Abstract：Objective To evaluate the economic effect of new strategy for preventing poliomyelitis in Zhejiang Province. Methods Based on the population of Zhejiang Province in 2016,cost-effectiveness ratio（CER）,benefit-cost ratio（BCR）,and net benefit（NB）were applied to calculate the health economic difference for the new strategy and the original strategy as compared to no vaccination strategy. Univariate sensitivity analysis was used to assess the robustness of results with main parameters; including burdens of poliomyelitis,cost of vaccines,and the vaccination program itself,and the discount rate. Results CERdisease,CERdeath,BCR and NB for the new strategy were 1:52700 RMB Yuan per case,1:1813700 RMB Yuan per case,12.26 and 796.6622 million and CERdisease,CERdeath,BCR and NB for the original strategy were 1:32900 RMB Yuan per case,1:1133900 RMB Yuan per case,19.58 and 823.1753 million,respectively. The results of the univariate sensitivity analysis with main parameters were robust. Conclusion The new strategy for preventing poliomyelitis is necessary for this period of the global polio eradication. Though the new strategy appears not as good as the original strategy on economic evaluation,its health economic benefit is significant.
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