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预防医学  2017, Vol. 29 Issue (3): 277-279    DOI: 10.19485/j.cnki.issn1007-0931.2017.03.017
  疾病预防与控制 本期目录 | 过刊浏览 | 高级检索 |
羟乙基淀粉溶液对休克患者渗透压及凝血功能的影响
杨茂宪,施云超,朱建刚,沈鹏
嘉兴市第一医院,浙江嘉兴 314001
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摘要 目的 研究羟乙基淀粉200/0.5氯化钠注射液(HS-HES)用于液体复苏,对非脓毒症休克患者血浆渗透压及凝血功能的影响。方法 选取入住某医院重症监护室的非脓毒症性休克患者42例,并随机均分为生理盐水(NS)组和HS-HES组,分别采用NS 20 mL/kg、HS-HES 10 mL/kg作液体复苏治疗,分析两组在输注前和输注后1 h、2 h的血浆渗透压、国际标准化比值(INR)、活化部分凝血活酶时间(APTT)的变化。结果 NS组输注前、输注后1 h和2 h均未见对血浆渗透压、INR及APTT有影响(均P>0.05)。HS-HES组输注前、输注后1 h和2 h的血浆渗透压分别为(282±29)mmol/L,(299±19)mmol/L和(290±25)mmol/L;INR分别为1.23±0.12,1.40±0.11和1.32±0.15;APTT分别为(41±9)s,(51±10)s和(46±11)s,输注前后比较,其中输注后1 h的血浆渗透压有升高,INR有增加,APTT有延长(均P<0.05)。HS-HES组在输注后1 h的血浆渗透压、INR、APTT均大于NS组(P<0.05)。结论 输注HS-HES能够增加血浆渗透压,同时也会影响患者内外源性凝血系统。
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杨茂宪
施云超
朱建刚
沈鹏
关键词 羟乙基淀粉200/0.5氯化钠注射液血浆渗透压国际标准化比值活化部分凝血活酶时间    
          出版日期: 2017-03-15
中图分类号:  R541.6  
基金资助:浙江省预防医学会医防整合专项科研项目(2015ZJYF -A017);嘉兴市医学重点学科(支撑学科)资助项目(04-Z-08)
作者简介: 杨茂宪,硕士,主治医师,主要从事多脏器功能衰竭保护研究工作
通信作者: 沈鹏,E-mail:docshen@126.com   
引用本文:   
杨茂宪, 施云超, 朱建刚, 沈鹏. 羟乙基淀粉溶液对休克患者渗透压及凝血功能的影响[J]. 预防医学, 2017, 29(3): 277-279.
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http://www.zjyfyxzz.com/CN/Y2017/V29/I3/277
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