Abstract：The prevention and treatment of latent tuberculosis infection (LTBI) is a key strategy to achieve the World Health Organization (WHO) End Tuberculosis (TB) Strategy 2035 goal. Jiangsu Province serves as a global model for LTBI control, and provide valuable experience for regional tuberculosis prevention. This paper reviews the policy evolution and implementation progress of LTBI control in Jiangsu Province. The Jiangsu province has issued a specific prevention plan. It has established a preventive treatment service system for specialized clinics and a digital service platform. Positive results have been achieved in screening key populations, promoting short-course preventive regimens, and follow-up management. Although the reported TB incidence in Jiangsu Province remains low, the LTBI detection rate is high in both the general and high-risk populations. The prevention and control of LTBI faces serious challenges, including uneven coverage of high-risk populations, room for improvement in the rate of preventive treatment, weak digital management capabilities at the grassroots level, and poor interdepartmental coordination. It is recommended to further expand screening coverage, strengthen health education to improve the acceptance and completion rates of preventive treatment, deepen multisectoral collaboration and data integration, and enhance the construction of grassroots intelligent management systems, thereby providing support for regional tuberculosis prevention and control.
[1] World Health Organization.Global vaccine market report 2024[R].Geneva:WHO,2025. [2] 马艳,成诗明.加速我国结核潜伏感染筛查与预防性治疗的建议[J].实用医学杂志,2023,39(11):1335-1340. [3] KIM S,THAL R,SZKWARKO D.Management of latent tuberculosis infection[J/OL].JAMA,2023,329(5)[2026-05-01].https://doi.org/10.1001/jama.2022.24362. [4] 刘宇红.浅读世界卫生组织《潜伏结核感染管理指南》[J].临床肺科杂志,2015,20(10):1915-1916. [5] 欧明展.江苏省东台市农村地区自然人群中结核分枝杆菌感染情况的流行病学研究[D].厦门:厦门大学,2014. [6] 卢鹏,丁慧,刘巧,等.基于人群横断面调查的卡介苗卡痕数量与结核潜伏感染风险关系的探讨[J].江苏预防医学,2025,36(2):140-143,147. [7] 孔雯,刘巧,卢鹏,等.江苏省部分地区结核潜伏性感染影响因素研究[J].江苏预防医学,2018,29(3):244-246. [8] ZHANG Y,LU P,WU K,et al.Positive rate and risk factors of latent tuberculosis infection among persons living with HIV in Jiangsu Province,China[J/OL].Front Cell Infect Microbiol,2023,13[2026-05-01].https://doi.org/10.3389/fcimb.2023.1051060. [9] 王慧,李锦成,陆兴,等.重组结核杆菌融合蛋白皮肤试验筛查HIV/AIDS病例结核分枝杆菌潜伏感染的效果分析[J].预防医学,2024,36(7):639-643. [10] 蒋骏,李云,姜伟,等.肺结核密切接触者结核分枝杆菌潜伏感染情况及影响因素分析[J].结核与肺部疾病杂志,2023,4(4):318-322. [11] 汤玲,王小平.南通市海门区活动性肺结核患者家庭密切接触者筛查及筛查后处理情况[J].江苏预防医学,2025,36(2):221-223. [12] LIU Q,LU P,MARTINEZ L,et al.Undiagnosed diabetes mellitus and tuberculosis infection:a population-based,observational study from Eastern China[J/OL].Diabetes Metab Res Rev,2020,36(3)[2026-05-01].https://doi.org/10.1002/dmrr.3227. [13] 孙郑,刘炯雅,刘巧,等.中国东部职业接尘退休矿工结核潜伏感染现状及相关危险因素分析[J].中国热带医学,2026,26(2):188-192. [14] HU X S,CHEN C,GAO Q Q,et al.Latent tuberculosis infection and infection-associated risk factors for miner workers with silicosis in Eastern China[J/OL].BMC Pulm Med,2024,24(1)[2026-05-01].https://doi.org/10.1186/s12890-024-02985-z. [15] ZHOU Y Y,LV X,ZHU S,et al.The characteristics of latent tuberculosis infection and its influencing factors in hospitalized patients in Suzhou,Jiangsu,China[J/OL].PLoS One,2025,20(6)[2026-05-01].https://doi.org/10.1371/journal.pone.0322913. [16] LIU Y,HUANG S,JIANG H,et al.The prevalence of latent tuberculosis infection in rural Jiangsu,China[J].Public Health,2017,146:39-45. [17] 李忠奇,王展,卢鹏,等.室外SO2和NO2暴露与中学生结核潜伏感染风险的关联研究[J].中国热带医学,2024,24(10):1268-1275. [18] 江苏省卫生健康委员会.江苏省“十四五”结核病防治规划[EB/OL].[2026-05-01].https://wjw.jiangsu.gov.cn/art/2021/11/16/art_49495_10114796.html. [19] 江苏省卫生健康委员会.江苏省学校结核病防控工作规范[EB/OL].[2026-05-01].https://wjw.jiangsu.gov.cn/art/2022/9/16/art_92704_10606657.html. [20] 江苏省卫生健康委员会.江苏省“十五五”结核病防治规划[EB/OL].[2026-05-01].https://wjw.jiangsu.gov.cn/art/2025/12/31/art_92704_11703481.html. [21] World Health Organization.Scaling up TB preventive treatment in China[EB/OL].[2026-05-01].https://www.who.int/teams/global-programme-on-tuberculosis-and-lung-health/tb-reports/global-tuberculosis-report-2025/featured-topics/tb-preventive-treatment-in-china. [22] 丁晓艳,蒋晖,薛浩,等.江苏省“十三五”期间学校结核病防控工作实施情况[J].中国热带医学,2022,22(8):707-711. [23] 倪晗,于全骥,邵燕,等.2014—2024年江苏省学生肺结核流行病学特征分析[J].江苏预防医学,2025,36(2):160-163. [24] 马艳,陆伟,高磊,等.终止结核病流行须加强结核分枝杆菌潜伏感染高危人群筛查和预防性治疗的管理[J].中国防痨杂志,2022,44(3):209-214. [25] 倪晗,虞浩,丁晓艳,等.江苏省2019—2022年遏制结核病行动计划实施效果[J].江苏预防医学,2023,34(3):252-255.
