Abstract：Schizophrenia is a common serious mental disorder, and genetic and environmental factors jointly contribute to the pathogenesis of schizophrenia. A correlation has been found between atmospheric particulate matter and the risk of schizophrenia, and short-term exposure to fine particulate matter (PM2.5) and inhalable particulate matter (PM10) may pose lagged and cumulative effects on the development of schizophrenia. Based on review of national and international publications, this review summarizes the associations between exposure to PM2.5 and PM10 and the risk of schizophrenia, so as to provide insights into the management of schizophrenia.
李链, 王玉成, 王云锋, 边国林. 大气颗粒物与精神分裂症发病关联的流行病学研究进展[J]. 预防医学, 2022, 34(10): 1007-1010.
LI Lian, WANG Yucheng, WANG Yunfeng, BIAN Guolin. Association between atmospheric particulate matter and schizophrenia: a review of epidemiological studies. Preventive Medicine, 2022, 34(10): 1007-1010.
[1] HE H,LIU Q,LI N,et al.Trends in the incidence and DALYs of schizophrenia at the global,regional and national levels:results from the Global Burden of Disease Study 2017[J/OL].Epidemiol Psychiatr Sci,2020,29[2022-08-28].http://doi.org.10.1017/S2045796019000891. [2] JAUHAR S,JOHNSTONE M,MCKENNA P J.Schizophrenia[J].Lancet,2022,399(10323):473-486. [3] MCCUTCHEON R A,REIS MARQUES T,HOWES O D.Schizophrenia-an overview[J].JAMA Psychiatry,2020,77(2):201-210. [4] ATTADEMO L,BERNARDINI F.Air pollution and urbanicity:common risk factors for dementia and schizophrenia?[J]Lancet Planet Health,2017,1(3):e90-e91. [5] 孔德慧,范中杰.空气细颗粒物污染对卒中影响研究进展[J].中国公共卫生,2018,34(2):309-312. KONG D H,FAN Z J.Progress in researches on effect of fine particulate pollution on stroke[J].Chin J Public Health,2018,34(2):309-312. [6] VOLIOTIS A,KARALI I,KOURAS A,et al.Fine and ultrafine particle doses in the respiratory tract from digital printing operations[J].Environ Sci Pollut Res Int,2017,24(3):3027-3037. [7] LARY D J,LARY T,SATTLER B.Using machine learning to estimate global PM2.5 for environmental health studies[J].Environ Health Insights,2015,9(Suppl.1):41-52. [8] EGUCHI R,ONOZUKA D,IKEDA K,et al.The relationship between fine particulate matter(PM2.5)and schizophrenia severity[J].Int Arch Occup Environ Health,2018,91(5):613-622. [9] QIU X,DANESH-YAZDI M,WEI Y,et al.Associations of short-term exposure to air pollution and increased ambient temperature with psychiatric hospital admissions in older adults in the USA:a case-crossover study[J].Lancet Planet Health,2022,6(4):e331-e341. [10] GAO J,WEI Q,PAN R,et al.Elevated environmental PM2.5 increases risk of schizophrenia relapse:mediation of inflammatory cytokines[J/OL].Sci Total Environ,2021,753[2022-8-28].http://10.1016/j.scitotenv.2020.142008. [11] 段俊,罗雪莲,储文革,等.2014—2017年安徽省铜陵市大气PM2.5和温度交互作用对精神分裂症患者入院影响的时间序列分析[J].中华预防医学杂志,2019,53(1):51-56. DUAN J,LUO X L,CHU W G,et al.Time series analysis on the effect of ambient fine particulate matters and temperature interactions on schizophrenia admission in Tongling City of Anhui Province,2014-2017[J].Chin J Prev Med,2019,53(1):51-56. [12] JI Y,LIU B,SONG J,et al.Short-term effects and economic burden assessment of ambient air pollution on hospitalizations for schizophrenia[J].Environ Sci Pollut Res Int,2022,29(30):45449-45460. [13] JI Y,LIU B,SONG J,et al.Particulate matter pollution associated with schizophrenia hospital re-admissions:a time-series study in a coastal Chinese city[J].Environ Sci Pollut Res Int,2021,28(41):58355-58363. [14] BAI L,YANG J,ZHANG Y,et al.Durational effect of particulate matter air pollution wave on hospital admissions for