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预防医学  2017, Vol. 29 Issue (12): 1199-1202    DOI: 10.19485/j.cnki.issn1007-0931.2017.12.003
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浙江省实施脊髓灰质炎疫苗免疫新策略的卫生经济学评价
唐学雯,周洋,邓璇,严睿,谢淑云,何寒青
浙江省疾病预防控制中心,浙江 杭州 310051
Economic evaluation on new strategy for preventing poliomyelitis in Zhejiang Province
TANG Xue-wen,ZHOU Yang,DENG Xuan,YAN Rui,XIE Shu-yun,HE Han-qing
Zhejiang Provincial Center for Disease Control and Prevention,Hangzhou,Zhejiang,310051,China
全文: PDF(501 KB)  
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摘要 目的 评价浙江省2016年实施脊髓灰质炎(脊灰)疫苗免疫新策略后的成本效益。方法 以浙江省2016年人口为基数,以不接种策略为参照,采用成本效果比(CER)、效益成本比(BCR)和净收益(NB)等指标比较脊灰疫苗免疫新策略和原策略的成本效益,并通过调整疾病成本、疫苗价格、贴现率和接种成本进行敏感性分析。结果 脊灰疫苗免疫新策略的CER发病为1:5.27(例/万元),CER死亡为1:181.37(例/万元),BCR为12.26,NB为79 666.22万元;原策略的CER发病为1:3.29(例/万元),CER死亡为1:113.39(例/万元),BCR为19.58,NB为82 317.53万元。敏感性分析结果显示,原策略和新策略的卫生经济学评价效果一致,BCR变化幅度≤25%;疾病负担变化引起的BCR变化最大,疾病负担(80%~120%)调整后,原策略BCR变化在15.66~23.50之间,新策略BCR变化在9.81~14.71之间。结论 实施脊灰疫苗免疫新策略是现阶段全球消灭脊灰的客观要求,新策略的成本效益略低于原策略,但仍具有较好的卫生经济学意义。
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唐学雯
周洋
邓璇
严睿
谢淑云
何寒青
关键词 脊髓灰质炎免疫策略卫生经济学评价    
AbstractObjective To evaluate the economic effect of new strategy for preventing poliomyelitis in Zhejiang Province. Methods Based on the population of Zhejiang Province in 2016,cost-effectiveness ratio(CER),benefit-cost ratio(BCR),and net benefit(NB)were applied to calculate the health economic difference for the new strategy and the original strategy as compared to no vaccination strategy. Univariate sensitivity analysis was used to assess the robustness of results with main parameters; including burdens of poliomyelitis,cost of vaccines,and the vaccination program itself,and the discount rate. Results CERdisease,CERdeath,BCR and NB for the new strategy were 1:52700 RMB Yuan per case,1:1813700 RMB Yuan per case,12.26 and 796.6622 million and CERdisease,CERdeath,BCR and NB for the original strategy were 1:32900 RMB Yuan per case,1:1133900 RMB Yuan per case,19.58 and 823.1753 million,respectively. The results of the univariate sensitivity analysis with main parameters were robust. Conclusion The new strategy for preventing poliomyelitis is necessary for this period of the global polio eradication. Though the new strategy appears not as good as the original strategy on economic evaluation,its health economic benefit is significant.
Key wordsPoliomyelitis    Vaccination program    Health economic
     出版日期: 2017-12-07
ZTFLH:  R186  
基金资助:浙江省医药卫生一般研究计划(2016KYB061);浙江省预防医学会软课题(2016YF02)
通信作者: 何寒青,E-mail:hanqinghe@cdc.zj.cn   
作者简介: 唐学雯,本科,主管医师,主要从事免疫针对疾病监测工作
引用本文:   
唐学雯,周洋,邓璇,严睿,谢淑云,何寒青. 浙江省实施脊髓灰质炎疫苗免疫新策略的卫生经济学评价[J]. 预防医学, 2017, 29(12): 1199-1202.
TANG Xue-wen,ZHOU Yang,DENG Xuan,YAN Rui,XIE Shu-yun,HE Han-qing. Economic evaluation on new strategy for preventing poliomyelitis in Zhejiang Province. Preventive Medicine, 2017, 29(12): 1199-1202.
链接本文:  
http://www.zjyfyxzz.com/CN/10.19485/j.cnki.issn1007-0931.2017.12.003      或      http://www.zjyfyxzz.com/CN/Y2017/V29/I12/1199
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