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预防医学  2018, Vol. 30 Issue (6): 578-580    DOI: 10.19485/j.cnki.issn2096-5087.2018.06.009
  论著 本期目录 | 过刊浏览 | 高级检索 |
胱抑素C、血浆致动脉硬化指数与高血压的相关性研究
俎德玲1,诸葛毅2,汪新华3,蒋一鸣1
1. 衢州市人民医院心内科,浙江 衢州 324000;
2. 衢州职业技术学院;
3. 开化县音坑乡卫生院
Correlation between cystatin C and atherogenic index of plasma change in hypertensive patients
ZU De-ling,ZHUGE Yi,WANG Xin-hua,JIANG Yi-ming
*Cardiology Department,Quzhou People's Hospital,Quzhou,Zhejiang 324000,China
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摘要 目的 了解胱抑素C(Cys C)、血浆致动脉硬化指数(AIP)与高血压的相关性及临床意义。方法 纳入2014—2015年在衢州市中心医院诊断为原发性高血压的526例患者为高血压组,同期在该院健康体检的血压正常者546人为血压正常组,进行体格检查、血生化指标和Cys C检测,分析Cys C、AIP与各项体检及生化指标的相关性。结果 高血压组和血压正常组的血清Cys C水平分别为(1.12±0.44)和(0.81±0.22)mg/L,AIP水平分别为0.68±0.03和-0.22±0.02,两组Cys C、AIP水平差异均有统计学意义(P<0.01)。血清Cys C升高,患高血压的风险随之升高(OR = 20. 06,95% CI:12.67 ~ 31.76)。高血压组的AIP分别与收缩压、体质指数、总胆固醇、三酰甘油、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇、尿酸水平均存在相关性;Cys C除上述指标外,还与肌酐水平存在相关性(均P<0.05)。结论 高血压患者的Cys C、AIP水平均高于血压正常者,且这两项指标与收缩压及多项血脂指标存在相关性,可用于临床监测高血压患者的动脉硬化和靶器官损害程度。
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俎德玲
诸葛毅
汪新华
蒋一鸣
关键词 高血压胱抑素C血浆致动脉硬化指数动脉硬化靶器官损害    
AbstractObjective To understand the correlation and clinical significance between cystatin C and atherogenic index of plasma change in hypertensive patients. Methods At the Quzhou City central hospital between 2014 and 2015,526 cases of hypertensive patients as hypertensive group and 546 cases of people with normal blood pressure in the healthy check-up as normal blood pressure group were investigated with physical examination,blood biochemical index detection and the serum cystatin C level detection. The analysis of the relationship between the serum cystatin C level and atherogenic index of plasma among two groups was done. Results The evidence that the serum cystatin C level between hypertensive group and normal blood pressure group shows respectively as:1.12±0.44(mg/L)and 0.81±0.22(mg/L),atherogenic index of plasma shows respectively as:0.68±0.03 and -0.22±0.02,both differences were statistically significant(P<0.01). As the serum cystatin C level increased,the risk of hypertension increased(OR=20.06,95%CI:12.67-31.76). Plasma arteriosclerosis index in hypertensive group was correlated with systolic blood pressure,body mass index,total cholesterol,triglyceride,high-density lipoprotein,LDL cholesterol,and uric acid level respectively,all differences were statistically significant. In addition to the above indicators,the serum cystatin C level in hypertensive group was correlated with serum creatinine level (all P<0.05). Conclusion The serum cystatin C level and plasma arteriosclerosis index in patients with hypertension both were higher than those with normal blood pressure. These two indicators were correlated with systolic blood pressure and multiple blood lipid indicators. They could be used to monitor arteriosclerosis and target organ damage in patients with hypertension.
Key wordsHypertension    Cystatin C    Atherogenic index of plasma    Atherosclerosis    Target organ damage
     出版日期: 2018-06-04
ZTFLH:  R544.1  
基金资助:衢州市科技计划资助项目(2014J023)
通信作者: 诸葛毅,E-mail:zhugeyi@126.com   
作者简介: 俎德玲,本科,主任医师,主要从事临床心脑血管病防治工作
引用本文:   
俎德玲,诸葛毅,汪新华,蒋一鸣. 胱抑素C、血浆致动脉硬化指数与高血压的相关性研究[J]. 预防医学, 2018, 30(6): 578-580.
ZU De-ling,ZHUGE Yi,WANG Xin-hua,JIANG Yi-ming. Correlation between cystatin C and atherogenic index of plasma change in hypertensive patients. Preventive Medicine, 2018, 30(6): 578-580.
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http://www.zjyfyxzz.com/CN/10.19485/j.cnki.issn2096-5087.2018.06.009      或      http://www.zjyfyxzz.com/CN/Y2018/V30/I6/578
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