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预防医学  2022, Vol. 34 Issue (7): 665-671    DOI: 10.19485/j.cnki.issn2096-5087.2022.07.004
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飞行人员高脂血症与肠道菌群分布研究
王冬1, 陈基快2, 蔡文杰1, 陈岳涛1, 蒋春燕3, 郁小红1
1.空军杭州特勤疗养中心疗养三区康复理疗科,浙江 杭州 310004;
2.海军军医大学,上海 200433;
3.中国人民解放军第903医院,浙江 杭州 310013
Hyperlipidemia and intestinal microflora distributions among flying personnel
WANG Dong1, CHEN Jikuai2, CAI Wenjie1, CHEN Yuetao1, JIANG Chunyan3, YU Xiaohong1
1. Department of Rehabilitative Physioltherapy of the Third Sanitarium Area, Air Force Health Care Center Special Services, Hangzhou, Zhejiang 310004, China;
2. Naval Medical University, Shanghai 200433, China;
3. No.903 Hospital of the PLA, Hangzhou, Zhejiang 310013, China
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摘要 目的 探讨患高脂血症飞行人员的肠道菌群特征,为预防飞行人员高脂血症提供依据。方法 选择2020年10月—2021年2月在某疗养中心健康体检诊断为高脂血症的飞行人员纳入高脂血症组,同期健康体检血脂正常的飞行人员纳入对照组;收集两组研究对象的年龄、家族史、体格检查和临床生化检测资料。采集粪便标本,对肠道菌群进行测序和生物学信息分析,比较肠道菌群多样性和菌属丰度差异,采用LEfSe分析法筛选关键微生物。结果 纳入高脂血症组29例,对照组25人,均为男性,年龄MQR)分别为34(12)岁和30(12)岁。两组研究对象年龄、飞行时间、吸烟、代谢性疾病家族史和腰围等比较,差异均无统计学意义(P>0.05)。高脂血症组肠道菌群α多样性指数Shannon低于对照组(Z=4.370,P=0.026)。β多样性分析显示,两组肠道菌群的总体结构存在差异,分别聚集为2个类群。LEfSe分析显示,高脂血症组的关键菌属为草螺菌属、奇异菌属和埃格特菌属;对照组的关键菌属为直肠真杆菌属、戴阿利斯特杆菌属、真杆菌属组、拟普雷沃菌属和未分类拟杆菌目。结论 患高脂血症飞行人员肠道菌群物种多样性、菌属相对丰度较血脂正常飞行人员降低;草螺菌属、奇异菌属和埃格特菌属可能是患高脂血症飞行人员的关键菌属。
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王冬
陈基快
蔡文杰
陈岳涛
蒋春燕
郁小红
关键词 飞行人员肠道菌群高脂血症    
AbstractObjective To investigate the characteristics of intestinal microflora among flying personnel with hyperlipidemia, so as to provide insights into prevention of hyperlipidemia among flying personnel. Methods Flying personnel diagnosed with hyperlipidemia in a sanatiorium from October 2020 to February 2021 were included in the hyperlipidemia group, while flying personnel with normal blood lipids during the same period served as controls. Subjects' age, family history, physical examinations and blood testing results were collected from both groups. Fecal samples were collected, and intestinal microflora was sequenced followed by bioinformatics analysis. The diversity and abundance of intestinal microflora were compared, and the key bacteria were screened using LEfSe analysis. Results There were 29 subjects in the hyperlipidemia group with a median age (interquartile range) of 34 (12) years and 25 subjects in the control group with a median age (interquartile range) of 30 (12) years, and all subjects were men. There were no significant differences between the two groups in terms of age, flight duration, smoking, family history of metabolic diseases and waist circumference (P>0.05). The Shannon diversity index of intestinal microflora was lower in the hyperlipidemia group than in the control group (Z=4.370, P=0.026), and there was a significant difference in the overall structure of intestinal flora between the two groups, which were clustered into two groups. LEfSe analysis identified Herbaspirillum, Atopobium and Eggerthella as key microorganisms in the hyperlipidemia group, and Agathobacter, Dialister, norank_Eubacterium_coprostanoligenes_group, Alloprevotella and unclassified Bacteroidales as key microorganisms in the control group. Conclusions The species diversity and relative abundance of intestinal microflora are lower in flying personnel with hyperlipidemia than in those with normal blood lipids. Herbaspirillum, Atopobium and Eggerthella may be the key bacteria contributing to hyperlipidemia among flying personnel.
Key wordsflying personnel    intestinal microflora    hyperlipidemia
收稿日期: 2022-03-21      修回日期: 2022-05-23      出版日期: 2022-07-10
中图分类号:  R58  
基金资助:杭州市科技攻关项目课题(20200133X04)
通信作者: 郁小红,E-mail:13858031195@163.com   
作者简介: 王冬,硕士,副主任医师,主要从事特勤人员常见疾病诊疗工作
引用本文:   
王冬, 陈基快, 蔡文杰, 陈岳涛, 蒋春燕, 郁小红. 飞行人员高脂血症与肠道菌群分布研究[J]. 预防医学, 2022, 34(7): 665-671.
WANG Dong, CHEN Jikuai, CAI Wenjie, CHEN Yuetao, JIANG Chunyan, YU Xiaohong. Hyperlipidemia and intestinal microflora distributions among flying personnel. Preventive Medicine, 2022, 34(7): 665-671.
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http://www.zjyfyxzz.com/CN/10.19485/j.cnki.issn2096-5087.2022.07.004      或      http://www.zjyfyxzz.com/CN/Y2022/V34/I7/665
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