Abstract：Objective To examine the independent effect of depression on activities of daily living of patients with mild cognitive impairment （MCI）. Methods Data were obtained through the face-to-face interview. Totally 154 elderly patients that were screened from 552 old people by the Montreal Cognitive Assessment（MoCA）were diagnosed as MCI. They were investigated with the Geriatric Depression Scale,and instrumental ability of daily living（IADL）were measured by the Functional Activities Questionnaire. The effect of depression on IADL of patients with MCI was analyzed by logistic regression analysis. Results The prevalence of depressive symptoms among Chinese elders with MCI was 31.82%. The scores of Medical Outcomes Study Social Support Survey, and Functional Activity Questionnaire of depression group and non-depression group were significantly different （P<0.05）. Logistic regression analysis showed that scores of Functional Activity Questionnaire was positively associated with the scores of Memory Inventory for the Chinese（OR=1.36,95%CI：1.15-1.61）and depression（OR=6.19,95%CI：2.07-18.55）. Conclusion The prevalence of depression in elderly patients with MCI was high. Depression would significantly reduce the IADL of the old patients with MCI. Medical workers should be aware of the extent and impact of depressive symptoms in MCI and take active measures in evaluating and treating the depressive symptoms.
史亚楠, 官慧敏, 孙秋华. 老年轻度认知障碍患者抑郁情绪对工具性日常生活能力的影响[J]. 预防医学, 2018, 30(3): 221-225.
SHI Ya-nan, GUAN Hui-min, SUN Qiu-hua. Contribution of depression to instrumental ability of daily living among the elderly with mild cognitive impairment. Preventive Medicine, 2018, 30(3): 221-225.
[1] WARD A,ARRIGHI H M,MICHELS S,et al.Mild cognitive impairment:disparity of incidence and prevalence estimates[J]. Alzheimers Dement,2012,8(1):14-21. [2] WINBLAD B,PALMER K,KIVIPELTO M,et al.Mild cognitive impairment——beyond controversies,towards a consensus:report of the International Working Group on Mild Cognitive Impairment[J]. J Intern Med,2004,256(3):240-246. [3] MARSHALL G A,RENTZ D M,FREY M T,et al.Executive function and instrumental activities of daily living in mild cognitive impairment and Alzheimer's disease[J]. Alzheimers Dement,2011,7(3):300-308. [4] TRAN M,BEDARD M,DUBOIS S,et al.The influences of psychotic symptoms on the activities of daily living of individuals with Alzheimer disease:a longitudinal analysis[J]. Aging Ment Health,2013,17(6):738-747. [5] RAVAGLIA G,FORTI P,LUCICESARE A,et al.Prevalent depressive symptoms as a risk factor for conversion to mild cognitive impairment in an elderly Italian cohort[J]. Am J Geriatr Psychiatry,2008,16(10):834-843. [6] STEFFENS D C,OTEY E,ALEXOPOULOS G S,et al.Perspectives on depression,mild cognitive impairment,and cognitive decline[J]. Arch Gen Psychiatry,2006,63(2):130-138. [7] JIANG J,TANG Z,FUTATSUKA M,et al.Exploring the influence of depressive symptoms on physical disability:a cohort study of elderly in Beijing,China[J]. Qual Life Res,2004,13(7):1337-1346. [8] ROG L A,PARK L Q,HARVEY D J,et al.The independent contributions of cognitive impairment and neuropsychiatric symptoms to everyday function in older adults[J]. Clin Neuropsychol,2014,28(2):215-236. [9] ZAHODNE L B,TREMONT G.Unique effects of apathy and depression signs on cognition and function in amnestic mild cognitive impairment[J]. Int J Geriatr Psychiatry,2013,28(1):50-56. [10] WINBLAD B,PALMER K,KIVIPELTO M,et al.Mild cognitive impairment-beyond controversies,towards a consensus:report of the International Working Group on Mild Cognitive Impairment[J]. J Intern Med,2004,256(3):240-246. [11] KATZ S,AKPOM C A.12. Index of ADL[J]. Med Care,1976, 14(5 Suppl):116-118. [12] PFEFFER R I,KUROSAKI T T,HARRAH C J,et al.Measurement of functional activities in older adults in the community[J]. J Gerontol,1982,37(3):323-329. [13] 靳慧,丁斌蓉,杨霞,等. 北京版MoCA在长沙地区缺血性脑血管病人群中的应用及长沙版MoCA的形成[J]. 中国神经精神疾病杂志,2011,37(6):349-353. [14] 刘杰,王瑛,王晓慧,等. 中文版老年抑郁量表在城市社区老年人群中应用的信效度研究[J]. 中国临床心理学杂志,2013,21(01):39-41. [15] YU D S,LEE D T,WOO J.Psychometric testing of the Chinese version of the Medical Outcomes Study Social Support Survey (MOSSSS-C)[J]. Res Nurs Health,2004,27(2):135-143. [16] VICTOR W C L,LINDA C W L,HELEN F K C,et al. Validation of a Memory Inventory for the assessment of awareness of memory deficits in Alzheimer’s disease in Chinese elderly[J]. Int J Geriatr Psychiatry,2006,21:917-923. [17] 李翠萍. 泰安市农村老年人轻度认知障碍患病现况及影响因素的研究[D]. 泰山医学院,2013. [18] JIA J,ZHOU A,WEI C,et al.The prevalence of mild cognitive impairment and its etiological subtypes in elderly Chinese[J]. Alzheimers Dement,2014,10(4):439-447. [19] INZELBERG R,MASSARWA M,SCHECHTMAN E,et al.Estimating the risk for conversion from mild cognitive impairment to Alzheimer's disease in an elderly Arab community[J]. J Alzheimers Dis,2015,45(3):865-871. [20] HIDAKA S,IKEJIMA C,KODAMA C,et al.Prevalence of depression and depressive symptoms among older Japanese people:comorbidity of mild cognitive impairment and depression[J]. Int J Geriatr Psychiatry,2012,27(3):271-279. [21] JOHNSON L A,MAUER C,JAHN D,et al.Cognitive differences among depressed and non-depressed MCI participants:a project FRONTIER study[J]. Int J Geriatr Psychiatry,2013,28(4):377-382. [22] 王芬芬,唐丽,蒋天武,等. 社区三级管理模式干预老年轻度认知障碍的效果评价[J]. 浙江预防医学,2013,25(5):5-8. [23] TRAN M,BEDARD M,DUBOIS S,et al.The influences of psychotic symptoms on the activities of daily living of individuals with Alzheimer disease:a longitudinal analysis[J]. Aging Ment Health,2013,17(6):738-747. [24] COVINSKY K E,YAFFE K,LINDQUIST K,et al.Depressive symptoms in middle age and the development of later-life functional limitations:the long-term effect of depressive symptoms[J]. J Am Geriatr Soc,2010,58(3):551-556. [25] 何晓燕,曹日芳,赵国秋,等. 杭州市社区老年人认知功能状况及其影响因素[J]. 浙江预防医学,2013,25(4):8-10, 13.
