Abstract：Objective To examine the effect of moderate aerobic exercise on the 10-year risk of atherosclerotic cardiovascular disease (ASCVD) in patients with hypercholesterolemia, so as to provide insights into ASCVD prevention. Methods The patients with hypercholesterolemia admitted to the Affiliated Hospital of Hebei University from September 2019 to September 2020 were recruited and randomly assigned into the intervention group and the control group using a random number table. Participants in both groups received routine lipid-lowering therapy and health education, and participants in the intervention group were given additional interventions of moderate aerobic exercise. Serum lipid levels were measured before and after 12 weeks of interventions. The 10-year risk of developing ASCVD was evaluated in both groups following interventions. Results There were 50 participants with hypercholesterolemia in each of the intervention and control groups. The mean age was ( 38.80±1.42 ) years in the intervention group and ( 37.14±1.23 ) years in the control group, and males were accounted for 46.00% and 40.00%, respectively. The increase in high-density lipoprotein cholesterol ( HDL-C ), the reduction in total cholesterol ( TC ), triglyceride ( TG ), low-density lipoprotein cholesterol ( LDL-C ) and the 10-year risk of ASCVD were all significantly greater in the intervention group than those in the control group before and after the interventions ( P<0.05 ). Conclusion Moderate aerobic exercise may reduce the 10-year risk of ASCVD through regulating blood lipid levels.
[1] DUNCAN M S,VASAN R S,XANTHAKIS V.Trajectories of blood lipid concentrations over the adult life course and risk of cardiovascular disease and all-cause mortality:observations from the Framingham Study over 35 years[J/OL].J Am Heart Assoc,2019,8(2019-05-29)[2021-10-21].https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6585376.DOI:10.1161/JAHA.118.011433. [2] LI H H,HUANG S,LIU X Z,et al.Applying the China-PAR risk algorithm to assess 10-year atherosclerotic cardiovascular disease risk in populations receiving routine physical examinations in eastern China[J].Biomed Environ Sci,2019,32(2):87-95. [3] LUO J, ZHENG B.Effect of yoga combined with aerobic exercise intervention on morphological and blood lipid indicators in female college students[J].J Sports Med Phys Fitness,2020,60(3):442-448. [4] DA SILVA J L,MARANHÃO R C,SILVA M S M,et al. Aerobic training in young men increases the transfer of cholesterol to high density lipoprotein in vitro:impact of high density lipoprotein size[J].Lipids,2019,54(6/7):381-388. [5] 周欢欢. 抗阻运动对改善2型糖尿病患者心血管风险的效果研究[D].南京:南京中医药大学,2017:6,27-30. ZHOU H H.Effects of resistance exercise on cardiovascular risk in type 2 diabetes patients[D].Nanjing:Nanjing University of Chinese Medicine,2017:6,27-30. [6] JORGE M L M P,DE OLIVEIRA V N,RESENDE N M,et al.The effects of aerobic,resistance,and combined exercise on metabolic control,inflammatory markers,adipocytokines,and muscle insulin signaling in patients with type 2 diabetes mellitus[J].Metabolism,2011,60(9):1244-1252. [7] 诸骏仁,高润霖,赵水平,等.中国成人血脂异常防治指南(2016年修订版)[J].中华心血管病杂志,2016,44(10):833-853. ZHU J R,GAO R L,ZHAO S P,et al.2016 Chinese guideline for the management of dyslipidemia in adults[J].Chin J Cardiol,2016,44(10):833-853. [8] 中华人民共和国国家心血管病中心国家基本公共卫生服务项目基层高血压管理办公室,国家基层高血压管理专家委员会.国家基层高血压防治管理指南2020版[J].中国循环杂志,2021,36(3):209-220. The National Essential Public Health Service Program Office for Management of Hypertension in Primary Health Care,National Center for Cardiovascular Diseases,National Committee on Hypertension in Primary Health Care. National clinical practice guidelines on the management of hypertension in primary health care in China(2020)[J].Chin Circul J,2021,36(3):209-220. [9] 中华医学会糖尿病学分会.中国2型糖尿病防治指南(2020年版)[J].中华糖尿病杂志,2021,13(4):315-409. Chinese Diabetes Society.Guideline for the prevention and treatment of type 2 diabetes mellitus in China(2020 edition)[J].Chin J Diabetes Mellit,2021,13(4):315-409. [10] LIU S W,ZHANG M,YANG L,et al.Prevalence and patterns of tobacco smoking among Chinese adult men and women:findings of the 2010 national smoking survey[J].J Epidemiol Community Health,2017,71(2):154-161. [11] 中华人民共和国国家体育总局.全民健身指南[M].北京:北京体育大学出版社,2019:25,50-86. General Administration of Sports of China.Guide to national fitness[M].Beijing:Beijing Sport University Press,2019:25,50-86. [12] 中国心血管病预防指南(2017)写作组,中华心血管病杂志编辑委员会.中国心血管病预防指南(2017)[J].中华心血管病杂志,2018,46(1):10-25. Chinese Cardiovascular Disease Prevention Guidelines(2017)Writing Group,Editorial Board of Chinese Journal of Cardiology. Chinese guidelines for prevention of cardiovascular disease(2017)[J].Chin J Cardiol,2018,46(1):10-25. [13] ZHANG X G,LIU J,WANG M,et al.Twenty-year epidemiologic study on LDL-C levels in relation to the risks of atherosclerotic event,hemorrhagic stroke,and cancer death among young and middle-aged population in China[J].J Clin Lipidol,2018,12(5):1179-1189. [14] 王亚鑫. 有氧运动通过调控miR-21a诱导的靶基因表达改善高脂血症[D].太原:山西大学,2020:41. WANG Y X.Improvement of hyperlipidemia by aerobic exercise in mice through a regulatory effect of miR-21a on its target genes[D].Taiyuan:Shanxi University,2020:41. [15] SANDESARA P B,VIRANI S S,FAZIO S,et al.The forgotten lipids:triglycerides,remnant cholesterol,and atherosclerotic cardiovascular disease risk[J].Endocr Rev,2019,40(2):537-557. [16] SIDDIQI H K,KISS D,RADER D.HDL-cholesterol and cardiovascular disease:rethinking our approach[J].Curr Opin Cardiol,2015,30(5):536-542. [17] STRANSKA Z,MATOULEK M,VILIKUS Z,et al.Aerobic exercise has beneficial impact on atherogenic index of plasma in sedentary overweigh and obese women[J].Neuro Endocrinol Lett,2011,32(1):102-108. [18] WANG Y T,SHEN L,XU D Y.Aerobic exercise reduces triglycerides by targeting apolipoprotein C3 in patients with coronary heart disease[J].Clin Cardiol,2019,42(1):56-61. [19] LOPRINZI P D,DAVIS R E.Daily movement patterns and predicted 10-yr risk for a first atherosclerotic cardiovascular disease(ASCVD)event using the pooled cohort risk equations among US adults[J].Prev Med,2015,81:78-81. [20] GOROSTEGI-ANDUAGA I,MALDONADO-MARTÍN S,AGUIRRE-BETOLAZA A M,et al.Effects on cardiovascular risk scores and vascular age after aerobic exercise and nutritional intervention in sedentary and overweight/obese adults with primary hypertension:the EXERDIET-HTA randomized trial study[J].High Blood Press Cardiovasc Prev,2018,25(4):361-368.
