Epidemiological characteristics of pertussis among individuals aged 18 years and below in Zhejiang Province from 2016 to 2023
WANG Linxi1, ZHU Yao2, WU Beibei2, HE Hanqing2
1. School of Public Health, Hangzhou Medical College, Hangzhou, Zhejiang 310053, China; 2. Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou, Zhejiang 310051, China
Abstract：Objective To analyze the epidemiological characteristics of pertussis among the population aged ≤18 years in Zhejiang Province from 2016 to 2023, so as to provide a basis for optimizing pertussis prevention and control measures as well as immunization strategies. Methods Data on pertussis cases among individuals aged ≤18 years in Zhejiang Province from 2016 to 2023 were collected through the Infectious Disease Reporting Information System of Chinese Disease Prevention and Control Information System. Vaccination records were obtained from the specialized pertussis epidemiological survey conducted in Zhejiang Province. The descriptive epidemiological method was employed to analyze the epidemiological characteristics of pertussis among the population aged ≤18 years, as well as the interval between disease onset and the last immunization among breakthrough cases. Results A total of 7 431 pertussis cases aged ≤18 years were reported in Zhejiang Province from 2016 to 2023, with an average annual reported incidence of 8.68/105. The overall trend showed no statistical significance (P>0.05). The reported incidence remained relatively low from 2016 to 2021, consistently below 10.00/105. In contrast, the incidence rose to 33.98/105 in 2022 and 13.39/105 in 2023. The peak incidence period was from April to August, during which 4 024 cases were reported, accounting for 54.15%. Hangzhou City, Wenzhou City, and Ningbo City reported the highest number of cases, with 3 844, 1 581, and 646 cases, representing 51.73%, 21.28%, and 8.69%, respectively. In terms of average annual incidence, Hangzhou City, Wenzhou City, and Huzhou City ranked the highest, with rates of 33.98/105, 12.38/105, and 12.27/105, respectively. Among age groups, the highest reported incidence was observed in children aged 0-<1 years, at 48.87/105. From 2016 to 2023, the incidence in the 5-<10 years and 10-18 years age groups showed upward trends (AAPC=108.193%, 106.709%, both P<0.05). The proportion of cases in the 5-<10 years age group also increased during this period (P<0.05). A total of 109 breakthrough pertussis cases were identified. The median interval between disease onset and the last immunization was 4.00 (interquartile range, 4.00) years. The numbers of cases with intervals of 1-<2 years and ≥6 years were both relatively high, comprising 25 cases and 37 cases, which accounted for 22.94% and 33.94%, respectively. Conclusions From 2016 to 2021, the reported incidence of pertussis in Zhejiang Province remained relatively stable. However, a sharp increase was observed in 2022. The disease peaked during spring and summer. Key populations for targeted prevention and control included children aged 0-<1 year, 5-<10 years, and 10-18 years. The interval between disease onset and the last immunization among breakthrough pertussis cases exhibited a bimodal distribution.
王琳茜, 朱瑶, 吴蓓蓓, 何寒青. 2016—2023年浙江省18岁及以下人群百日咳流行特征分析[J]. 预防医学, 2026, 38(2): 135-139.
WANG Linxi, ZHU Yao, WU Beibei, HE Hanqing. Epidemiological characteristics of pertussis among individuals aged 18 years and below in Zhejiang Province from 2016 to 2023. Preventive Medicine, 2026, 38(2): 135-139.
[1] 中华预防医学会,中华预防医学会疫苗与免疫分会.中国百日咳行动计划专家共识[J].中国疫苗和免疫,2021,27(3):317-327. [2] MEI Z,DENIS M.As pertussis returns to pre-COVID19 endemicity,vaccination remains our best ally against an evolving Bordetella pertussis[J/OL].Emerg Microbes Infect,2025,14(1)[2026-01-25].http://doi.org/10.1080/22221751.2025.2466691. [3] STEVANOVIĆ V,ĐAKOVIĆ RODE O,TEŠOVIĆ G.Antibody response to pertussis vaccine among children and adolescents in croatia:a cross-sectional prevalence study[J/OL].Vaccines(Basel),2025,13(3)[2026-01-25].http://doi.org/10.3390/vaccines13030288. [4] 邬辉,郭世成,刘杰,等.2020—2023年江西省百日咳流行特征及免疫效果分析[J].中华流行病学杂志,2025,46(6):973-978. [5] 王雨润,李锋,许海燕,等.含百日咳成分疫苗对适龄接种儿童百日咳保护效果的配对病例对照研究[J].现代疾病预防控制,2025,36(4):265-268,274. [6] OHFUJI S,OKADA K,MOURI Y,et al.Effectiveness of four doses of pertussis vaccine during infancy diminished in elementary school age:a test-negative case-control study in Japan[J].Vaccine,2021,39(1):11-17. [7] CHRISTIE C D C.Resurgence of pertussis:whopping the‘100-day cough’[J].Curr Opin Pediatr,2025,37(5):508-516. [8] New South Wales Ministry of Health.Whooping cough:information for childcare and schools[EB/OL].[2026-01-25].https://www.health.nsw.gov.au/Infectious/whoopingcough/Pages/Information-for-childcare-and-schools.aspx. [9] YADANA S,COLEMAN K K,NGUYEN T T,et al.Monitoring for airborne respiratory viruses in a general pediatric ward in Singapore[J/OL].J Public Health Res,2019,8(3)[2026-01-25].http://doi.org/10.4081/jphr.2019.1407. [10] 黄海涛,高志刚,丁亚兴,等.天津市百日咳监测体系介绍及其运行效果的评估[J].中国当代儿科杂志,2019,21(3):218-222. [11] 李睿,亓云鹏,王远航,等.2004—2023年嘉兴市百日咳流行特征[J].预防医学,2025,37(2):139-142. [12] WANG S J,ZHANG S M,LIU J.Resurgence of pertussis:epidemiological trends,contributing factors,challenges,and recommendations for vaccination and surveillance[J/OL].Hum Vaccin Immunother,2025,21(1)[2026-01-25].http://doi.org/10.1080/21645515.2025.2513729. [13] PRINCIPI N,BIANCHINI S,ESPOSITO S.Pertussis epidemiology in children:the role of maternal immunization[J/OL].Vaccines,2024,12(9)[2026-01-25].http://doi.org/10.3390/vaccines12091030. [14] 程家国,张露平,张静,等.儿童百日咳流行现况、诊断与治疗和防控研究进展[J].医学动物防制,2026,42(2):189-194,199. [15] PITISUTTITHUM P,DHITAVAT J,SIRIVICHAYAKUL C,et al.Antibody persistence 2 and 3 years after booster vaccination of adolescents with recombinant acellular pertussis monovalent aPgen or combined TdaPgen vaccines[J/OL].EClinicalMedicine,2021,37[2026-01-25].http://doi.org/10.1016/j.eclinm.2021.100976. [16] 贾孝提,刚孩,赵桂让.2019—2021年河南省漯河市无细胞百白破疫苗疑似预防接种异常反应监测[J].河南预防医学杂志,2023,34(1):77-80. [17] 张俊杰,罗超,姜立坤,等.2015—2024年哈尔滨市百日咳流行特征分析[J].预防医学,2025,37(9):941-944.
