Survival analysis of female breast cancer patients in Panyu District
YOU Na1, LIANG Xiaoxian1, LAI Chunyan2, RUAN Huihong3
1. Panyu District Center for Chronic Disease Control, Guangzhou, Guangdong 511400, China; 2. Panyu District Center for Disease Control and Prevention, Guangzhou, Guangdong 511400, China; 3. Panyu District Hualong Town Community Health Service Center, Guangzhou, Guangdong 511400, China
Abstract：Objective To investigate the survival rate of female breast cancer patients in Panyu District, Guangzhou City, so as to provide the basis for improving the prognosis of breast cancer patients. Methods Basic information including age, clinical stage and surgical treatment of female breast cancer patients registered in Panyu District and diagnosed in 2017 were collected through the Guangzhou Municipal Cancer Registration and Reporting Management System, and were followed up until December 31, 2022. The survival rate was calculated using the life table. Factors affecting survival time among female breast cancer patients were analyzed using a multivariable Cox proportional hazard regression model. Results A total of 227 female breast cancer patients were reported in Panyu District in 2017, and had a median age of 51 (interquartile range, 17) years. There were 43 cases (18.94%) in stage Ⅰ, 55 cases (24.23%) in stage Ⅱ, 63 cases (27.75%) in stage Ⅲ, 27 cases (11.89%) in stage Ⅳ, and 39 cases (17.18%) with unknown staging. Surgical treatment was performed in 204 cases (89.87%), and chemotherapy was administered in 73 cases (32.16%). By December 31, 2022, there were 40 deaths and 14 patients lost to follow-up. The one-year, three-year and five-year survival rates were 96.44%, 87.45% and 82.87%, respectively. Multivariable Cox proportional hazard regression analysis showed that older age (HR=1.023, 95%CI: 1.002-1.046), clinical stage Ⅲ (HR=10.050, 95%CI: 1.324-76.270) or IV (HR=42.663, 95%CI: 5.588-325.742) were associated with a higher risk of mortality in female breast cancer patients, while surgical treatment (HR=0.278, 95%CI: 0.130-0.598) was associated with a lower risk of mortality. Conclusions The five-year survival rate of female breast cancer patients in Panyu District was 82.87%. Age, clinical stage and surgical treatment were the main influencing factors for the survival time of female breast cancer patients.
[1] 曹毛毛,陈万青.GLOBOCAN 2020全球癌症统计数据解读[J].中国医学前沿杂志(电子版),2021,13(3):63-69. CAO M M,CHEN W Q.Interpretation on the global cancer statistics of GLOBOCAN 2020[J].Chin J Front Med Sci(Electron Version),2021,13(3):63-69.(in Chinese) [2] 由娜,阮慧红,邢启明,等.2019年广州市番禺区恶性肿瘤发病与预后[J].热带医学杂志,2022,22(2):278-282. YOU N,RUAN H H,XING Q M,et al.Cancer incidence and prognosis in Panyu district of Guangzhou,2019[J].J Trop Med,2022,22(2):278-282.(in Chinese) [3] 健康中国行动推进委员会.健康中国行动(2019—2030年):总体要求、重大行动及主要指标[J].中国循环杂志,2019,34(9):846-858. Healthy China Action Promotion Committee.Healthy China Action(2019-2030):overall requirements,important actions,and main indicators[J].Chin Circ J,2019,34(9):846-858.(in Chinese) [4] FELAY J,BURKHARD C,WHELAN S,et al.Check and conversion programs for cancer registries.IARC technical report No.42[R].Lyon:IARC,2005. [5] PARKIN D M,BRAY F.Evaluation of data quality in the cancer registry:principles and methods Part Ⅱ.Completeness[J].Eur J Cancer,2009,45(5):756-764. [6] 国家癌症中心.中国肿瘤登记工作指导手册(2016)[M].北京:人民卫生出版社,2016. National Cancer Center.Guidelines for cancer registration in China(2016)[M].Beijing:People's Medical Publishing House,2016.(in Chinese) [7] ZENG H M,CHEN W Q,ZHENG R S,et al.Changing cancer survival in China during 2003-15:a pooled analysis of 17 population-based cancer registries[J].Lancet Glob Health,2018,6(5):555-567. [8] 魏矿荣,梁智恒,李柱明.2003—2013年广东省中山市主要癌症净生存率分析[J].中国肿瘤,2020,29(2):103-107. WEI K R,LIANG Z H,LI Z M.Net survival of major cancers in Zhongshan City of Guangdong Province from 2003 to 2013[J].Chin Cancer,2020,29(2):103-107.(in Chinese) [9] 吴新凡,王临池,张秋,等.苏州市姑苏区2008—2013年恶性肿瘤患者生存分析[J].中国初级卫生保健,2021,35(3):41-44. WU X F,WANG L C,ZHANG Q,et al.Survival of cancer patients in Gusu District of Suzhou,2008-2013[J].Chin Prim Health Care,2021,35(3):41-44.(in Chinese) [10] 韩雪,谢梦,赵佳,等.2002—2012年上海市杨浦区女性人群乳腺癌的发病和生存情况分析[J].中华疾病控制杂志,2015,19(7):708-711. HAN X,XIE M,ZHAO J,et al.The incidence and survival analysis of breast cancer among female residents in Yangpu District of Shanghai from 2002 to 2012[J].Chin J Dis Control Prev,2015,19(7):708-711.(in Chinese) [11] 陈海珍,徐红,吉光,等.2007—2017年江苏省南通市肿瘤医院乳腺癌住院患者生存率分析[J].中国肿瘤,2023,32(11):820-826. CHEN H Z,XU H,JI G,et al.Analysis of survival among breast cancer inpatients in Nantong Tumor Hospital from 2007 to 2017[J].Chin Cancer,2023,32(11):820-826.(in Chinese) [12] 李贺,左婷婷,曾红梅,等.不同年龄女性乳腺癌患者的临床特征及预后分析[J].中华肿瘤杂志,2021,43(1):126-131. LI H,ZUO T T,ZENG H M,et al.Clinical features and prognostic analysis of female breast cancer in different diagnosed ages[J].Chin J Oncol,2021,43(1):126-131.(in Chinese) [13] 王军,陈永胜,丁璐璐,等.1972—2016年江苏省启东市女性乳腺癌生存率趋势分析[J].中国肿瘤,2023,32(3):178-183. WANG J,CHEN Y S,DING L L,et al.Analysis of survival rate trend for female breast cancer in Qidong of Jiangsu,1972-2016[J].Chin Cancer,2023,32(3):178-183.(in Chinese) [14] 徐巧巧,吕萍,颜波儿.乳腺癌患者术后生命质量及影响因素分析[J].预防医学,2017,29(9):906-908,913. XU Q Q,LYU P,YAN B E.Quality of life and its influencing factors in patients with breast cancer after operation[J].China Prev Med J,2017,29(9):906-908,913.(in Chinese) [15] 崔俊鹏,陆艳,黄春妍,等.2007—2021年苏州市女性乳腺癌死亡与减寿分析[J].预防医学,2023,35(5):380-383. CUI J P,LU Y,HUANG C Y,et al.Death and life loss due to female breast cancer in Suzhou City from 2007 to 2021[J].China Prev Med J,2023,35(5):380-383.(in Chinese)
