Construction of a model for early identification of spotted fever and severe fever with thrombocytopenia syndrome
YANG Hui1,2, SUN Jie2, XU Pengpeng2, ZHANG Xiaqing1, HU Jieying2, LÜ Yong1,2
1. Department of Health Inspection and Quarantine, School of Public Health, Anhui Medical University, Hefei, Anhui 230032, China; 2. Lu'an Center for Disease Control and Prevention, Lu'an, Anhui 237001, China
Abstract：Objective To construct a model for clinical identification of spotted fever (SF) and severe fever with thrombocytopenia syndrome (SFTS), so as to provide insights into early identification of SF and SFTS. Methods The clinical data of laboratory-confirmed SF and SFTS patients in secondary and tertiary hospitals in Lu'an City, Anhui Province from May 2017 to May 2021 were retrieved from Chinese Disease Prevention and Control Information System. Factors affecting SF were identified using a logistic regression model, and the model for early identification of SF and SFTS was created. The model fitting effect was evaluated using Hosmer-Lemeshow test, and the value of the model for identification of SF and SFTS was evaluated using the area under the receiver operating characteristic curve (AUC). Results Data of 62 SF cases and 115 SFTS cases were included. Multivariable logistic regression analysis showed that rash (β=5.994), C-reactive protein (β=4.409), white blood cell (β=-3.176) and platelet (β=-3.234) were included in the model, which were scored 6, 4, -3 and -3, with a total score ranging from -5 to 10. Hosmer-Lemeshow test revealed a high model fitting effect (χ2=3.245, P=0.662). The AUC of the model was 0.992, and the sensitivity and specificity were 0.935 and 0.991 if the cutoff was 1. Conclusion A model for early identification of SF and SFTS that includes four variables of rash, C-reactive protein, white blood cell and platelet has been created, which has a high accuracy.
杨慧, 孙婕, 徐鹏鹏, 张夏晴, 胡颉颖, 吕勇. 斑点热与发热伴血小板减少综合征早期鉴别模型研究[J]. 预防医学, 2023, 35(2): 112-115,120.
YANG Hui, SUN Jie, XU Pengpeng, ZHANG Xiaqing, HU Jieying, LÜ Yong. Construction of a model for early identification of spotted fever and severe fever with thrombocytopenia syndrome. Preventive Medicine, 2023, 35(2): 112-115,120.
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