Abstract：Objective To learn the HIV infection status and related factors among spouses of HIV/AIDS. Methods We recruited HIV/AIDS cases diagnosed between January 2000 and August 2016 in Lu'an and their spouses to collect the demographic information and sexual behavior characteristics. For HIV sero-accordant spouses，we analyzed influencing factors for HIV infection by logistic regression model; while for HIV sero-discordant spouses，we followed up until December 31，2016 and detected their HIV antibody periodically. Results The HIV infection rate of spouses was 20.35%（47/231）. Forty-five of the spouses had been infected with HIV before our investigation，with a infection rate of 19.48%（45/231）. Two of the spouses developed positive HIV antibody during the follow-up with a positive conversion rate of 0.39/100 person-years. Multivariate logistic regression analysis indicated that high frequency of sexual contacts before confirmed as HIV positive（OR≥1/week= 6.268，95%CI：2.313-16.985；OR1/half a month=3.760，95%CI：1.268-11.150）and diagnosis during 2011-2014（OR=3.079，95%CI：1.209-7.841）were the risk factors for HIV transmission between couples; under the age of 25（OR=0.042，95%CI：0.004-0.467）when confirmed as HIV positive and early viral load<300 copies/mL（OR=0.115，95%CI：0.045-0.295）were protective factors. Conclusion HIV transmission of spouses is associated with frequency of sexual contacts，time of diagnosis，age when confirmed as HIV positive and early viral load.
