Analysis of inflammatory indicators in patients with oral squamous cell carcinoma
BAO Zhenying1,2, WANG Yajie1
1. Department of Clinical Laboratory, Beijing Ditan Hospital, Capital Medical University, Beijing 100015, China; 2. Peking University School and Hospital of Stomatology, Beijing 100081, China
Abstract：Objective To examine the inflammatory indicators in patients with oral squamous cell carcinoma (OSCC), so as to provide insights into early screening and recognition of OSCC. Methods A total of 86 OSCC patients, 61 patients with chronic periodontitis (CP) and 71 patients without the above diseases were selected from Peking University Hospital of Stomatology and were enrolled in the OSCC group, CP group and control group. Procalcitonin (PCT), serum amyloid A (SAA), C-reactive protein (CRP), white blood cell count (WBC), neutrophil percentage (NEUT%), neutrophil to lymphocyte ratio (NLR), lymphocyte to monocyte ratio (LMR), platelet count and lymphocyte ratio (PLR) were measured in peripheral blood. Receiver operating characteristic (ROC) curves were used to evaluate the effectiveness of the aforementioned inflammatory indicators in OSCC screening. Results The OSCC group consisted of 46 males and 40 females, with a median age of 59.50 (interquartile range, 18.25) years; the CP group consisted of 32 males and 29 females, with a median age of 53.00 (interquartile range, 14.50) years; the control group consisted of 36 males and 35 females, with a median age of 54.00 (interquartile range, 16.00) years. Compared with the control group and the CP group, the PCT, SAA, CRP, WBC, NEUT%, NLR and PLR in the OSCC group were increased, and the LMR was decreased, and the difference was statistically significant (all P<0.05). The combined use of PCT, SAA and CRP had a good effect in distinguishing the OSCC group from the control group, with an area under the ROC curve (AUC) of 0.992, which was higher than the individual identification of the 8 indicators (all P<0.05). The combined use of PCT, WBC, and NLR also had a good effect in distinguishing the OSCC group from the CP group, with an AUC value of 0.841, which was higher than the individual identification of WBC, LMR and PLR (all P<0.05). Conclusion Compared with patients with CP, as well as patients without OSCC and CP, patients with OSCC exhibit significant differences in inflammatory indicator levels, which may facilitate early identification of OSCC.
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