Abstract：The World Health Organization (WHO) has proposed the goal of ending the tuberculosis (TB) epidemic by 2035, aiming to eliminate the harm of tuberculosis to human health as soon as possible. Based on current context of TB prevention and control in China, this paper proposes strategies of shifting the focus upstream and innovation drive to end the TB epidemic. Shifting the focus upstream mainly relies on proactive screening to control infectious sources, epidemiological investigations to trace and block transmission, and preventive interventions to protect vulnerable populations. Innovation drive primarily depends on technological innovations in TB screening, diagnosis, treatment, and intelligent prevention and control to enhance prevention and control efficacy and accelerate the decline of the epidemic. Challenges remain in the implementation of shifting the focus upstream and innovation drive. It is recommended to enhance government commitment and investment, and adopt measures such as comprehensive interventions in TB-free communities to drive China towards achieving the goal of ending the TB epidemic.
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