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预防医学  2016, Vol. 28 Issue (6): 591-593,597    
  综述 本期目录 | 过刊浏览 | 高级检索 |
代谢组学在砷中毒研究的进展和趋势
张海洋1, 管小菊1, 毛广运1, 2,郭小娟1, 2
1. 温州医科大学,浙江 温州 325035;
2. 内蒙古医科大学
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摘要 慢性砷中毒是一种地球化学性疾病,可能导致皮肤损伤、心血管疾病、免疫损伤、糖尿病和癌症等,但砷的毒作用机制目前尚不清楚。代谢组学是系统生物学的组成部分,旨在对生物体内所有代谢物(多数是相对分子质量≤1 000的小分子物质)进行定性和定量分析,了解内外因作用下生物体内源性物质变化及规律。代谢组学从微观角度研究生物代谢和表型以及生物功能变化间关系,对研究生理状态、发现生物标志物和诊断疾病具有重要作用。本文就应用代谢组学技术研究砷暴露对柠檬酸和胆碱循环及氨基酸和脂肪酸代谢的影响予以综述。
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张海洋
管小菊
毛广运
郭小娟
关键词 砷暴露代谢组学砷中毒    
收稿日期: 2015-07-17      修回日期: 2015-08-20      出版日期: 2016-06-10
中图分类号:  R599  
基金资助:国家自然科学基金(81260413); 浙江省科技厅社会公益项目(2013C33169); 浙江省自然科学基金(Y2110454)
通信作者: 郭小娟,E-mail:gxj@wzmc.edu.cn   
作者简介: 张海洋,硕士在读
引用本文:   
张海洋, 管小菊, 毛广运, 郭小娟. 代谢组学在砷中毒研究的进展和趋势[J]. 预防医学, 2016, 28(6): 591-593,597.
链接本文:  
http://www.zjyfyxzz.com/CN/Y2016/V28/I6/591
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