Investigation on the use of new types of drugs among HIV/AIDS patients in Ningbo City
JIANG Haibo1, HONG Hang2, ZHOU Jian3, LI Jige3, SHI Hongbo1, TAN Shiwen1, CHU Kun1, ZHANG Dandan1
1. Institute for AIDS/STDs Control and Prevention, Ningbo Center for Disease Control and Prevention, Ningbo, Zhejiang 315010, China; 2. Ningbo University, Ningbo, Zhejiang 315211, China; 3. Ningbo Center for Disease Control and Prevention, Ningbo, Zhejiang 315010, China
Abstract：Objective To investigate the use of new types of drugs among HIV/AIDS patients in Ningbo City, Zhejiang Province, so as to provide insights into surveillance and interventions for use of new types of drugs among HIV/AIDS patients. Methods The HIV/AIDS patients in Ningbo City were randomly sampled from the HIV/AIDS Prevention and Control Information System of Chinese Disease Prevention and Control Information System. Patients' demographics, use of new types of drugs and sexual behaviors were collected using questionnaire surveys. Patients' hair samples were collected, and new types of drugs were determined in hair using liquid chromatography-mass spectrometry (LC-MS). In addition, factors affecting the use of new types of drugs were identified using a multivariable logistic regression model. Results A total of 254 HIV/AIDS patients were enrolled, including 214 men (84.25%), 31 cases aged under 25 years (12.20%), 66 cases aged 25 to 30 years (25.98%), and 157 cases aged 31 to 75 years (61.81%). There were 30 cases reported previous use of new drugs (11.81%), including 27 cases reported previous use of methamphetamine (90.00%). There were 48 cases tested positive of new types of drugs, with a positive rate of 18.90%, including 44 cases tested positive for methamphetamine (91.67%). Multivariable logistic regression analysis identified age (25 to 30 years, OR=6.926, 95%CI: 1.412-33.969), occupation (students/teachers/cadres/employees/retirees, OR=6.971, 95%CI: 2.123-22.889; housekeeping and housework servants/unemployed, OR=3.356, 95%CI: 1.289-8.739; business/public place servants, OR=2.447, 95%CI: 1.033-4.448) and syphilis infection during recent six months (OR=3.491, 95%CI: 1.664-7.326) as factors affecting the use of new types drugs among HIV/AIDS patients. Conclusions The use of new types of drugs exists in HIV/AIDS patients in Ningbo City. Age, occupation and syphilis infection were associated with the use of new types of drugs among HIV/AIDS patients.
姜海波, 洪航, 周健, 李继革, 史宏博, 谭诗文, 褚堃, 张丹丹. 宁波市HIV/AIDS病例新型毒品使用情况调查[J]. 预防医学, 2023, 35(6): 470-474.
JIANG Haibo, HONG Hang, ZHOU Jian, LI Jige, SHI Hongbo, TAN Shiwen, CHU Kun, ZHANG Dandan. Investigation on the use of new types of drugs among HIV/AIDS patients in Ningbo City. Preventive Medicine, 2023, 35(6): 470-474.
[1] 姜海波,曹晓斌,王常合,等.HIV阳性美沙酮维持治疗者新型毒品使用情况及其影响因素分析[J].中华流行病学杂志,2014,35(8):905-908. [2] 杨凤瑞. 新型毒品防范手册[M].北京:法律出版社,2005:2-5. [3] 王瑞,卫晓丽,张海兰,等.西安市强制隔离戒毒人员艾滋病高危行为分析[J].预防医学,2020,32(10):1018-1021. [4] 石慧,李十月,王棠,等. 武汉市青少年男男性接触者药物滥用及影响因素[J]. 中国公共卫生,2016,32(3):329-332. [5] 中华人民共和国公安部令.公安部关于修改《吸毒检测程序规定》的决定[EB/OL].[2023-04-23].http://www.gov.cn/gongbao/content/2017/content_5213188.htm. [6] 谢普,王铁杰,殷果,等.UPLC-MS/MS法测定吸毒者头发中10种毒品代谢物的含量[J].药物分析杂志,2014,34(3):516-522. [7] PRAGST F,BALIKOVA M A.State of the art in hair analysis for detection of drug and alcohol abuse[J].Clin Chim Acta,2006,370(1/2):17-49. [8] HE L,PAN X,WANG N,et al.New types of drug use and risks of drug use among men who have sex with men:a cross-sectional study in Hangzhou,China[J].BMC Infect Dis,2018,18(1):1-9. [9] 徐文贤,朱武通,葛锐,等.社区戒毒人员梅毒和丙型肝炎感染状况调查[J].预防医学,2017,29(2):135-138. [10] 姜海波,张丹丹,洪航,等.宁波市2017—2020年新确证HIV/AIDS中新发感染病例特征及其影响因素分析[J].中华流行病学杂志,2021,42(12):2112-2117. [11] 何佳晋,居豪,吴超.中国MSM人群HIV新发感染率及其影响因素的Meta分析[J].预防医学,2022,34(1):70-77. [12] CAMONI L,DAL C I,REGINE V,et al.Sexual behaviour reported by a sample of Italian MSM before and after HIV diagnosis[J].Ann Ist Super Sanita,2011,47(2):214-219. [13] Joint United Nations Programme on HIV/AIDS. 2015 China AIDS response progress report[EB/OL].[2023-04-23].http://www.unaids.org/sites/default/files/country/documents/CHN_narrative_report_2015.pdf. [14] TABB Z J,MMBAGA B T,GANDHI M,et al.Antiretroviral drug concentrations in hair are associated with virologic outcomes among young people living with HIV in Tanzania[J].AIDS,2018,32(9):1115-1123. [15] RÖHRICH C R,DRÖGEMÖLLER B I,IKEDIOBI O,et al.CYP2B6*6 and CYP2B6*18 predict long-term efavirenz exposure measured in hair samples in HIV-positive South African women[J].AIDS Res Hum Retrov,2016,32(6):529-538. [16] 宋炜路,王书江,王莉,等.伊犁州报告为非婚异性性传播的HIV感染者感染原因及真实感染途径复核分析[J].中国艾滋病性病,2016,22(10):822-824,827.
