Please wait a minute...
文章检索
预防医学  2017, Vol. 29 Issue (8): 786-789    DOI: 10.19485/j.cnki.issn1007-0931.2017.08.007
  论著 本期目录 | 过刊浏览 | 高级检索 |
肾功能轻度下降与代谢综合征及其组分的关系
周攀1, 蒋丹1, 郑睿智2, 朱益民2
1.舟山市普陀人民医院,浙江 舟山 316000;
2. 浙江大学医学院
A study on the associations between reduced kidney function and metabolic syndrome and its components
ZHOU Pan, JIANG Dan, ZHENG Rui-zhi, ZHU Yi-min
Putuo People' Hospital of Zhoushan City,Zhoushan,Zhejiang,316000,China
全文: PDF(581 KB)  
输出: BibTeX | EndNote (RIS)      
摘要 目的 探讨肾功能轻度下降与代谢综合征(MS)及其组分的关联。方法 对2009年中国健康与营养调查数据库中7 309名研究对象资料进行分析,MS诊断采用中华医学会糖尿病分会制定的标准,肾脏损伤程度采用MDRD公式估算的肾小球滤过率(eGFR)作为判定指标,比较eGFR轻度下降与正常组各指标差异,分析肾功能轻度损伤与MS的关系。结果 共诊断出MS患者2 034例,患病率为27.83%。MS患者中eGFR轻度下降1 508例(74.14%),非MS患者eGFR轻度下降3 357例(63.64%),MS患者eGFR轻度下降比例高于非MS患者(P<0.05),且eGFR轻度下降比例随代谢异常组分的增加呈上升趋势(P<0.05)。Logistics回归分析结果显示,高空腹血糖(OR=1.22,95%CI: 1.06~1.42)、高三酰甘油(OR=1.21,95%CI: 1.05~1.38)和低高密度脂蛋白胆固醇(OR=1.23,95%CI: 1.06~1.41)是eGFR轻度下降的危险因素。结论 MS及其组分高空腹血糖、高三酰甘油和低高密度脂蛋白胆固醇是发生肾功能轻度下降的危险因素,应对MS人群的肾功能进行重点筛查。
服务
把本文推荐给朋友
加入引用管理器
E-mail Alert
RSS
作者相关文章
周攀
蒋丹
郑睿智
朱益民
关键词 肾小球滤过率代谢综合征三酰甘油血糖    
AbstractObjective To explore the association between estimated glomerular filtration rate (eGFR) and metabolic syndrome (MS). Method The data were from the China Health and Nutrition Survey (CHNS). The data included the physical measurement and biochemical markers of adults of CHNS in 2009. Finally,7309 individual observations were included in the analysis. Results According to the criteria of MS,2 034 patients were diagnosed as MS,and the prevalence was 27.83%. There were 1508 (74.14%) patients had moderate reduced eGFR in MS patients,and 3357 individuals (63.64%) were diagnosed as moderate reduced eGFR in non-MS patients. There was significant difference between two groups ( χ2=72.13,P<0.001). The incident of moderate reduced eGFR was positively associated with fasting plasma glucose(OR=1.22,95%CI: 1.06-1.42,P=0.005),triglyceride(OR=1.21,95%CI: 1.05-1.38,P=0.005) and negatively associated with HDL-C(OR=1.23,95%CI: 1.06-1.41,P=0.004). Conclusion The MS and its components might be the influencing factors of developing moderate reduced eGFR,and the screening should be focused on the population with MS.
Key wordsGlomerular filtration rate    Metabolic syndrome    Triglyceride    Fasting plasma glucose
收稿日期: 2017-03-06      修回日期: 2017-04-21      出版日期: 2017-08-10
中图分类号:  R589  
作者简介: 周攀,本科,副主任医师,主要从事肾内及风湿免疫工作
通信作者: 周攀,E-mail: zppzi1234@aliyun.com   
引用本文:   
周攀, 蒋丹, 郑睿智, 朱益民. 肾功能轻度下降与代谢综合征及其组分的关系[J]. 预防医学, 2017, 29(8): 786-789.
ZHOU Pan, JIANG Dan, ZHENG Rui-zhi, ZHU Yi-min. A study on the associations between reduced kidney function and metabolic syndrome and its components. Preventive Medicine, 2017, 29(8): 786-789.
链接本文:  
https://www.zjyfyxzz.com/CN/10.19485/j.cnki.issn1007-0931.2017.08.007      或      https://www.zjyfyxzz.com/CN/Y2017/V29/I8/786
[1] 康阳阳,刘章锁,刘东伟. 中国成人慢性肾脏病患病率荟萃分析[J]. 中国实用内科杂志,2016,36(9):785-789.
[2] 李增芳,杨芬芳,蔡菊芳,等. 杭州市5310例健康体检人群慢性肾脏病的患病情况及危险因素分析[J]. 实用预防医学,2016,23(8):969-972.
