Abstract：Objective To explore vaccine immune effects of 60 μg hepatitis B on adults who have no response to hepatitis B vaccination.Methods A Total of 689 healthy adults who were HBsAg and anti- HBs negative were selected,and they were received 3 doses of hepatitis B vaccine at dosage 10 μg. Those with anti- HBs＜10 IU/L detected after full series vaccination were given 1 dose of hepatitis B vaccine at dosage 60 μg.One month later,anti- HBs detection was conducted for them.Results The non -responsiveness rate was 17.71% after primary hepatitis B vaccination. The multivariate logistic regression analysis showed that risk factors for primary non-responsiveness were the history of surgical operation, immunization schedule and "anti-HBc alone". The anti- HBs positive rate was 95.51% in 89 re-vaccinated people,and the geometric mean titers of anti-HBs(GMT) was 585.39 IU/L.Conclusion Re-immunization of hepatitis B vaccine at dosage 60 μg has good immunogenicity in people who have no response to primary vaccination, and weight control may improve the effect of hepatitis B re-immunization.
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