenol analogue concentrations in human breast milk and their associations with postnatal infant growth [J/OL].Environ Pollut,2020,259[2022-06-13].https://doi.org/10.1016/j.envpol.2019.113779.
[23] MHAOUTY-KODJA S,BELZUNCES L P,CANIVENC M C,et al.Impairment of learning and memory performances induced by BPA:evidences from the literature of a MoA mediated through an ED[J].Mol Cell Endocrinol,2018,475:54-73.
[24] WISNIEWSKI P,ROMANO R M,KIZYS M M,et al.Adult exposure to bisphenol A(BPA)in Wistar rats reduces sperm quality with disruption of the hypothalamic-pituitary-testicular axis[J].Toxicology,2015,329:1-9.
[25] DE FILIPPIS E,LI T,ROSEN E D.Exposure of adipocytes to bisphenol-A in vitro interferes with insulin action without enhancing adipogenesis [J/OL].PLoS One,2018,13(8)[2022-06-13].https://doi.org/10.1371/journal.pone.0201122.
[26] XIN F,FISCHER E,KRAPP C,et al.Mice exposed to bisphenol A exhibit depressive-like behavior with neurotransmitter and neuroactive steroid dysfunction[J].Horm Behav,2018,102:93-104.
[27] WEHBE Z,NASSER S A,EL-YAZBI A,et al.Estrogen and bisphenol A in hypertension [J/OL].Curr Hypertens Rep,2020,22(3)[2022-06-13].https://doi.org/10.1007/s11906-020-1022-z.
[28] PTAK A,GREGORASZCZUK E L.Bisphenol A induces leptin receptor expression,creating more binding sites for leptin,and activates the JAK/Stat,MAPK/ERK and PI3K/Akt signalling pathways in human ovarian cancer cell[J].Toxicol Lett,2012,210(3):332-337.
[29] XU J,HUANG G,GUO T L.Developmental bisphenol A exposure modulates immune-related diseases [J/OL].Toxics,2016,4(4)[2022-06-13].https://doi.org/10.3390/toxics4040023
[30] XU J,HUANG G,NAGY T,et al.Sex-dependent effects of bisphenol A on type 1 diabetes development in non-obese diabetic(NOD)mice[J].Arch Toxicol,2019,93(4):997-1008.
[31] OLUKOLE S G,LANIPEKUN D O,OLA-DAVIES E O,et al.Melatonin attenuates bisphenol A-induced toxicity of the adrenal gland of Wistar rats[J].Environ Sci Pollut Res Int,2019,26(6):5971-5982.
[32] ABEDELHAFFEZ A S,EL-AZIZ E A A,AZIZ M A A,et al.Lung injury induced by bisphenol A:a food contaminant,is ameliorated by selenium supplementation[J].Pathophysiology,2017,24(2):81-89.
[33] ZBUCKA-KRETOWSKA M,ZBUCKI R,PARFIENIUK E,et al.Evaluation of bisphenol A influence on endocannabinoid system in pregnant women[J].Chemosphere,2018,203:387-392.
[34] MA L,HU J,LI J,et al.Bisphenol A promotes hyperuricemia via activating xanthine oxidase[J].FASEB J,2018,32(2):1007-1016.
[35] HERZ C,TRAN H T T,SCHLOTZ N,et al.Low-dose levels of bisphenol A inhibit telomerase via ER/GPR30-ERK signalling,impair DNA integrity and reduce cell proliferation in primary PBMC [J/OL].Sci Rep,2017,7(1)[2022-06-13].https://doi.org/10.1038/s41598-017-15978-2.
[36] RADWAN M,WIELGOMAS B,DZIEWIRSKA E,et al.Urinary bisphenol A levels and male fertility[J].Am J Mens Health,2018,12(6):2144-2151.
[37] YE Y,TANG Y,XIONG Y,et al.Bisphenol A exposure alters placentation and causes preeclampsia-like features in pregnant mice involved in reprogramming of DNA methylation of WNT2[J].FASEB J,2019,33(2):2732-2742.
[38] LI X,XIE W,XIE C,et al.Curcumin modulates miR-19/PTEN/AKT/p53 axis to suppress bisphenol A-induced MCF-7 breast cancer cell proliferation[J].Phytother Res,2014,28(10):1553-1560.
[39] CHEONG A,ZHANG X,CHEUNG Y Y,et al.DNA methylome changes by estradiol benzoate and bisphenol A links early-life environmental exposures to prostate cancer risk[J].Epigenetics,2016,11(9):674-689.
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