Abstract：Objective To analyze the characteristics of adverse reactions for varicella attenuated live vaccine（VarV）in Henan Province from 2011 to 2016，in order to evaluate the immunization safety related to VarV. Methods The adverse reaction data and vaccination doses of VarV in Henan Province from 2011 to 2016 were collected through the China Information Management System for Immunization Programming. The descriptive methodology was used for data analysis. Results A total of 686 adverse reactions cases were reported in Henan Province from 2011 to 2016，and the average reported incidence rate was 16.89 per 100 000 dose. The ratio of male to female was 1.14∶1，and 80.61% cases occurred between 1 and 2 years old，and the reported incidence rate was 13.62 per 100 000 dose. And 32.80% cases were reported from April to June，and the reported incidence rate was 5.54 per 100 000 dose. The cases were mainly concentrated in Zhengzhou，Luoyang，Zhoukou and Xinyang. Most cases occurred after the first dose and within 1 d after vaccination. The main diagnoses of adverse reactions were fever，local swelling，indurations and transient anaphylactic disorders. The reported incidence rate of anaphylactic shock and fever convulsion were 0.37 per 100 000 dose and 0.12 per 100 000 dose respectively. All cases were recovered or got better. Conclusion The safety of VarV was good in Henan Province. However， the surveillance should focus on the anaphylactic shock and fever convulsion and other serious rare adverse reaction.
史鲁斌, 杨建辉, 姬艳芳, 李军, 于燕, 叶莹, 张延炀. 水痘减毒活疫苗接种不良反应监测结果分析[J]. 预防医学, 2017, 29(10): 1009-1012,1016.
SHI Lu-bin, YANG Jian-hui, JI Yan-fang, LI Jun, YU Yan, YE Ying, ZHANG Yan-yang. An analysis on the surveillance results of safety of post-marketing immunization of varicella attenuated live vaccine in Henan Province. Preventive Medicine, 2017, 29(10): 1009-1012,1016.
World Health Organization. Varicella vaccines:WHO position paper，August 1998 [EB/OL] .[2017-02-28] . http://apps.who.int/iris/bitstream/10665/230537/1/WER7332_241-248.PDF.
GALEA S A，SWEET A，BENINGER P，et al. The safety profile of varicella vaccine:a 10-year review[J] . J Infect Dis，2008，197（2）:165-169.
[17]
MAGLIONE M A，DAS L，RAAEN L，et al. Safety of vaccines used for routin immunization of US children:a systematic review[J] . Pediatrics，2014，134（ 2）:325-337.
