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预防医学  2019, Vol. 31 Issue (1): 42-46    DOI: 10.19485/j.cnki.issn2096-5087.2019.01.010
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晚发抑郁症患者抑郁程度与神经认知功能的相关性研究
程韬, 应翔, 张俊英, 吕跃忠
金华市第二医院精神科,浙江 金华 321016
Correlation analysis of depression severity and neurocognitive function in patients with late-onset depression
CHENG Tao, YING Xiang, ZHANG Jun-ying, LYU Yue-zhong
Department of Psychiatry,Jinhua Second Hospital,Jinhua,Zhejiang 321016,China
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摘要 目的 探究晚发抑郁症患者抑郁严重程度与神经认知功能的相关性。方法 选取2015年2月—2017年12月金华市第二医院收治的晚发抑郁症患者,根据汉密尔顿抑郁量表(HAMD-17)评估抑郁严重程度,并分为轻度、中度和重度组,同期≥60岁健康体检人员纳入对照组,采用威斯康星卡片分类测验(WCST)、词语流畅性测验(VFT)和Stroop字色干扰测验评估神经认知功能,比较4组研究对象的3项测验结果差异,分析HAMD-17评分与3项测验结果的相关性。结果 轻度、中度、重度和对照组分别纳入32、28、35和35人。与对照组比较,轻度、中度和重度组患者的WCST错误应答数、持续性应答数、持续性错误数均增加,概念化水平应答百分数减少(均P<0.05);轻度、中度和重度组3组比较,错误应答数、持续性应答数、持续性错误数和持续性错误百分数均依严重程度递增,概念化水平应答百分数依严重程度递减(均P<0.05)。重度组患者的Stroop测验一致组正确数、VFT正确数均少于对照组、轻度组和中度组(均P<0.05),而轻度组和中度组患者与对照组差异均无统计学意义(P>0.05)。HAMD-17量表评分与Stroop测验一致组正确数(r=-0.448,P<0.001)、VFT正确数(r=-0.401,P<0.001)呈负相关,与WCST持续应答数呈正相关(r=0.784,P<0.001)。结论 晚发抑郁症患者抑郁严重程度加重,其神经认知功能损伤也随之加重。
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程韬
应翔
张俊英
吕跃忠
关键词 晚发抑郁症神经认知功能老年人    
AbstractObjective To explore the correlation between depression severity and neurocognitive function in patients with late-onset depression .Methods The patients with late-onset depression treated in Jinhua Second hospital from February 2015 to December 2017 were assigned into the mild,moderate and severe groups according to the severity of depression assessed by the Hamilton Depression Scale-17(HAMD-17). At the same time,some healthy persons were selected as the control group. Wisconsin Card Sorting Test(WCST),Verbal Fluency Test(VFT)and Stroop Test were carried out,and the scores of these tests were compared in the four groups. The correlations of WCST, VFT, Stroop Test and HAMD-17 scores were analyzed .Results There were 32,28,35 and 35 subjects involved in the mild,moderate,severe and control group,respectively. The subjects of the mild group,moderate group and severe group had more total errors,perseverative responses and perseverative errors than the control group,and less percent conceptual level responses than the control group (all P<0.05). The total errors,perseverative responses,perseverative errors and percent perseverative errors increased and the percent conceptual level responses decreased gradually with the severity of depression(all P<0.05). The correct numbers of Stroop-consistent group and VFT in the severe group were less than those in the control,mild and moderate group(all P<0.05),which was significantly different between the mild,moderate and control group (P>0.05). The HAMD-17 scores were negatively correlated with the correct numbers of Stroop congruent group(r=-0.448,P<0.001)and VFT(r=-0.401,P<0.001),and were positively correlated with perseverative responses in the WCST(r=0.784,P<0.001) .Conclusion The neurocognitive impairment in patients with late-onset depression aggravated with the severity of depression.
Key wordsLate-onset depression    Neurocognitive function    Elderly population
收稿日期: 2018-08-15      出版日期: 2019-01-03
ZTFLH:  R749.41  
通信作者: 程韬,E-mail:kkzjmm@163.com   
作者简介: 程韬,本科,副主任医师,主要从事临床精神病诊治工作
引用本文:   
程韬, 应翔, 张俊英, 吕跃忠. 晚发抑郁症患者抑郁程度与神经认知功能的相关性研究[J]. 预防医学, 2019, 31(1): 42-46.
CHENG Tao, YING Xiang, ZHANG Jun-ying, LYU Yue-zhong. Correlation analysis of depression severity and neurocognitive function in patients with late-onset depression. Preventive Medicine, 2019, 31(1): 42-46.
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