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| Characteristics of pathogens among severe acute respiratory infection cases in Tianjin Municipality |
| LIU Xiaochang1, GUO Liru1, YANG Jie1, WU Mingkun1, KONG Mei1, ZHANG Peng1, LI Xiaoyan1,2
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1. Tianjin Center for Disease Control and Prevention, Tianjin 300011, China;
2. School of Public Health, Tianjin Medical University, Tianjin 300070, China |
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Abstract Objective To analyze the infection characteristics of pathogens among cases with severe acute respiratory infection (SARI) in Tianjin Municipality, so as to provide the evidence for developing regional SARI prevention and control strategies. Methods Sputum or throat swab specimens were collected from SARI cases at six sentinel hospitals for respiratory pathogen surveillance in Tianjin Municipality from January 2024 to December 2025. A multiplex real-time PCR nucleic acid detection kit for respiratory pathogens was used to detect 14 types of SARI pathogens. Descriptive analysis was conducted to explore pathogen detection status, as well as temporal and age distribution characteristics. Results A total of 3 402 specimens were collected, with 1 456 pathogen-positive samples and positive detection rate of 42.80%. More positive samples were detected from October to December, with 205, 232 and 274 positive samples accounting for 38.90%, 44.87% and 51.02%, respectively. Mycoplasma pneumoniae, Haemophilus influenzae and Streptococcus pneumoniae had relatively high positive detection rates of 10.58%, 9.88% and 6.61%, respectively. The top three pathogens ranked by positive detection rate for single infection were Mycoplasma pneumoniae, influenza A virus and Haemophilus influenzae, while the top four pathogen combinations ranked by positive detection rate for mixed infection were Haemophilus influenzae combined with Mycoplasma pneumoniae, Haemophilus influenzae combined with Streptococcus pneumoniae, respiratory syncytial virus combined with Streptococcus pneumoniae, and Haemophilus influenzae combined with influenza A virus. The 0-<6 years and 6-<18 years age groups exhibited relatively high pathogen positive detection rates of 61.14% and 59.97%, respectively. Conclusions The predominant pathogens among SARI patients in Tianjin Municipality were Mycoplasma pneumoniae, Haemophilus influenzae and Streptococcus pneumoniae. The risk of pathogen infection was higher in autumn and winter and among population aged 0-<18 years.
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Received: 27 February 2026
Revised: 26 May 2026
Published: 27 July 2026
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