[3] 田进信,缪敏,袁静义,等. 尿酸水平与代谢综合征关系的横断面研究[J]. 浙江预防医学,2009,21(9):3-5.
[4] ZHANG B,ZHAI F Y,DU S F,et al. The China Health and Nutrition Survey,1989-2011[J]. Obes Rev,2014,15(Suppl 1): 2-7.
[5] LEVEY A S,ECKARDT K U,TSUKAMOTO Y,et al. Definition and classification of chronic kidney disease:a position statement from Kidney Disease Improving Global Outcomes(KDIGO)[J]. Kidney Int,2005,67(6):2089-2100.
[6] 胡浙芳,丁钢强,章荣华,等. 3种代谢综合征诊断标准在杭州市城区人群中应用比较[J]. 浙江预防医学,2013,25(12):12-15.
[7] 叶巧玉,项晓青,倪晓媚,等. 18岁以上人群代谢综合征流行的现状研究[J]. 浙江预防医学,2012,24(8):1-3, 12.
[8] LU J,WANG L,LI M,et al. Metabolic syndrome among adults in China:The 2010 China Noncommunicable Disease Surveillance[J]. J Clin Endocrinol Metab,2017,102(2):507-515.
[9] PRASAD G R. Metabolic syndrome and chronic kidney disease:Current status and future directions[J]. World Journal of Nephrology,2014,3(4):210.
[10] KRINSLEY J S. Glycemic variability and mortality in critically ill patients:the impact of diabetes[J]. J Diabetes Sci Technol,2009,3(6):1292-1301.
[11] HILL C J,CARDWELL C R,PATTERSON C C,et al. Chronic kidney disease and diabetes in the national health service:a cross-sectional survey of the U.K. national diabetes adult[J]. Diabet Med,2014,31(4):448-454.
[12] CONSERVA F,PONTRELLI P,ACCETTURO M,et al. The pathogenesis of diabetic nephropathy:focus on microRNAs and proteomics[J]. Nephrol,2013,26(5):811-820.
[13] 蒋阳,胡耀琪,唐娟. 慢性肾脏病患者的高血压患病情况调查[J]. 浙江预防医学,2015,27(7):703-705.
[14] KAUKINEN A,KUUSNIEMI A M,HELIN H,et al. Changes in glomerular mesangium in kidneys with congenital nephrotic syndrome of the Finnish type [J]. Pediatr Nephrol,2010,25(5):867-875.
[15] LEE H S,LEE J S,KOH H I,et al. Intra glomerular lipid deposition in routine biopsies[J]. Clin Nephrol,1991,36(2):67-75.
[1] 俞丹丹, 杨加丽, 张雅萍, 许慧琳, 何丹丹, 李俊. 2型糖尿病共病患者空腹血糖波动轨迹的影响因素研究[J]. 预防医学, 2025, 37(6): 562-567,572.
[2] 陆丽君, 袁磊, 李殿江, 卢昆, 朱怡萱, 王志勇, 刘思浚. 老年2型糖尿病患者自我效能、自我管理行为在抑郁症状与血糖控制间的中介效应分析[J]. 预防医学, 2025, 37(5): 455-459.
[3] 邓天瑞, 王志勇, 叶青, 唐伟, 杨斌, 徐斐. 老年代谢综合征患者健康相关生命质量研究[J]. 预防医学, 2025, 37(4): 325-330.
[4] 李佳文, 熊小梅, 王育珊. 身体测量指标筛查代谢综合征的效果比较[J]. 预防医学, 2025, 37(2): 163-167,172.
[5] 王慧, 高霞, 朱晓云, 马芳军. 社区2型糖尿病患者血糖控制达标的影响因素分析[J]. 预防医学, 2024, 36(5): 423-427.
[6] 喜小梅, 吕雅莉, 刘永斌, 祁生顺, 吴建军, 魏兴民. 石化企业职工代谢综合征调查[J]. 预防医学, 2024, 36(5): 432-436.
[7] 修雪燕, 迪娜·木合亚提, 赵玉洁, 韩加. 全麦粉对高脂喂养小鼠糖脂水平和抗氧化能力的影响[J]. 预防医学, 2024, 36(4): 365-368.
[8] 王盼, 张晓晗, 黄涛. 成年人收缩压与尿酸、血脂、血糖的关联研究[J]. 预防医学, 2023, 35(9): 746-751.
[9] 倪蕾, 殷文军, 刘艳茹, 李群燕, 易桂林, 陈振龙. 职业性噪声暴露和动脉硬化对血糖水平的交互影响研究[J]. 预防医学, 2023, 35(2): 108-111.
[10] 高慧, 朱旭婷, 张磊, 姜玉, 夏庆华, 张云. 糖尿病前期与肿瘤发病风险研究[J]. 预防医学, 2023, 35(11): 931-934.
[11] 王倩倩, 曲淑娜, 于绍轶, 张红杰. 脂质蓄积指数和内脏脂肪指数筛查中老年人群代谢综合征研究[J]. 预防医学, 2022, 34(9): 928-931.
[12] 陶寄, 盛敏阳, 许云峰, 孙品晶, 钟节鸣, 王小花. 海宁市居民血脂异常的影响因素分析[J]. 预防医学, 2022, 34(8): 821-825.
[13] 汤洋, 李琳, 廖兴, 林坚. 2型糖尿病患者体感运动联合神经肌肉穴位电刺激干预效果评价[J]. 预防医学, 2022, 34(8): 794-798.
[14] 陈素庭, 洪航, 许国章. 抗病毒治疗的HIV/AIDS病例高血糖的影响因素分析[J]. 预防医学, 2022, 34(11): 1110-1115,1120.
[15] 丁有红, 崔岚, 苏健, 陈路路, 陶然, 覃玉. 中老年人群高三酰甘油腰围表型与空腹血糖受损、糖尿病的关系研究[J]. 预防医学, 2021, 33(2): 125-129.
Viewed
Full text


Abstract

Cited

  Shared   
  Discussed