Abstract:Objective To investigate the association between dietary selenium intake and hypertension among Zhejiang residents .Methods By multistage stratified random sampling method,four urban sites and two rural sites out of Zhejiang Province,four communities or villages out of each site,then 20 households out of each community or village were selected,and all the family members of the selected households were recruited as participants. The questionnaire of Chinese Health and Nutrition Survey was used to collect information about socio-demographic characteristics and dietary selenium intake. The blood pressure,blood lipid and other data were collected via physical examination. A multivariate logistic regression model was used to analyze the relationship between dietary selenium intake and hypertension .Results A total of 1 222 participants with complete dietary selenium intake data were included for analysis. The number(%)of participants with selenium intake higher than the level of estimated average requirement(EAR),between the levels of EAR and recommanded nutrient intake (RNI),between the levels of RNI and upper intake(UI)and higher than the level of UI were 729 (59.66%),151(12.36%),341(27.91%)and 1(0.01%),respectively. There were 283 (30.53%)patients with hypertension out of 927 participants examined. The mean amount of selenium intake in patients with hypertention was(43.06±20.96)μg/d,which was significantly lower than(51.56±30.06) μg/d in non-hypertention participants(P<0.05). After adjusting for age,body mass index,total cholesterol,triglyceride and diabetes mellitus in the multivariate logistic regression model,dietary selenium intake significantly reduced the risk of hypertension(OR=0.985,95%CI:0.978-0.993) .Conclusion About 60% of residents in Zhejiang Province had lower dietary selenium intake than estimated average requirement. Higher selenium intake was associated with lower risk of hypertension.
LI Q,LIU M,HOU J,et al.The prevalence of keshan disease in China[J]. International Journal of Cardiology,2013,168(2):1121-1126.
[4]
LIU H,YU F,SHAO W,et al.Associations between selenium content in hair and kashin-beck disease/keshan disease in children in northwestern China:a prospective cohort study[J]. Biological Trace Element Research,2018,184(1):16-23.
[5]
GHARIPOUR M,SADEGHI M,BEHMANESH M,et al.Selenium homeostasis and clustering of cardiovascular risk factors:a systematic review[J]. Acta bio-medica:Atenei Parmensis,2017,88(3):263-270.
[6]
BALTACI A K,MOGULKOC R,AKIL M,et al.Review- selenium-its metabolism and relation to exercise[J]. Pakistan Journal of Pharmaceutical Sciences,2016,29(5):1719-1725.
[7]
NAREGAL G V,DEVARANAVADAGI B B,PATIL S G,et al. Elevation of oxidative stress and decline in endogenous antioxidant defense in elderly individuals with hypertension[J]. Journal of Clinical and Diagnostic Research,2017,11(7):BC09-BC12.
[8]
KURUPPU D,HENDRIE H C,YANG L,et al.Selenium levels and hypertension:a systematic review of the literature[J]. Public Health Nutrition,2014,17(6):1342-1352.
[9]
ARNAUD J,AKBARALY T N,HININGER I,et al.Factors associated with longitudinal plasma selenium decline in the elderly:the EVA Study[J]. Journal of Nutritional Biochemistry,2007,18(7):482-487.
[10]
ZHANG B,ZHAI F,DU S,et al.The China health and nutrition survey,1989-2011[J]. Obesity Reviews,2013,15(S1):2-7.
SALONEN J T,ALFTHAN G,HUTTUNEN J K,et al.Association between cardiovascular death and myocardial infarction and serum selenium in a matched-pair longitudinal study[J]. Lancet,1982,320(8291):175-179.
[18]
MIHAILOVIA M B,AVRAMOVIA D M,JOVANOVIA I B,et al.Blood and plasma selenium levels and gsh-px activities in patients with arterial hypertension and chronic heart disease[J]. J Environ Pathol Toxicol Oncol,1998,17(3/4):285-289.
COMBS G F.Biomarkers of selenium status[J]. Nutrients,2015, 7(4):2209-2236.
[21]
HE M J,ZHANG S Q,MU W,et al.Selenium in infant formula milk[J]. Asia Pacific Journal of Clinical Nutrition,2018,27(2):284-292.
[22]
OGAWA-WONG A N,BERRY M J,SEALE L A. Selenium and metabolic disorders:an emphasis on type 2 diabetes risk[J]. Nutrients,2016,8(2):80.
[23]
GROTTO D,CARNEIRO M F H,CASTRO M M D,et al. Long-term excessive selenium supplementation induces hypertension in rats[J]. Biological Trace Element Research,2017,182(1):1-8.