Abstract：Objective To evaluate the effects of a multidisciplinary weight management intervention, so as to provide a reference for the formulation of overweight and obesity intervention measures. Methods From April to September 2025, overweight and obese residents aged 18-60 years who participated in a weight loss competition at the Health Management Center of Beilun People's Hospital in Ningbo City were selected as study subjects. They were divided into a control group and an intervention group. The control group received conventional weight management, while the intervention group received the multidisciplinary integrated weight management in addition to the conventional weight management, for a total intervention period of 8 weeks. Weight, body mass index (BMI), waist circumference, hip circumference, waist-to-hip ratio, fasting blood glucose (FBG), triglycerides (TG), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and blood pressure were collected before and after the intervention through physical examinations and laboratory tests. The generalized estimating equations (GEE) method was employed to analyze the differences in indicators between the two groups before and after the intervention. Results The control group comprised 241 participants, including 161 females (66.80%), with a mean age of (35.66±7.80) years. The intervention group consisted of 127 participants, including 86 females (67.72%), with a mean age of (36.80±7.05) years. No statistically significant differences were observed between the two groups at baseline in terms of age, gender, weight, BMI, or waist-to-hip ratio (all P>0.05). Results from the GEE analysis indicated significant interactions between group and time for weight, BMI, waist circumference, and hip circumference (all P<0.05) with greater reductions in these parameters observed in the intervention group compared to the control group before and after the intervention. Similarly, significant interactions between group and time were observed for FBG, TG, TC, and LDL-C (all P<0.05), with the intervention group demonstrating larger decreases in these markers compared to the control group. However, no statistically significant interactions between group and time were observed for waist-to-hip ratio, HDL-C, systolic blood pressure, and diastolic blood pressure (all P>0.05). Following the intervention, a weight loss exceeding 10% was achieved by 13 participants (5.39%) in the control group and 62 participants (48.82%) in the intervention group. The proportion of individuals with a weight loss exceeding 10% was significantly higher in the intervention group compared to the control group (P<0.05). Conclusion Compared to conventional weight management, multidisciplinary integrated weight management demonstrated greater efficacy in improving weight-related indicators and blood glucose, blood lipids, and enhancing weight loss outcomes among overweight and obese residents.
[1] 中国营养学会肥胖防控分会,中国营养学会临床营养分会,中华预防医学会行为健康分会,等.中国居民肥胖防治专家共识[J].中国预防医学杂志,2022,23(5):321-339. Chinese Nutrition Society Obesity Prevention and Control Section,Chinese Nutrition Society Clinical NutritionSection,Chinese Preventive Medicine Association Behavioral Health Section,et al.Expert consensus on obesity prevention and treatment in China[J].Chin Prev Med,2022,23(5):321-339.(in Chinese) [2] 中国疾病预防控制中心,国家癌症中心,国家心血管病中心.中国居民营养与慢性病状况报告(2020年)[M].北京:人民卫生出版社,2022. Chinese Center for Disease Control and Prevention,National Cancer Center,National Center for Cardiovascular Diseases.Report on the nutrition and chronic diseases status of Chinese residents 2020[M].Beijing:People's Medical Publishing House,2022.(in Chinese) [3] TREMMEL M,GERDTHAM U G,NILSSON P M,et al.Economic burden of obesity:a systematic literature review[J/OL].Int J Environ Res Public Health,2017,14(4)[2025-10-28].https://doi.org/10.3390/ijerph14040435. [4] 周梦怡,苏丹婷,何梦洁,等.植物性饮食与不同肥胖类型的关联研究[J].预防医学,2025,37(8):773-778. ZHOU M Y,SU D T,HE M J,et al.Association between plant-based diet and different types of obesity[J].China Prev Med J,2025,37(8):773-778.(in Chinese) [5] 程文迪,刘佳美,王海银,等.我国公立医院体重管理中心和门诊建设现状研究[J].健康发展与政策研究,2025,28(4):372-378,385. CHENG W D,LIU J M,WANG H Y,et al.The current status of weight management centers and outpatient clinics in China's public hospitals[J].Health Dev Policy Res,2025,28(4):372-378,385.(in Chinese) [6] JOHNSTON C A,MORENO J P,FOREYT J P.Cardiovascular effects of intensive lifestyle intervention in type 2 diabetes[J].Curr Atheroscler Rep,2013,369(2):145-154. [7] 刘万奇,杨金侠,谢翩翩,等.我国慢病一体化管理的现状与思考[J].南京医科大学学报(社会科学版),2019,19(4):303-307. LIU W Q,YANG J X,XIE P P,et al.Current situation and thinking of integrated management of chronic diseases in China[J].J Nanjing Med Univ Soc Sci,2019,19(4):303-307.(in Chinese) [8] 董崇林,贾荣娟,侯建华,等.基于微信平台健康管理方案对超重和肥胖糖尿病高危人群的干预效果分析[J].中华健康管理学杂志,2017,11(6):531-536. DONG C L,JIA R J,HOU J H,et al.Intervention effects of health management program based on WeChat platform for high-risk obese diabetic population[J].Chin J Health Manag,2017,11(6):531-536.(in Chinese) [9] 刘芳,李欣,叶明浩,等.医院-社区-家庭模式对社区肥胖儿童青少年体质量的管理效果研究[J].中国全科医学,2020,23(19):2458-2461. LIU F,LI X,YE M H,et al.Effects of hospital-community-family model on weight management of obese children and adolescents[J].Chin Gen Pract,2020,23(19):2458-2461.(in Chinese) [10] 何向阳,刘峥,徐英,等.肥胖与四种常见慢性病的相关性分析[J].预防医学,2020,32(7):692-697. HE X Y,LIU Z,XU Y,et al.Correlation between obesity and four common chronic diseases[J].China Prev Med J,2020,32(7):692-697.(in Chinese) [11] 张露,冯文焕,王静,等.移动医疗应用程序在肥胖多学科门诊体重管理中的作用[J].江苏医药,2022,48(3):231-236,242. ZHANG L,FENG W H,WANG J,et al.Effect of mobile health application on weight management in obesity multidisciplinary clinic[J].Jiangsu Med J,2022,48(3):231-236,242.(in Chinese) [12] 伍朝春,黄政德,庞羽,等.肥胖症多学科协作诊疗模式研究进展[J].实用医学杂志,2023,39(12):1588-1592. WU C C,HUANG Z D,PANG Y,et al.Research progress of multi-disciplinary collaborative diagnosis and treatment model of obesity[J].J Pract Med,2023,39(12):1588-1592.(in Chinese) [13] 李萍,王海雪,高晓,等.基于移动健康技术对超重或肥胖孕妇体重管理的随机对照试验[J].北京大学学报(医学版),2025,57(3):465-472. LI P,WANG H X,GAO X,et al.A randomized controlled trial of weight management based on mobile health techno-logy among overweight or obese pregnant women[J].J Peking Univ Health Sci,2025,57(3):465-472.(in Chinese) [14] YEN H Y,JIN G,CHIU H L.Smartphone app-based interventions targeting physical activity for weight management:a meta-analysis of randomized controlled trials[J/OL].Int J Nurs Stud,2023,137[2025-10-28].https://doi.org/10.1016/j.ijnurstu.2022.104384.
