Abstract:Objective To learn the HIV infection status and related factors among spouses of HIV/AIDS. Methods We recruited HIV/AIDS cases diagnosed between January 2000 and August 2016 in Lu'an and their spouses to collect the demographic information and sexual behavior characteristics. For HIV sero-accordant spouses,we analyzed influencing factors for HIV infection by logistic regression model; while for HIV sero-discordant spouses,we followed up until December 31,2016 and detected their HIV antibody periodically. Results The HIV infection rate of spouses was 20.35%(47/231). Forty-five of the spouses had been infected with HIV before our investigation,with a infection rate of 19.48%(45/231). Two of the spouses developed positive HIV antibody during the follow-up with a positive conversion rate of 0.39/100 person-years. Multivariate logistic regression analysis indicated that high frequency of sexual contacts before confirmed as HIV positive(OR≥1/week= 6.268,95%CI:2.313-16.985;OR1/half a month=3.760,95%CI:1.268-11.150)and diagnosis during 2011-2014(OR=3.079,95%CI:1.209-7.841)were the risk factors for HIV transmission between couples; under the age of 25(OR=0.042,95%CI:0.004-0.467)when confirmed as HIV positive and early viral load<300 copies/mL(OR=0.115,95%CI:0.045-0.295)were protective factors. Conclusion HIV transmission of spouses is associated with frequency of sexual contacts,time of diagnosis,age when confirmed as HIV positive and early viral load.