schizophrenia[J/OL].Environ Res,2020,187[2022-08-28].https://doi.org/10.1016/j.envres.2020.109571. [15] QIU H,ZHU X,WANG L,et al.Attributable risk of hospital admissions for overall and specific mental disorders due to particulate matter pollution:a time-series study in Chengdu,China[J].Environ Res,2019,170:230-237. [16] GAO Q,XU Q,GUO X,et al.Particulate matter air pollution associated with hospital admissions for mental disorders:a time-series study in Beijing,China[J].Eur Psychiatry,2017,44:68-75. [17] NGUYEN A M,MALIG B J,BASU R.The association between ozone and fine particles and mental health-related emergency department visits in California,2005-2013[J/OL].PLoS One,2021,16(4)[2022-08-28].https://doi.org/10.1371/journal.pone.0249675. [18] SONG J,ZHENG L,LU M,et al.Acute effects of ambient particulate matter pollution on hospital admissions for mental and behavioral disorders:a time-series study in Shijiazhuang,China[J].Sci Total Environ,2018,636:205-211. [19] LI H,ZHANG S,QIAN Z M,et al.Short-term effects of air pollution on cause-specific mental disorders in three subtropical Chinese cities[J/OL].Environ Res,2020,191[2022-08-28].https://doi.org/10.1016/j.envres.2020.110214. [20] LIANG Z,XU C,CAO Y,et al.The association between short-term ambient air pollution and daily outpatient visits for schizophrenia:a hospital-based study[J].Environ Pollut,2019,244:102-108. [21] 白丽君. 合肥地区2014—2016年交通相关污染物极端暴露对精神分裂症发作的影响[D].合肥:安徽医科大学,2019. BAI L J.Extreme traffic-related air pollution and hospital admissions for schizophrenia:a time-series study in Heifei during 2014-2016[D].Hefei:Anhui Medical University,2019. [22] DUAN J,CHENG Q,LUO X,et al.Is the serious ambient air pollution associated with increased admissions for schizophrenia?[J].Sci Total Environ,2018,644:14-19. [23] ANTONSEN S,MOK P L H,WEBB R T,et al.Exposure to air pollution during childhood and risk of developing schizophrenia:a national cohort study[J].Lancet Planet Health,2020,4(2):e64-e73. [24] LOWE S R,WANG C,MA Y,et al.Particulate matter pollution and risk of outpatient visits for psychological diseases in Nanjing,China[J/OL].Environ Res,2021,193[2022-08-28].https://doi.org/10.1016/j.envres.2020.110601. [25] GENC S,ZADEOGLULARI Z,FUSS S H,et al.The adverse effects of air pollution on the nervous system[J/OL].J Toxicol,2012[2022-08-28].https://doi.org/10.1155/2012/782462. [26] SHABANI S.A mechanistic view on the neurotoxic effects of air pollution on central nervous system:risk for autism and neurodegenerative diseases[J].Environ Sci Pollut Res Int,2021,28(6):6349-6373. [27] DE PRADO B P,MERCADER E M H,PUJOL J,et al.The effects of air pollution on the brain:a review of studies interfacing environmental epidemiology and neuroimaging[J].Curr Environ Health Rep,2018,5(3):351-364. [28] BODA E,RIGAMONTI A E,BOLLATI V.Understanding the effects of air pollution on neurogenesis and gliogenesis in the growing and adult brain[J].Curr Opin Pharmacol,2020,50:61-66. [29] ATTADEMO L,BERNARDINI F,GARINELLA R,et al.Environmental pollution and risk of psychotic disorders:a review of the science to date[J].Schizophr Res,2017,181:55-59. [30] GUILARTE T R,OPLER M,PLETNIKOV M.Is lead exposure in early life an environmental risk factor for schizophrenia?Neurobiological connections and testable hypotheses[J].Neurotoxicology,2012,33(3):560-574. [31] OUDIN A,SEGERSSON D,ADOLFSSON R,et al.Association between air pollution from residential wood burning and dementia incidence in a longitudinal study in Northern Sweden[J/OL].PLoS One,2018,13(6)[2022-08-28].https://doi.org/10.1371/ journal.pone.0198283.
