Abstract：Objective To observe the concentration of the anti-HBs of children boosted with hepatitis A and B combined vaccine for 3 dosages, and to provide the basis for the implementation of hepatitis B booster immunization. Methods In September 2009 in Yuhuan by employing the cluster sampling method, 123 children, ranging from 6 to 9 years old,who had completed the basic immunization by 0-1-6 procedure without hepatitis B vaccine boosted and without anti-HBs were selected. In the year of 2011（after 1 year of inoculation）and 2015（5 years after inoculation）,the venous blood samples were collected to determine the concentration of anti-HBs. Results Boosted with hepatitis A and B combined vaccine for 3 times, the anti-HBs of 102 subjects was tested in the next year, of which the anti-HBs of 82 subjects was detected again in the later 5 years. The results suggested that the positive rates of antibody enhanced were 92.16% after 1 year and 78.05% after 5 years, respectively. The average concentration of anti-HBs of these 82 subjects was 2.95 mIU/mL before inoculation, 141.76 mIU/mL one year later and 72.13 mIU/mL 5 years later and there was statistically significant difference among them（P<0.05）. The difference was not statistically significant between subjects with different years of birth（P>0.05）. Moreover,the interaction was existed between the year of blood detection and year of birth （P<0.05）. Conclusion To children aged 6-9 years old whose anti-HBs were negative after the primary immunization of hepatitis B, booster immunization with 3 dosages of hepatitis A and B combined vaccine shows good immune effect against hepatitis B virus.
刘灿磊, 姚军, 施海云, 尚建斌, 陈丹, 殷银香, 罗萍. 儿童接种甲乙型肝炎联合疫苗对乙肝加强免疫的效果评价[J]. 预防医学, 2017, 29(11): 1086-1088,1093.
LIU Can-lei, YAO Jun, SHI Hai-yun, SHANG Jian-bin, CHEN Dan, YIN Yin-xiang, LUO Ping. The immune effects of hepatitis B on children boosted with hepatitis A and B combined vaccine. Preventive Medicine, 2017, 29(11): 1086-1088,1093.
