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预防医学  2017, Vol. 29 Issue (3): 251-254,259    DOI: 10.19485/j.cnki.issn1007-0931.2017.03.009
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抑制素A、激活素A与子宫动脉搏动指数联合预测子痫前期的效果分析
李丽洁,王梁萍,郑艳鹛
浙江省人民医院产科,浙江杭州 310014
An analysis on inhibin A and activin A combined with uterine artery doppler in the prediction of preeclampsia
LI Li-jie,WANG Liang-ping,ZHENG Yan-mei
Departments of Endocrinology,Zhejiang Provincial People's Hospital,Hangzhou,Zhejiang,310014,China
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摘要 目的 评价在不同孕周联合应用抑制素A、激活素A水平及子宫动脉搏动指数(UAPI)3个指标对子痫前期(PE)的预测价值。方法 选择2014年7月—2015年9月在浙江省人民医院产检的孕9~16周单胎初孕产妇400人作为研究对象,采用酶联免疫吸附试验(ELISA)检测抑制素A、激活素A,经多普勒超声检测UAPI值,绘制受试者工作特征曲线(ROC)计算联合检测的特异度和灵敏度。结果 本研究失访23人,失访率为5.75%。孕9~12周组PE 10例,PE发生率为5.35%;孕13~16周组PE 9例,PE发生率为4.74%。孕9~12周和孕13~16周的PE组血清抑制素A、激活素A浓度及UAPI值均高于孕9~12周和孕13~16周的正常组(P<0.05);经ROC曲线分析,孕9~12周3个指标联合应用后曲线下面积(AUC)=0.836,特异度为72%,灵敏度是83%;孕13~16周联合应用AUC=0.912,特异度是87%,灵敏度是86%。结论 孕13~16周时联合应用外周血抑制素A、激活素A及UAPI预测PE的特异度和灵敏度高于孕9~12周。
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李丽洁
王梁萍
郑艳鹛
关键词 子痫前期抑制素A激活素A子宫动脉搏动指数    
AbstractObjective To evaluate the predictive value of pre-eclampsia with the combination of inhibin A,activin A and uterine artery doppler.Methods The single pregnant pregnant women were divided into 9-12 week of pregnancy groups and 13-16 week of gestation group based on examination of gestational age.According to the outcome of further follow-up the women are divided into normal pregnancy (9-12 week pregnant or 13-16 week pregnant normal group) and the PE group (9-12 weeks pregnant or pregnant 13-16 PE group).Enzyme-linked immunosorbent assay (ELISA) was used to detect the concentration of inhibin A and activin A.Doppler ultrasound were used to examine UAPI.The results were converted to MoM values to calculate the combined detection specificity and sensitivity.Results The concentration of serum inhibin A and activin A and UAPI in 9-12 week pregnant PE group were significantly higher than that in 9-12 week normal pregnant (P<0.05).The concentration of serum inhibin A and activin A and UAPI in 13-16 week pregnant PE group were significantly higher than that in 13-16 week normal pregnant (P<0.05).When the maximum area under the curve of three indicator combined application (AUC=0.836) in 9-12 week pregnant,the specificity was 72% and the sensitivity was 83%.When the maximum area under the curve of three indicators combined application (AUC=0.912) in 13-16 week pregnant,the specificity was 87% and the sensitivity was 86%.Conclusion The combined application of peripheral blood inhibin A,activin A and UAPI could predict PE.The combined application of indicator detection index provides a high degree of specificity,sensitivity and predictive value in 13-16 week pregnant.
Key wordsPre-eclampsia;Inhibin A;Activin A    Uterine artery pulsation index
          出版日期: 2017-03-15
中图分类号:  R714.244  
基金资助:2012年省医药卫生平台重点资助计划(2012KYA019)
作者简介: 李丽洁,硕士,副主任医师,主要从事围产医学研究工作
通信作者: 李丽洁,E-mail:lxb0317@yeah.net   
引用本文:   
李丽洁, 王梁萍, 郑艳鹛. 抑制素A、激活素A与子宫动脉搏动指数联合预测子痫前期的效果分析[J]. 预防医学, 2017, 29(3): 251-254,259.
LI Li-jie, WANG Liang-ping, ZHENG Yan-mei. An analysis on inhibin A and activin A combined with uterine artery doppler in the prediction of preeclampsia. Preventive Medicine, 2017, 29(3): 251-254,259.
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http://www.zjyfyxzz.com/CN/10.19485/j.cnki.issn1007-0931.2017.03.009      或      http://www.zjyfyxzz.com/CN/Y2017/V29/I3/251
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