Abstract：Objective In order to investigate the Mycoplasma pneumonia（MP）infection and drug resistance in children in Fuyang,Hangzhou,and to provide a rational basis for the clinical diagnosis and treatment of MP in children. Methods A total of 1104 respiratory tract samples were collected from children patients with pneumonia. MP and its mutations in 23S rRNA gene locus were detected by real-time PCR. Then analyze pertinence between the clinical data and experimental results were conducted. Results Among 1104 respiratory tract samples,175 cases（15.85%）were MP positive. Moreover,the mutation of 23S rRNA gene locus existed in 115 MP positive samples with the positive infection rate of 65.71%. The infection rate （25.74%）and mutation rate（82.69%）in summer（Jul.-Sep.）was higher than other seasons,and the infection rate （11.72%）and mutation rate（40.63%）was the lowest in winter（Jan.-Mar.）. The infection rates of male and female children were 66.67% and 64.56%,and the mutation rates of male and female children were 66.67% and 64.56%. Conclusion MP infection may be related with climate and age. 23S rRNA gene locus mutation has a higher detection rate,prompting that MP shows high resistant rate to macrolides.
骆文龙, 杨雨, 韩徐芳, 郑银娜. 富阳区儿童肺炎支原体感染及耐药分析[J]. 预防医学, 2018, 30(3): 257-259,265.
LUO Wen-long*, YANG Yu, HAN Xu-fang, ZHENG Yin-na. Mycoplasma pneumoniae infection and drug resistance among children in Fuyang District. Preventive Medicine, 2018, 30(3): 257-259,265.
