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预防医学  2021, Vol. 33 Issue (12): 1231-1235    DOI: 10.19485/j.cnki.issn2096-5087.2021.12.009
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低碳水化合物饮食控制超重肥胖的研究进展
陆彦妤, 郭惠兰, 沈放, 黄晓旭 综述, 张片红 审校
浙江大学医学院附属第二医院营养科,浙江 杭州 310009
Research progress on low carbohydrate diet in the control of overweight and obesity
LU Yanyu, GUO Huilan, SHEN Fang, HUANG Xiaoxu, ZHANG Pianhong
Department of Clinical Nutrition, the Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang 310009, China
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摘要 超重肥胖是慢性代谢性疾病的主要危险因素,与过早死亡风险增加密切相关。低碳水化合物饮食(LCD)经干预研究证实可在短期内(≤6个月)有效控制超重肥胖患者的体重和体脂肪,涉及的机制包括调节能量代谢、抗炎、抗氧化、改变脂质代谢相关基因表达及调节肠道菌群等。但是对于LCD能否持续减轻体重和降低超重肥胖风险,目前的研究结论并不一致。本文总结LCD控制超重肥胖的作用机制、流行病学研究、干预研究及潜在风险研究的进展,为后续研究与临床应用提供参考。
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陆彦妤
郭惠兰
沈放
黄晓旭
张片红
关键词 低碳水化合物饮食超重肥胖代谢    
Abstract:Overweight and obesity are main risk factors for chronic metabolic diseases, and are strongly associated with the increased risk of premature death. Low carbohydrate diet (LCD) has been proven to effectively control body weight and fat mass in overweight and obese patients by short-term (≤6 months) dietary intervention studies. The mechanisms include regulation of energy metabolism, anti-inflammatory, antioxidant, alteration in expression of lipid metabolic-related genes and modulation of intestinal flora. However, the conclusions are inconsistent on whether LCD can cause durable weight loss and reduce the risk of overweight and obesity. This review summarizes the current research progress on the mechanisms, epidemiological studies, intervention studies and potential risks of LCD in controlling overweight and obesity, providing a reference for the future research and clinical application.
Key wordslow carbohydrate diet    overweight    obesity    metabolism
收稿日期: 2021-06-15      出版日期: 2021-12-03
ZTFLH:  R459.3  
通信作者: 张片红,E-mail:zrlcyyzx@zju.edu.cn   
作者简介: 陆彦妤,硕士,营养师,主要从事临床营养工作
引用本文:   
陆彦妤, 郭惠兰, 沈放, 黄晓旭, 张片红. 低碳水化合物饮食控制超重肥胖的研究进展[J]. 预防医学, 2021, 33(12): 1231-1235.
LU Yanyu, GUO Huilan, SHEN Fang, HUANG Xiaoxu, ZHANG Pianhong. Research progress on low carbohydrate diet in the control of overweight and obesity. Preventive Medicine, 2021, 33(12): 1231-1235.
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